Description
Book SynopsisBiophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays. This book provides an overview of the biophysical methods applied in drug discovery today, including traditional techniques and newer developments. Perspectives from academia and industry across a spectrum of techniques are brought together in a single volume. Small and biotherapeutic approaches are covered and strengths and limitations of each technique are presented. Case studies illustrate the application of each technique in real applied examples. Finally, the book covers recent developments in areas such as electron microscopy with discussions of their possible impact on future drug discovery. This is a go-to volume for biophysicists, analytical chemists and medicinal chemists providing a broad overview of techniques of contemporary interest in drug discovery.
Trade ReviewThe techniques highlighted in this volume are introduced with concise theoretical background that prepares the reader for subsequent illustrative examples from the literature. The theoretical and methodological information is rather limited, but the reader is directed to useful references for further reading. This book will be helpful for medicinal, synthetic, and biophysical chemists urveying an array of tools for their specific drug discovery projects, especially to those who do not want to be inundated with theoretical details. Even though most chapters in this book are written in a manner suitable for an audience with intermediate to advance knowledge of biophysics, Chapter1 will pique the interest of beginners in the field, and is a nice introductory reading for medicinal chemistry graduate students, as it provides a historical perspective and overview of biophysical techniques used at various phases of the drug discovery workflow, namely, hit generation, validation, and drug structure optimization. -- Professor Ian Mitchelle de Vera, Saint Louis University School of Medicine, USA * DOI: 10.1002/cmdc.201800207 *
Table of ContentsImpact and Evolution of Biophysics in Medicinal Chemistry; Ligand-Detected NMR Methods in Drug Discovery; Receptor based NMR techniques in Drug Discovery; Molecular Mechanisms of Drug Action: X-ray Crystallography at the Basis of Structure-based and Ligand-based Drug Design; Mass Spectrometry in Biophysics: from High Throughput Screening to Structural Biology; Characterization of Pharmaceutical Solids Combining NMR, X-ray Diffraction and Computer Modelling; Surface Plasmon Resonance for Identifying and Characterising Small Molecule Ligands; Fluorescent Thermal Shift Assays for Identifying Small Molecule Ligands; Fluorescent Probes in Medicinal Chemistry; Transmission Cryo-Electron Microscopy in Drug Discovery; Molecular Imaging; Subject Index
