Description
Book SynopsisBioreactors: Animal Cell Culture Control for Bioprocess Engineering presents the design, fabrication, and control of a new type of bioreactor meant especially for animal cell line culture. The new bioreactor, called the see-saw bioreactor, is ideal for the growth of cells with a sensitive membrane. The see-saw bioreactor derives its name from its principle of operation in which liquid columns in either limb of the reactor alternately go up and down. The working volume of the reactor is small, to within 15 L. However, it can easily be scaled up for large production in volume of cell mass in the drug and pharmaceutical industries.
The authors describe the principle of operation of the see-saw bioreactor and how to automatically control the bioprocess. They discuss different control strategies as well as the thorough experimental research they conducted on this prototype bioreactor in which they applied a time delay control for yield maximization.
To give
Table of Contents
Introduction. Novel see-saw bioreactor. Simulation of bioprocess and development of BIPROSIM: A general purpose simulation program. Dynamic optimization of a bioprocess using genetic algorithm. Bioprocesses and time delay control. Experimentation on the bioreactor. General conclusion and future scope of research.
