Description
Book SynopsisThis book provides comprehensive insights into emerging trends on calcium signaling in the nervous system from triggering signal transduction neuronal pathways to regulation of brain functions. Calcium signaling is one of the major coupling mechanism linking external stimuli with intracellular processes. Normal calcium signaling is important for functioning of all cells particularly neurons coupled to control mechanisms of the body inducing intra- and intercellular signaling and triggering biochemical cascade to control metabolism, gene expression, cell differentiation and apoptosis. The author, Dr. Victor V. Chaban is Professor of Medicine with dual appointment at Charles R. Drew University of Medicine and Science (CDU) and University of California Los Angeles (UCLA). Dr. Chaban completed his post-doctoral training in Neuroscience at UCLA and graduate studies in Clinical Research at CDU. He serves on National Institute of Health and several international study sections and holds U.S. Patents. Prof. Chaban is established expert, who contributed significantly to a better understanding of neuroplasticity and neurodegeneration associated with changes in calcium signaling. Calcium Signaling and Nervous System: Overview and Directions for Research gives an up to date account of changes in intracellular Ca2+ associated with primary afferents sensitization, neuronal and glial reorganization, neuroprotection and neurodegeneration. This book is recommended to scientists, healthcare providers, students and patients.
Table of ContentsPreface; Introduction; Role of Calcium Signaling in Peripheral Sensitization of Primary; Afferent Sensory Neuron; Role of Group II Metabotropic Glutamate Receptors in Estrogen: Attenuations of ATP- induced Ca2+ Signaling in Sensory Neurons; Interaction Between Purinergic (P2X3) and Estrogen (ERα/ERβ): Receptors in ATP-mediated Calcium Signaling in Sensory Neurons; Calcium Communication Between Neuroblastoma SH-SY5Y and Primary Sensory Neurons; Calcium Signaling and Sensory Neuronal Reorganization; Role of TRPV1 and P2X2/3 Receptors in Ca2+ mediated Nociception 32 in Visceral Sensory Neurons; Calcium Signaling in Astrocytes; Calcium Signaling in Visceral Nociception; Calcium Signaling in Chronic and Neuropathic Pain; Calcium Signaling and Regulation of Brain Function; Index.
