Description
Book SynopsisThis volume details the experimental approaches suitable for isolating and characterizing bacteriophages to formulating bacteriophage medicinal products and clinical application.
Table of ContentsPart I: Isolation of Bacteriophages
1. Isolation of Bacteriophages for Fastidious Bacteria
Shigenobu Matsuzaki, Jumpei Uchiyama, Iyo Takemura-Uchiyama, Takako Ujihara, and Masanori Daibata
2. Isolation of Bacteriophages of the Anaerobic Bacteria Bacteroides
Cristina García-Aljaro, Maite Muniesa, and Juan Jofre
3. Isolation of Bacteriophages for Clinically Relevant Bacteria
Sanna Sillankorva
Part II: Characterization of Bacteriophages
4. In Vitro Activity against Planktonic and Biofilm Populations Assessed by Flow Cytometry
Luís Melo, Diana Priscila Pires, and Joana Azeredo
5. Observation of Bacteriophage Ultrastructure by Cryo-electron Microscopy
Ana Cuervo and José L. Carrascosa
6. Bacteriophage Taxonomy: an Evolving Discipline
Igor Tolstoy, Andrew M. Kropinski, and J. Rodney Brister
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Part III: Bacteriophage Selection and Cocktail Formulation
7. Determination of the Bacteriophage Host Range – Culture Based Approach
Andrey V. Letarov, and Eugene E. Kulikov
8. Recovery and Characterization of Bacteria Resisting Infection by Lytic Bacteriophage
Libera Latino and Christine Pourcel
9. Guidelines to Compose an Ideal Bacteriophage Cocktail
Maia Merabishvili, Jean-Paul Pirnay, and Daniel De Vos
Part IV: Biodistribution, Host Interaction and Clinical Application
10. Interaction of Bacteriophages with Mammalian Cells
Zuzanna Kaźmierczak and Krystyna Dąbrowska
11. In Vivo Bacteriophage Biodistribution
Nicolas Dufour, Raphaëlle Delattre, and Laurent Debarbieux
12. Interaction of Bacteriophages with the Immune System: Induction of Bacteriophage-specific Antibodies
Krystyna Dąbrowska
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13. Bacteriophage Treatment of Infected Diabetic Foot Ulcers
Vera V. Morozova, Yulia N. Kozlova, Denis A. Ganichev, and Nina V. Tikunova
14. Compassionate Use of Bacteriophage Therapy for Foot Ulcer Treatment as an Effective Step for Moving Toward Clinical Trials
Randolph Fisha, Elizabeth Kutter, Gordon Wheat, Bob Blasdel, Mzia Kutateladze, and Sarah Kuhl
Part V: Production, Purification and Bacteriophage Storage
15. Bacteriophage Production in Bioreactors
Maryam Agboluaje and Dominic Sauvage
16. Computational Modelling of Bacteriophage Production for Process Optimization
Konrad Krysiak-Baltyn and Sally L. Gras
17. Methods for Bacteriophage Preservation
Małgorzata B. Łobocka, Aleksandra Głowacka, and Piotr Golec
Part VI: Safety and Regulation
18. Bacteriophage Production in Compliance with Regulatory
Requirements
Jean-Paul Pirnay, Maia Merabishvili, Hilde Van Raemdonck, Daniel De Vos, and Gilbert Verbeken
19. Guidelines for Bacteriophage Product Certification
Alan Fauconnier
Part VII: New Phage Therapy Approaches
20. Nano/micro Formulations for Bacteriophage Delivery
Pilar Cortés, Mary Cano-Sarabia, Joan Colom, Jennifer Otero, Daniel Maspoch, and Montserrat Llagostera
21. Synthetic Biology to Engineer Bacteriophage Genomes
Ana Rita Costa, Catarina Milho, Joana Azeredo, and Diana Priscila Pires
