Description
Book SynopsisBiochemistry Primer for Exercise Science, Fourth Edition, presents an introduction to biochemistry that gives readers insight into the molecular aspects of physical activity. The fourth edition features updated research and new information on signaling pathways and the regulation of gene expression.
Trade Review"This welcome update of the previous edition includes the most recent peer-reviewed literature that examines exercise science in conjunction with the basic sciences. The authors are well-respected scientists in the field and their expertise, in combination with the updated literature, results in a current and trusted information source for this area.”
--Doody’s Book Review (5-star review)
Table of ContentsPart I: Proteins and Enzymes: The Basis of Biochemistry
Chapter 1: Amino Acids, Peptides, and Proteins
Nature of Amino Acids
Characteristics of Peptides
Structure of Proteins
Next Stage: Proteomics
Summary
Review Questions
Chapter 2: Enzymes
Enzymes as Catalysts
Rates of Enzymatic Reactions
Enzyme Cofactors
Classification of Enzymes
Protein Transporters
Oxidations and Reductions
Regulation of Enzyme Activity
Measurement of Enzyme Activity
Next Stage: Redox Regulation of the SERCA Pump in Vascular Physiology and Disease
Summary
Review Questions
Chapter 3: Gene Transcription and Protein Synthesis
DNA and RNA
Transcription
Posttranscriptional Modifications of RNA
Translation
Posttranslational Processing of Polypeptides
Protein Degradation
Regulation of Gene Expression in Exercise and Training
Next Stage: MicroRNAs and the Adaptive Response to Exercise Training
Summary
Review Questions
Part II: Metabolism: Regulation and Adaptation to Exercise and Training
Chapter 4: Energy Systems and Bioenergetics
Energy Requirements of Skeletal Muscle
Energy-Rich Phosphates
Energy Systems
Bioenergetics
Next Stage: Epigenetic Control of Skeletal Muscle Fiber Type and Metabolic Potential
Summary
Review Questions
Chapter 5: Oxidative Phosphorylation
Overview of Metabolism
Mitochondria
Citric Acid Cycle
Electron Transport Chain
Coupled Phosphorylation
Regulation of Oxidative Phosphorylation
Quantification of Redox Reactions
Oxidants and Antioxidants
Next Stage: Effects of Aging and Exercise Training on Muscle Mitochondria
Summary
Review Questions
Chapter 6: Carbohydrate and Related Metabolism
Carbohydrates
Cellular Uptake of Glucose
Phosphorylation of Glucose
Glycolysis
Glycogen Metabolism
Lactate Metabolism
Oxidation of Cytoplasmic NADH
Gluconeogenesis
Pentose Phosphate Pathway
Signaling Pathways
Next Stage: Carbohydrate, Exercise Performance, and Fatigue
Summary
Review Questions
Chapter 7: Lipid Metabolism
Types of Lipids
Fat Storage and Metabolism
Oxidation of Fatty Acids
Oxidation of Ketone Bodies
Synthesis of Fatty Acids
Fat as Fuel for Exercise
Metabolism During Exercise: Fat Versus Carbohydrate
Adipose Tissue as an Endocrine Tissue
Cholesterol
Next Stage: Exercise, 24-Hour Fat Oxidation, and Weight Loss
Summary
Review Questions
Chapter 8: Amino Acid and Protein Metabolism
Overview of Amino Acid Metabolism
Degradation of Amino Acids
Urea Cycle
Fate of Amino Acid Carbon Skeletons
Amino Acid Metabolism During Exercise
Additional Roles for Amino Acids
Next Stage: Effects of Diet and Exercise on Protein Degradation and Synthesis
Summary
Review Questions
