Description
Book SynopsisThe importance of bone marrow transplantation for patients who do not have a matched sibling donor cannot be overestimated. This subject has always been in the public domain, accentuated by dramatic appeals, from time to time, to search for matched volunteer donors in the public at large. Unfortunately, the availability of such donors is limited, due to the remarkable genetic diversity of humans. Thus, although registries of such volunteers now include more than eight million individuals, we still face the problem of finding a matched donor for about 30% of patients in need. To address this burning issue, extensive clinical and basic research is performed in leading institutes around the world.This book presents updated accounts of the different aspects of this research. The scope of the book is very wide, including strategies to overcome graft vs. host (GVH) disease and graft rejection, cell therapy to prevent leukemia relapse, and a range of modalities to improve immune reconstitution after transplantation. In addition, new approaches to induce immune tolerance towards organ transplants by means of hematopoietic stem cell transplantation are extensively reviewed.
Table of ContentsHaploidentical Allogeneic Hematopoietic Cell Transplantation in Adults Using CD3/CD19 Depletion and Reduced Intensity Conditioning; The Challenge in Hematopoietic Stem Cell Transplantation: Shortening the Immunodeficiency Period; Hematopoietic Stem Cell Transplantation Across Genetic Barriers Using Nonmyeloablative Conditioning Regimen; Adoptive Immunotherapy for Prophylaxis and Therapy of Infectious Complications Post-Allogeneic Hematopoietic Stem Cell Transplantation (HSCT); Alloreactive T Cells for the Treatment of Leukemia; The Role of the Thymus in Hematopoietic Stem Cell Transplantation; Treatment of Adenovirus Infection After Haploidentical Stem Cell Transplantation in Children; Regulatory T-Cell Therapy for Immunomodulation After Allogeneic Hematopoietic Cell Transplantation; Human T-Cell Differentiation: New Techniques - Old Challenges; Optimizing Adoptive T-Cell Therapy Following Allogeneic Hematopoietic Stem Cell Transplantation; Hematopoietic Cell Transplantation for Induction of Transplantation Tolerance: From Animal Models to Clinical Trials.
