Description
Book SynopsisWhat is autophagy? Why would neurons digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as an accomplice to cell death in others? By what mechanisms are autophagy-related processes dysregulated in neurological diseases, and are there therapeutic strategies to correct or compensate for their dysfunction? This book provides an expert view of major concepts in autophagy research with a focus on autophagy in neurons. Experimental evidence for evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented, including recent data on braking mechanisms. Areas of intersection with cell death, the ubiquitin-proteasome system, chaperone-mediated autophagy, and the endocytic pathway will be reviewed, along with emerging areas of mitochondrial autophagy (mitophagy) and the autophagic regulation of neuritic/synaptic processes. Advances in delineating mechanisms by which autophagy is involved in the pathophysiology of neurological disorders, including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, ischemia/hypoxia and lysosomal storage diseases, will be discussed along with current drug development strategies targeting autophagy.
Table of ContentsNeuronal Autophagy: Cellular Process and Regulation: Basal Autophagy and Control of Autophagy in Neurons (Z Yue & N Mizushima); Autophagosome Maturation and Neurodegenerative Disease (A Yamamoto & A Simonsen); Cross-Talk Between the Ubiquitin-Proteasome System and Macroautophagy (S Pankiv & T Johansen); Chaperone Mediated Autophagy (CMA) Process in Neurons (M Xilouri et al.); Neuronal Mitochondrial Transport and Turnover via Mitophagy (Z-H Sheng & C T Chu); Autophagy in Axon Homeostasis and Transport (Z Yue); Maintaining Autophagic Balance: A Role for Brakes and Dampers (C T Chu); Autophagy in Neurological Disorders; Autophagy and Its Cross-Talk with Cell Death in Neural Development (S Di Bartolomeo & F Cecconi); Autophagy and Alzheimer's Disease (R Nixon et al.); The Potential of Autophagy Regulation in the Treatment of Neurodegenerative Diseases (A R Winslow et al.); Autophagy - Roles in Synaptic Structure and Function (D Hernandez & D Sulzer); Metabolic Factors for Autophagy in Parkinson's Disease (W H Yu & K Duff); Elucidation of the Autophagy-Lysosomal System of Knockout Mice in Neurons Under Physiologic and Pathologic Conditions (M Komatsu et al.); Lysosome Storage Disorders on the Brain: The Autophagy Lysosome Pathway Contributes to Disease Pathophysiology and May be Utilized for Therapeutic Benefit (J Shacka); Autophagy in the Retina: Development, Physiology and Pathology (P Boya); Autophagy in Amyotrophic Lateral Sclerosis (J Gal & H Zhu); Autophagy and Neurite Degeneration in vitro Models (T Koike & X X Zheng).
