Description
Book SynopsisBile acids are increasingly being seen as extremely important carcinogenic agents in cancers of the bile duct, liver, colon, rectum, and oesophagus. They are essential agents involved in lipid digestion and absorption in mammals, however, they also play wide-ranging roles in a variety of disease states ranging from diabetes to cancer. They have evolved exquisite mechanisms for controlling their own synthesis and to ensure that they are produced at correct concentrations and also kept in the correct anatomical environment. It is only when these fine levels of controls are breached that Bile acids become associated with disease. This breaching of control mechanisms can occur through dietary means (e.g. in obesity) whereby excessive levels of Bile acids are produced and converted (via the bacterial flora) to damaging secondary Bile acids. Furthermore, lack of re-absorption of Bile acids can lead to liver pathologies. The atypical movement of Bile acids into the oesophagus, stimulated by e
Trade Review"One can only admire the efforts of the editors, who managed to include so many subjects in just over 150 pages, each covered in a short concise text, with each chapter ending with a succinct summary of the main ideas of the chapter, of great help when one wishes to just see the main ideas on one topic such as the way in which bile acids promote carcinogenesis in general, or in a specific part of the gastrointestinal tract." "One can recommend Bile Acids: Toxicology and Bioactivity to everyone who wishes to gain new insights into this field, not only because it represents, even now, one of the few texts available, but also (and mainly) due to its great quality of covering the field in a concise but comprehensive manner. The price might still look steep, but it is clearly worth every penny." -- Radoi Valentin, Carol Davila University of Medicine and Pharmacy, Romania * The Biochemist, Evolution *
Table of ContentsBile acid synthesis; regulation and chemistry; Bile acid physiology and measurement; Bile acids and apoptosis; Bile acid induced Genotoxicity; Bile acids and colorectal cancer; Bile acids and oesophageal cancer Bile acids and obesity Bile acids and cholesterol gallstone formation
