Description

Book Synopsis

The expanded guide to cardiac mapping

The effective diagnosis and treatment of heart disease may vitally depend upon accurate and detailed cardiac mapping. However, in an era of rapid technological advancement, medical professionals can encounter difficulties maintaining an up-to-date knowledge of current methods. This fifth edition of the much-admired Cardiac Mapping is, therefore, essential, offering a level of cutting-edge insight that is unmatched in its scope and depth.

Featuring contributions from a global team of electrophysiologists, the book builds upon previous editions? comprehensive explanations of the mapping, imaging, and ablation of the heart. Nearly 100 chapters provide fascinating accounts of topics ranging from the mapping of supraventricular and ventriculararrhythmias, to compelling extrapolations of how the field might develop in the years to come. In this text, readers will find:

  • Full coverage of all aspects of c

    Table of Contents

    About the Companion Website and Companion Digital Edition xii

    List of Videos xiii

    List of Contributors xvi

    Editors of Previous Editions xxxiv

    Preface to the Fifth Edition xxxv

    Preface to the First Edition xxxvi

    Foreword by Douglas P. Zipes and A. John Camm xxxvii

    Part I Fundamentals of Cardiac Mapping

    1 History of Cardiac Mapping 1
    Stephan Zellerhoff, Lars Eckardt, and Gunter Breithardt

    2 Embryology, Anatomy, and Pathology of Ventricular Outflow Tracts Related to Cardiac Mapping and Arrhythmias 7
    Bastiaan J.D. Boukens, Cristina Basso, Federico Migliore, Stefania Rizzo, and Gaetano Thiene

    3 Arrhythmogenic Venous Extremity of the Cardiac Tube 29
    Marco Galeazzi

    4 The Impact of Embryology and Anatomy on Cardiac Electrophysiology 37
    Maxim Didenko and Fred Kusumoto

    5 Cardiac Morphology Relevant to Mapping 46
    Niyada Naksuk, Vaibhav R. Vaidya, Nirusha Lachman, and Samuel J. Asirvatham

    6 Anatomy of the Outflow Tract Region: Relevance to Arrhythmias and Catheter Ablation 61
    Andres Enriquez, Jason Bradfield, Kalyanam Shivkumar, and Fermin C. Garcia

    7 Fundamentals of Cardiac Mapping 70
    Fu Siong Ng, Caroline Roney, Chris D. Cantwell, and Nicholas S. Peters

    8 Troubleshooting to Avoid Failed Ablation 84
    Krishna Kancharla, Suraj Kapa, and Samuel J. Asirvatham

    Part II Imaging Technologies in Cardiac Mapping and Ablation

    9 Intracardiac Echocardiography 95
    Pasquale Santangeli, Mathew D. Hutchinson, and David J. Callans

    10 Role of Cardiac Computed Tomography Imaging to Guide Catheter Ablation of Arrhythmias in Complex Cardiac Morphologies 104
    Farhood Saremi

    11 Role of Cardiac Magnetic Resonance Imaging and Late Gadolinium Enhancement in Relation to Arrhythmias in Different Cardiomyopathies 123
    John Duell and Timm Dickfeld

    12 Multimodal Imaging for Cardiac Mapping 136
    Donald D. Hegland, Kevin P. Jackson, and James P. Daubert

    13 Light and the Heart: Cardiac Optogenetics 152
    Naim Shaheen, Amit Gruber, and Lior Gepstein

    14 Cardiac Mapping and Imaging in Patient Selection for Cardiac Resynchronization Therapy: How to Identify Super‐responders, Responders, and Non‐responders 170
    Bettina Kirstein and Christopher Piorkowski

    Part III Advances in Technology

    15 Towards Non‐invasive Mapping and Imaging of Cardiac Arrhythmias 180
    Edgard A. Prihadi, Victoria Delgado, and Jeroen J. Bax

    16 New High‐Density and Automated Mapping Systems 197
    Albert Y. Sun, Jonathan P. Piccini, and James P. Daubert

    17 Non‐invasive Body Surface Potential Mapping of Reentrant Drivers in Human Atrial Fibrillation 211
    Ruairidh Martin, Meleze Hocini, Remi Dubois, Nicholas Derval, Pierre Jais, and Michel Haissaguerre

    18 Electrophysiology of Heart Failure: Non‐invasive Mapping of Substrate and Guidance of Cardiac Resynchronization Therapy with Electrocardiographic Imaging 220
    Yoram Rudy

    19 Contact Mapping and Ablation of Complex Cardiac Arrhythmias 236
    Sanjiv M. Narayan, Junaid A.B. Zaman, Chad Brodt, Fatemah Shenasa, Tina Baykaner, and Wouter‐Jan Rappel

    20 Advances in Atrial Fibrillation Ablation 252
    Atul Verma and Mohammad Shenasa

    21 Integration of Contact Force into Mapping and Ablation Systems: Does It Improve the Results? 289
    Waqas Ullah and Richard Schilling

    22 Advances in Molecular Imaging Relevant to Arrhythmias 300
    Arnold F. Jacobson and Jagat Narula

    Part IV Mapping in Experimental Models of Cardiac Arrhythmias

    23 Optical Mapping of Sarcoplasmic Reticulum Ca2+ and Transmembrane Potential in the Intact Heart: Insights into Ca2+‐mediated Arrhythmias 313
    Lianguo Wang and Crystal M. Ripplinger

    24 Electrophysiological Substrates for Gender Difference in the Incidence of Torsades de Pointes Arrhythmias 321
    Nabil El‐Sherif , Herman D. Himel, Yuan Yue, Mohamed Boutjdir , and Mark Restivo

    25 Rotors in Animal Models of Atrial Fibrillation 330
    Omer Berenfeld, David Filgueiras‐Rama, and Makarand Deo

    26 Atrial Fibrillation from a Unipolar, High‐resolution Perspective 343
    Natasja M.S. de Groot, Maurits A. Allessie, Lisette J.M.E. van der Does, and Ad J.J.C. Bogers

    27 Mechanisms Underlying Arrhythmogenesis in the J‐wave Syndromes 351
    Eleonora Savio‐Galimberti, Mariana Argenziano, and Charles Antzelevitch

    28 Relationship Between Cardiac Alternans, Calcium Cycling, and Ventricular Arrhythmias 364
    James N. Weiss and Zhilin Qu

    29 Fibrosis and Arrhythmogenesis 375
    Andre G. Kleber and Michiel J. Janse

    30 Triggered Ventricular Tachyarrhythmias Initiated by Enhanced Late Inward Na and Ca Currents: Novel Therapeutic Targets 383
    Hrayr S. Karagueuzian

    31 Experimental VT: A New Porcine Model of Infarct‐related Reentrant VT 398
    Elad Anter, Andrew L. Wit, and Mark E. Josephson

    32 Experimental Mapping of Ventricular Arrhythmias: Intramural Pathways and Substrate 408
    Nigel A. Lever, Ian J. LeGrice, Darren A. Hooks, Mark L. Trew , Bryan J. Caldwell, and Bruce H. Smaill

    33 The Molecular Basis of Long QT Type 2 (LQT2)‐related Arrhythmias: How Sex Modifies the Risk of Torsades de Pointes 422
    Jan Němec, Jong J. Kim, and Guy Salama

    34 Optical Mapping of Arrhythmogenic Remodeling in the Failing Human Heart 431
    Fu Siong Ng, Jaclyn A. Brennan, and Igor R. Efimov

    35 Optical Mapping of Successful and Failed Defibrillation 448
    Kedar K. Aras, Bastiaan J.D. Boukens, Crystal M. Ripplinger, Christopher R. Gloschat, and Igor R. Efimov

    36 Atrial Patterns of Neurally Induced Repolarization Changes: Neuroablative Studies in Canines 464
    Rene Cardinal and Pierre Page

    Part V Mapping and Imaging in Atrial Fibrillation, Flutter, and Atrial Tachycardias

    37 Clinical Relevance of Functional Models of Atrial Reentry and Fibrillation 473
    Stanley Nattel and Vincent Algalorrondo

    38 Rotor Mapping in Patients with Atrial Fibrillation 482
    Sanjiv M. Narayan, Tina Baykaner, Chad Brodt, Junaid A.B. Zaman, Christopher A.B. Kowalewski, David Vidmar, and Wouter‐Jan Rappel

    39 Rotor Mapping and Ablation in Persistent Atrial Fibrillation 496
    Yenn‐Jiang Lin, Men‐Tzung Lo, Li‐Wei Lo, Fa‐Po Chung, and Shih‐Ann Chen

    40 Mapping and Ablation of Atrial Flutter and its Variants 506
    Gregory K. Feld, Jonathan Hsu, Gautam Lalani, and Amir Schricker

    41 Mapping and Ablation of Left Atrial Flutter and Tachycardia: New Observations 530
    Philipp Sommer and Gerhard Hindricks

    42 Mapping and Ablation of Atrial Tachycardia 538
    Karoly Kaszala, Jayanthi Koneru, and Kenneth A. Ellenbogen

    43 Image‐based Risk Stratification for Stroke in Atrial Fibrillation 553
    Jorge Romero, David Briceno, Carola Gianni, Sanghamitra Mohanty , Andrea Natale, Mario Garcia, and Luigi Di Biase

    44 Revisiting Non‐pulmonary Vein Triggers 565
    Carola Gianni, Javier E. Sanchez, Amin Al‐Ahmad, Rodney P. Horton, Patrick M. Hranitzky, J. David Burkhardt, Sanghamitra Mohanty, Chintan Trivedi, Luigi Di Biase, and Andrea Natale

    45 Mechanisms of Antifibrillatory Agents for Atrial Fibrillation: Evidence Obtained from Experimental Models 580
    Gerrit Frommeyer and Lars Eckardt

    46 Stepwise Approach to Atrial Fibrillation Mapping and Ablation in Persistent and Long‐standing Persistent Atrial Fibrillation: Short‐ and Long‐term Results 587
    Julia Vogler, Boris A. Hoffmann, Daniel Steven, Christian Meyer, Benjamin Schaeffer, Doreen Schreiber, Arian Sultan, Thomas Rostock, and Stephan Willems

    47 Mapping and Ablation of the Cardiac Autonomic Nervous System to Treat Atrial Fibrillation 594
    Stavros Stavrakis, Paul Garabelli, Benjamin J. Scherlag, and Sunny S. Po

    48 Remodeling in Atrial Fibrillation: Novel Mapping Studies 604
    Thomas H. Everett IV and Jeffrey E. Olgin

    49 Magnetic Resonance Imaging Mapping of Atrial Fibrosis and Atrial Fibrillation 618
    Leenhapong Navaravong and Nassir F. Marrouche

    50 Fibrotic Atrial Cardiomyopathy: Implications for Ablation of Atrial Fibrillation 628
    Hans Kottkamp, Andreas Rieger, Fabian Moser, and Christian Poenisch

    51 Mapping and Ablation of the Left Atrial Appendage 635
    Anthony J. Choi and Moussa Mansour

    52 Electrogram‐based Mapping and Ablation in Atrial Fibrillation 643
    Ayman A. Hussein and Walid Saliba

    53 Phase Mapping of Human Atrial Fibrillation 652
    Mohammed Saeed, Omer Berenfeld, and Hakan Oral

    54 Trials on Atrial Fibrillation Mapping and Ablation 660
    Antonio Sorgente and Riccardo Cappato

    Part VI Mapping of Supraventricular Arrhythmias

    55 Entrainment Mapping in Supraventricular Tachycardias 665
    John M. Miller, Rahul Jain, Gopi Dandamudi, Seeongwook Han, and Thomas R. Kambur

    56 The Problematic Postpacing Interval 678
    John M. Miller, Rahul Jain, Gopi Dandamudi, Seeongwook Han, and Thomas R. Kambur

    57 Mapping and Ablation of Typical and Atypical Accessory Pathways 689
    James P. Daubert and Edward Sze

    58 Preexcited Atrioventricular Junctional Reentrant Tachycardia: Electrophysiological Characteristics of the Reentrant Circuits 717
    Mohammad‐Reza Jazayeri and Mohammad‐Ali Jazayeri

    59 Mapping and Ablation of Atrioventricular Nodal Reentry Tachycardia and its Variants: Current Understanding and Controversies 751
    Demosthenes G. Katritsis and Mark E. Josephson

    60 Electrical Stimulation Maneuvers to Differentiate Different Forms of Supraventricular Tachycardias 766
    Kevin Ng, George J. Klein, Allan C. Skanes, Lorne J. Gula, Raymond Yee, Jaimie Manlucu, and Peter Leong‐Sit

    61 Mechanisms of Persistent Atrial Fibrillation: What Do the Clinical Mapping Studies Teach Us? 780
    Tomos E. Walters, Geoffrey Lee, and Jonathan M. Kalman

    62 Imaging and Mapping of Arrhythmias in Hypertrophic Cardiomyopathy 798
    Mark S. Link, Christopher Phelan, Mohamed Aljaabari, and N. A. Mark Estes, III

    63 Mapping and Ablation of Supraventricular Arrhythmias in Congenital Heart Disease 809
    Paul Khairy

    64 Cardiac Mapping and Imaging: Arrhythmias in Patients with Congenital Heart Disease 824
    Sabine Ernst

    Part VII Mapping and Imaging of Ventricular Arrhythmias

    65 Mapping and Ablation of Ventricular Tachycardia in Normal Hearts 833
    David J. Callans, Fermin C. Garcia, and Pasquale Santangeli

    66 The Combination of a Basket Catheter and EnSite™ Mapping System Improves Catheter Ablation of Right Ventricle Outflow Premature Ventricular Contraction 843
    Takashi Tokano and Yuji Nakazato

    67 Mapping and Ablation of Ventricular Arrhythmias: Patients with Non‐Ischemic Cardiomyopathy 854
    Roy M. John and William G. Stevenson

    68 Mapping and Ablation of Ventricular Arrhythmias in Patients with Congenital Heart Disease 864
    Elizabeth DeWitt and Edward P. Walsh

    69 Substrate Ablation for Ventricular Tachycardia in Structural Heart Disease 881
    Jorge Romero, David Briceno, Carola Gianni , Sanghamitra Mohanty , J. David Burkhardt , Soo Kim, Amin Al‐Ahmad, Andrea Natale , and Luigi Di Biase

    70 Coronary Mapping and Ablation of Arrhythmias 894
    Sercan Okutucu and Ali Oto

    71 Endocardial Catheter Pace Mapping of Ventricular Tachycardias 901
    Mithilesh K. Das, John M. Miller, Deepak Bhakta, Gopi Dandamudi, and Thomas R. Kambur

    72 Resetting and Entrainment Phenomena: Application to Mapping of Ventricular Tachycardia 911
    Mark E. Josephson, Jesus Almendral, Eduardo Castellanos, Teresa Barrio‐Lopez, and Mercedes Ortiz

    73 Mapping and Ablation of Idiopathic Ventricular Fibrillation 922
    Ghassen Cheniti, Meleze Hocini, Nathaniel Thompson, Arnaud Denis, Josselin Duchateau, Ruairidh Martin, Masateru Takigawa, Antonio Frontera, Gregoire Massoullie, Konstantinos Vlachos, Takeshi Kitamura, Michael Wolf, Nicolas Derval, Frederic Sacher, Pierre Jais, Remi Dubois, and Michel Haissaguerre

    74 Mapping and Ablation in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy: Epicardial and Endocardial Mapping and Long‐Term Results 934
    Fabrizio Assis and Harikrishna Tandri

    75 Mapping and Ablation of Ventricular Arrhythmias in Patients with Cardiac Sarcoidosis 947
    Matthew M. Zipse, Wendy S. Tzou, and William H. Sauer

    76 Cardiac Mapping and Imaging in Patients with Ventricular Arrhythmias in Chagas Disease Undergoing Catheter Ablation of Ventricular Tachycardia 960
    Cristiano Faria Pisani, Mauricio Scanavacca, and Andre D’Avila

    77 Magnetic Resonance Imaging Mapping of Ventricular Tachycardia in Patients with Different Cardiomyopathies (Arrhythmogenic Right Ventricular Dysplasia, Amyloidosis, etc.) 970
    Jonathan Chrispin and Saman Nazarian

    78 Mapping and Ablation of Ventricular Arrhythmias of Unusual Sites 978
    Srikant Duggirala and Edward P. Gerstenfeld

    79 Mapping and Ablation of Ventricular Tachycardia in Coronary Artery Disease 992
    Tanyanan Tanawuttiwat and Joseph E. Marine

    80 Epicardial Mapping in Different Ventricular Tachycardia Substrates: Technique and Instrumentation, Short‐ and Long‐term Results 1007
    Henry H. Hsia and Zhenning Nie

    81 Usefulness of the 12‐Lead ECG to Identify Epicardial Ventricular Substrate and Epicardial Ventricular Tachycardia Site of Origin 1028
    Victor Bazan and Francis E. Marchlinski

    82 Mapping and Imaging of Fascicular Ventricular Tachycardia 1050
    Rakesh Latchamsetty and Frank Bogun

    83 Scar‐Related Ventricular Tachycardia Mapping and Ablation Using Contrast‐Enhanced Magnetic Resonance Imaging 1062
    Antonio Berruezo, Juan Fernandez‐Armenta, Diego Penela, Juan Acosta, Josep Brugada, Lluis Mont , and Beatriz Jauregui

    Part VIII Future Directions and Technologies in Cardiac Mapping and Imaging of Cardiac Arrhythmias

    84 Myocardial Elastography 1073
    Elisa Konofagou

    85 Electromechanical Wave Imaging 1083
    Elisa Konofagou

    86 Principles of Diffusion Tensor Imaging of the Myocardium: Clinical Applications 1096
    Mohammad Shenasa, Hossein Shenasa, and Javad Rahimian

    87 Diffusion Magnetic Resonance Imaging Tractography of the Heart 1113
    Choukri Mekkaoui and David E. Sosnovik

    88 Molecular Magnetic Resonance Imaging in Cardiac Electrophysiology 1124
    David E. Sosnovik

    89 Real‐Time MRI Mapping and Ablation 1132
    Sebastian Hilbert, Philipp Sommer, Ingo Paetsch, Cosima Jahnke, and Gerhard Hindricks

    90 Robotic Navigation for Atrial Fibrillation: Mapping and Ablation 1137
    Jonathan S. Steinberg and Robert Altman

    91 Mapping and Ablation in Patients with VT Storm: Role of Neuraxial Therapeutics 1140
    Olujimi A. Ajijola, Kalyanam Shivkumar, and Marmar Vaseghi

    92 Appropriateness of Mapping and Imaging Modalities in Interventional Electrophysiology 1152
    Emily P. Zeitler and Sana M. Al‐Khatib

    93 How to Avoid Complications of Mapping and Ablation 1161
    David E. Haines

    94 Summary and Consensus of Guidelines for Cardiac Mapping and Ablation 1174
    David Spragg and Hugh Calkins

    95 A Roadmap to a Non‐invasive Radiosurgical Approach to Ablate the Pulmonary Vein Antra for an Effective Treatment of Atrial Fibrillation: Basic and Technical Principles 1182
    Javad Rahimian, Artour Torossian, and Mohammad Shenasa

    96 Future of Cardiac Mapping 1193
    Douglas L. Packer and Deepak Padmanabhan

    97 The Evolution of Cardiac Mapping: Past, Present, Future 1212
    Mohammad Shenasa, Atul Verma, and Kumaraswamy Nanthakumar

    Epilogue by Denis Noble 1228

    Index 1229

Cardiac Mapping

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    A Hardback by Mohammad Shenasa, Gerhard Hindricks, David J. Callans

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      Publisher: John Wiley and Sons Ltd
      Publication Date: Publication Date: 02/05/2019
      ISBN13: 9781119152590, 978-1119152590
      ISBN10: 1119152593

      Description

      Book Synopsis

      The expanded guide to cardiac mapping

      The effective diagnosis and treatment of heart disease may vitally depend upon accurate and detailed cardiac mapping. However, in an era of rapid technological advancement, medical professionals can encounter difficulties maintaining an up-to-date knowledge of current methods. This fifth edition of the much-admired Cardiac Mapping is, therefore, essential, offering a level of cutting-edge insight that is unmatched in its scope and depth.

      Featuring contributions from a global team of electrophysiologists, the book builds upon previous editions? comprehensive explanations of the mapping, imaging, and ablation of the heart. Nearly 100 chapters provide fascinating accounts of topics ranging from the mapping of supraventricular and ventriculararrhythmias, to compelling extrapolations of how the field might develop in the years to come. In this text, readers will find:

      • Full coverage of all aspects of c

        Table of Contents

        About the Companion Website and Companion Digital Edition xii

        List of Videos xiii

        List of Contributors xvi

        Editors of Previous Editions xxxiv

        Preface to the Fifth Edition xxxv

        Preface to the First Edition xxxvi

        Foreword by Douglas P. Zipes and A. John Camm xxxvii

        Part I Fundamentals of Cardiac Mapping

        1 History of Cardiac Mapping 1
        Stephan Zellerhoff, Lars Eckardt, and Gunter Breithardt

        2 Embryology, Anatomy, and Pathology of Ventricular Outflow Tracts Related to Cardiac Mapping and Arrhythmias 7
        Bastiaan J.D. Boukens, Cristina Basso, Federico Migliore, Stefania Rizzo, and Gaetano Thiene

        3 Arrhythmogenic Venous Extremity of the Cardiac Tube 29
        Marco Galeazzi

        4 The Impact of Embryology and Anatomy on Cardiac Electrophysiology 37
        Maxim Didenko and Fred Kusumoto

        5 Cardiac Morphology Relevant to Mapping 46
        Niyada Naksuk, Vaibhav R. Vaidya, Nirusha Lachman, and Samuel J. Asirvatham

        6 Anatomy of the Outflow Tract Region: Relevance to Arrhythmias and Catheter Ablation 61
        Andres Enriquez, Jason Bradfield, Kalyanam Shivkumar, and Fermin C. Garcia

        7 Fundamentals of Cardiac Mapping 70
        Fu Siong Ng, Caroline Roney, Chris D. Cantwell, and Nicholas S. Peters

        8 Troubleshooting to Avoid Failed Ablation 84
        Krishna Kancharla, Suraj Kapa, and Samuel J. Asirvatham

        Part II Imaging Technologies in Cardiac Mapping and Ablation

        9 Intracardiac Echocardiography 95
        Pasquale Santangeli, Mathew D. Hutchinson, and David J. Callans

        10 Role of Cardiac Computed Tomography Imaging to Guide Catheter Ablation of Arrhythmias in Complex Cardiac Morphologies 104
        Farhood Saremi

        11 Role of Cardiac Magnetic Resonance Imaging and Late Gadolinium Enhancement in Relation to Arrhythmias in Different Cardiomyopathies 123
        John Duell and Timm Dickfeld

        12 Multimodal Imaging for Cardiac Mapping 136
        Donald D. Hegland, Kevin P. Jackson, and James P. Daubert

        13 Light and the Heart: Cardiac Optogenetics 152
        Naim Shaheen, Amit Gruber, and Lior Gepstein

        14 Cardiac Mapping and Imaging in Patient Selection for Cardiac Resynchronization Therapy: How to Identify Super‐responders, Responders, and Non‐responders 170
        Bettina Kirstein and Christopher Piorkowski

        Part III Advances in Technology

        15 Towards Non‐invasive Mapping and Imaging of Cardiac Arrhythmias 180
        Edgard A. Prihadi, Victoria Delgado, and Jeroen J. Bax

        16 New High‐Density and Automated Mapping Systems 197
        Albert Y. Sun, Jonathan P. Piccini, and James P. Daubert

        17 Non‐invasive Body Surface Potential Mapping of Reentrant Drivers in Human Atrial Fibrillation 211
        Ruairidh Martin, Meleze Hocini, Remi Dubois, Nicholas Derval, Pierre Jais, and Michel Haissaguerre

        18 Electrophysiology of Heart Failure: Non‐invasive Mapping of Substrate and Guidance of Cardiac Resynchronization Therapy with Electrocardiographic Imaging 220
        Yoram Rudy

        19 Contact Mapping and Ablation of Complex Cardiac Arrhythmias 236
        Sanjiv M. Narayan, Junaid A.B. Zaman, Chad Brodt, Fatemah Shenasa, Tina Baykaner, and Wouter‐Jan Rappel

        20 Advances in Atrial Fibrillation Ablation 252
        Atul Verma and Mohammad Shenasa

        21 Integration of Contact Force into Mapping and Ablation Systems: Does It Improve the Results? 289
        Waqas Ullah and Richard Schilling

        22 Advances in Molecular Imaging Relevant to Arrhythmias 300
        Arnold F. Jacobson and Jagat Narula

        Part IV Mapping in Experimental Models of Cardiac Arrhythmias

        23 Optical Mapping of Sarcoplasmic Reticulum Ca2+ and Transmembrane Potential in the Intact Heart: Insights into Ca2+‐mediated Arrhythmias 313
        Lianguo Wang and Crystal M. Ripplinger

        24 Electrophysiological Substrates for Gender Difference in the Incidence of Torsades de Pointes Arrhythmias 321
        Nabil El‐Sherif , Herman D. Himel, Yuan Yue, Mohamed Boutjdir , and Mark Restivo

        25 Rotors in Animal Models of Atrial Fibrillation 330
        Omer Berenfeld, David Filgueiras‐Rama, and Makarand Deo

        26 Atrial Fibrillation from a Unipolar, High‐resolution Perspective 343
        Natasja M.S. de Groot, Maurits A. Allessie, Lisette J.M.E. van der Does, and Ad J.J.C. Bogers

        27 Mechanisms Underlying Arrhythmogenesis in the J‐wave Syndromes 351
        Eleonora Savio‐Galimberti, Mariana Argenziano, and Charles Antzelevitch

        28 Relationship Between Cardiac Alternans, Calcium Cycling, and Ventricular Arrhythmias 364
        James N. Weiss and Zhilin Qu

        29 Fibrosis and Arrhythmogenesis 375
        Andre G. Kleber and Michiel J. Janse

        30 Triggered Ventricular Tachyarrhythmias Initiated by Enhanced Late Inward Na and Ca Currents: Novel Therapeutic Targets 383
        Hrayr S. Karagueuzian

        31 Experimental VT: A New Porcine Model of Infarct‐related Reentrant VT 398
        Elad Anter, Andrew L. Wit, and Mark E. Josephson

        32 Experimental Mapping of Ventricular Arrhythmias: Intramural Pathways and Substrate 408
        Nigel A. Lever, Ian J. LeGrice, Darren A. Hooks, Mark L. Trew , Bryan J. Caldwell, and Bruce H. Smaill

        33 The Molecular Basis of Long QT Type 2 (LQT2)‐related Arrhythmias: How Sex Modifies the Risk of Torsades de Pointes 422
        Jan Němec, Jong J. Kim, and Guy Salama

        34 Optical Mapping of Arrhythmogenic Remodeling in the Failing Human Heart 431
        Fu Siong Ng, Jaclyn A. Brennan, and Igor R. Efimov

        35 Optical Mapping of Successful and Failed Defibrillation 448
        Kedar K. Aras, Bastiaan J.D. Boukens, Crystal M. Ripplinger, Christopher R. Gloschat, and Igor R. Efimov

        36 Atrial Patterns of Neurally Induced Repolarization Changes: Neuroablative Studies in Canines 464
        Rene Cardinal and Pierre Page

        Part V Mapping and Imaging in Atrial Fibrillation, Flutter, and Atrial Tachycardias

        37 Clinical Relevance of Functional Models of Atrial Reentry and Fibrillation 473
        Stanley Nattel and Vincent Algalorrondo

        38 Rotor Mapping in Patients with Atrial Fibrillation 482
        Sanjiv M. Narayan, Tina Baykaner, Chad Brodt, Junaid A.B. Zaman, Christopher A.B. Kowalewski, David Vidmar, and Wouter‐Jan Rappel

        39 Rotor Mapping and Ablation in Persistent Atrial Fibrillation 496
        Yenn‐Jiang Lin, Men‐Tzung Lo, Li‐Wei Lo, Fa‐Po Chung, and Shih‐Ann Chen

        40 Mapping and Ablation of Atrial Flutter and its Variants 506
        Gregory K. Feld, Jonathan Hsu, Gautam Lalani, and Amir Schricker

        41 Mapping and Ablation of Left Atrial Flutter and Tachycardia: New Observations 530
        Philipp Sommer and Gerhard Hindricks

        42 Mapping and Ablation of Atrial Tachycardia 538
        Karoly Kaszala, Jayanthi Koneru, and Kenneth A. Ellenbogen

        43 Image‐based Risk Stratification for Stroke in Atrial Fibrillation 553
        Jorge Romero, David Briceno, Carola Gianni, Sanghamitra Mohanty , Andrea Natale, Mario Garcia, and Luigi Di Biase

        44 Revisiting Non‐pulmonary Vein Triggers 565
        Carola Gianni, Javier E. Sanchez, Amin Al‐Ahmad, Rodney P. Horton, Patrick M. Hranitzky, J. David Burkhardt, Sanghamitra Mohanty, Chintan Trivedi, Luigi Di Biase, and Andrea Natale

        45 Mechanisms of Antifibrillatory Agents for Atrial Fibrillation: Evidence Obtained from Experimental Models 580
        Gerrit Frommeyer and Lars Eckardt

        46 Stepwise Approach to Atrial Fibrillation Mapping and Ablation in Persistent and Long‐standing Persistent Atrial Fibrillation: Short‐ and Long‐term Results 587
        Julia Vogler, Boris A. Hoffmann, Daniel Steven, Christian Meyer, Benjamin Schaeffer, Doreen Schreiber, Arian Sultan, Thomas Rostock, and Stephan Willems

        47 Mapping and Ablation of the Cardiac Autonomic Nervous System to Treat Atrial Fibrillation 594
        Stavros Stavrakis, Paul Garabelli, Benjamin J. Scherlag, and Sunny S. Po

        48 Remodeling in Atrial Fibrillation: Novel Mapping Studies 604
        Thomas H. Everett IV and Jeffrey E. Olgin

        49 Magnetic Resonance Imaging Mapping of Atrial Fibrosis and Atrial Fibrillation 618
        Leenhapong Navaravong and Nassir F. Marrouche

        50 Fibrotic Atrial Cardiomyopathy: Implications for Ablation of Atrial Fibrillation 628
        Hans Kottkamp, Andreas Rieger, Fabian Moser, and Christian Poenisch

        51 Mapping and Ablation of the Left Atrial Appendage 635
        Anthony J. Choi and Moussa Mansour

        52 Electrogram‐based Mapping and Ablation in Atrial Fibrillation 643
        Ayman A. Hussein and Walid Saliba

        53 Phase Mapping of Human Atrial Fibrillation 652
        Mohammed Saeed, Omer Berenfeld, and Hakan Oral

        54 Trials on Atrial Fibrillation Mapping and Ablation 660
        Antonio Sorgente and Riccardo Cappato

        Part VI Mapping of Supraventricular Arrhythmias

        55 Entrainment Mapping in Supraventricular Tachycardias 665
        John M. Miller, Rahul Jain, Gopi Dandamudi, Seeongwook Han, and Thomas R. Kambur

        56 The Problematic Postpacing Interval 678
        John M. Miller, Rahul Jain, Gopi Dandamudi, Seeongwook Han, and Thomas R. Kambur

        57 Mapping and Ablation of Typical and Atypical Accessory Pathways 689
        James P. Daubert and Edward Sze

        58 Preexcited Atrioventricular Junctional Reentrant Tachycardia: Electrophysiological Characteristics of the Reentrant Circuits 717
        Mohammad‐Reza Jazayeri and Mohammad‐Ali Jazayeri

        59 Mapping and Ablation of Atrioventricular Nodal Reentry Tachycardia and its Variants: Current Understanding and Controversies 751
        Demosthenes G. Katritsis and Mark E. Josephson

        60 Electrical Stimulation Maneuvers to Differentiate Different Forms of Supraventricular Tachycardias 766
        Kevin Ng, George J. Klein, Allan C. Skanes, Lorne J. Gula, Raymond Yee, Jaimie Manlucu, and Peter Leong‐Sit

        61 Mechanisms of Persistent Atrial Fibrillation: What Do the Clinical Mapping Studies Teach Us? 780
        Tomos E. Walters, Geoffrey Lee, and Jonathan M. Kalman

        62 Imaging and Mapping of Arrhythmias in Hypertrophic Cardiomyopathy 798
        Mark S. Link, Christopher Phelan, Mohamed Aljaabari, and N. A. Mark Estes, III

        63 Mapping and Ablation of Supraventricular Arrhythmias in Congenital Heart Disease 809
        Paul Khairy

        64 Cardiac Mapping and Imaging: Arrhythmias in Patients with Congenital Heart Disease 824
        Sabine Ernst

        Part VII Mapping and Imaging of Ventricular Arrhythmias

        65 Mapping and Ablation of Ventricular Tachycardia in Normal Hearts 833
        David J. Callans, Fermin C. Garcia, and Pasquale Santangeli

        66 The Combination of a Basket Catheter and EnSite™ Mapping System Improves Catheter Ablation of Right Ventricle Outflow Premature Ventricular Contraction 843
        Takashi Tokano and Yuji Nakazato

        67 Mapping and Ablation of Ventricular Arrhythmias: Patients with Non‐Ischemic Cardiomyopathy 854
        Roy M. John and William G. Stevenson

        68 Mapping and Ablation of Ventricular Arrhythmias in Patients with Congenital Heart Disease 864
        Elizabeth DeWitt and Edward P. Walsh

        69 Substrate Ablation for Ventricular Tachycardia in Structural Heart Disease 881
        Jorge Romero, David Briceno, Carola Gianni , Sanghamitra Mohanty , J. David Burkhardt , Soo Kim, Amin Al‐Ahmad, Andrea Natale , and Luigi Di Biase

        70 Coronary Mapping and Ablation of Arrhythmias 894
        Sercan Okutucu and Ali Oto

        71 Endocardial Catheter Pace Mapping of Ventricular Tachycardias 901
        Mithilesh K. Das, John M. Miller, Deepak Bhakta, Gopi Dandamudi, and Thomas R. Kambur

        72 Resetting and Entrainment Phenomena: Application to Mapping of Ventricular Tachycardia 911
        Mark E. Josephson, Jesus Almendral, Eduardo Castellanos, Teresa Barrio‐Lopez, and Mercedes Ortiz

        73 Mapping and Ablation of Idiopathic Ventricular Fibrillation 922
        Ghassen Cheniti, Meleze Hocini, Nathaniel Thompson, Arnaud Denis, Josselin Duchateau, Ruairidh Martin, Masateru Takigawa, Antonio Frontera, Gregoire Massoullie, Konstantinos Vlachos, Takeshi Kitamura, Michael Wolf, Nicolas Derval, Frederic Sacher, Pierre Jais, Remi Dubois, and Michel Haissaguerre

        74 Mapping and Ablation in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy: Epicardial and Endocardial Mapping and Long‐Term Results 934
        Fabrizio Assis and Harikrishna Tandri

        75 Mapping and Ablation of Ventricular Arrhythmias in Patients with Cardiac Sarcoidosis 947
        Matthew M. Zipse, Wendy S. Tzou, and William H. Sauer

        76 Cardiac Mapping and Imaging in Patients with Ventricular Arrhythmias in Chagas Disease Undergoing Catheter Ablation of Ventricular Tachycardia 960
        Cristiano Faria Pisani, Mauricio Scanavacca, and Andre D’Avila

        77 Magnetic Resonance Imaging Mapping of Ventricular Tachycardia in Patients with Different Cardiomyopathies (Arrhythmogenic Right Ventricular Dysplasia, Amyloidosis, etc.) 970
        Jonathan Chrispin and Saman Nazarian

        78 Mapping and Ablation of Ventricular Arrhythmias of Unusual Sites 978
        Srikant Duggirala and Edward P. Gerstenfeld

        79 Mapping and Ablation of Ventricular Tachycardia in Coronary Artery Disease 992
        Tanyanan Tanawuttiwat and Joseph E. Marine

        80 Epicardial Mapping in Different Ventricular Tachycardia Substrates: Technique and Instrumentation, Short‐ and Long‐term Results 1007
        Henry H. Hsia and Zhenning Nie

        81 Usefulness of the 12‐Lead ECG to Identify Epicardial Ventricular Substrate and Epicardial Ventricular Tachycardia Site of Origin 1028
        Victor Bazan and Francis E. Marchlinski

        82 Mapping and Imaging of Fascicular Ventricular Tachycardia 1050
        Rakesh Latchamsetty and Frank Bogun

        83 Scar‐Related Ventricular Tachycardia Mapping and Ablation Using Contrast‐Enhanced Magnetic Resonance Imaging 1062
        Antonio Berruezo, Juan Fernandez‐Armenta, Diego Penela, Juan Acosta, Josep Brugada, Lluis Mont , and Beatriz Jauregui

        Part VIII Future Directions and Technologies in Cardiac Mapping and Imaging of Cardiac Arrhythmias

        84 Myocardial Elastography 1073
        Elisa Konofagou

        85 Electromechanical Wave Imaging 1083
        Elisa Konofagou

        86 Principles of Diffusion Tensor Imaging of the Myocardium: Clinical Applications 1096
        Mohammad Shenasa, Hossein Shenasa, and Javad Rahimian

        87 Diffusion Magnetic Resonance Imaging Tractography of the Heart 1113
        Choukri Mekkaoui and David E. Sosnovik

        88 Molecular Magnetic Resonance Imaging in Cardiac Electrophysiology 1124
        David E. Sosnovik

        89 Real‐Time MRI Mapping and Ablation 1132
        Sebastian Hilbert, Philipp Sommer, Ingo Paetsch, Cosima Jahnke, and Gerhard Hindricks

        90 Robotic Navigation for Atrial Fibrillation: Mapping and Ablation 1137
        Jonathan S. Steinberg and Robert Altman

        91 Mapping and Ablation in Patients with VT Storm: Role of Neuraxial Therapeutics 1140
        Olujimi A. Ajijola, Kalyanam Shivkumar, and Marmar Vaseghi

        92 Appropriateness of Mapping and Imaging Modalities in Interventional Electrophysiology 1152
        Emily P. Zeitler and Sana M. Al‐Khatib

        93 How to Avoid Complications of Mapping and Ablation 1161
        David E. Haines

        94 Summary and Consensus of Guidelines for Cardiac Mapping and Ablation 1174
        David Spragg and Hugh Calkins

        95 A Roadmap to a Non‐invasive Radiosurgical Approach to Ablate the Pulmonary Vein Antra for an Effective Treatment of Atrial Fibrillation: Basic and Technical Principles 1182
        Javad Rahimian, Artour Torossian, and Mohammad Shenasa

        96 Future of Cardiac Mapping 1193
        Douglas L. Packer and Deepak Padmanabhan

        97 The Evolution of Cardiac Mapping: Past, Present, Future 1212
        Mohammad Shenasa, Atul Verma, and Kumaraswamy Nanthakumar

        Epilogue by Denis Noble 1228

        Index 1229

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