Description
Review
" This book edited by Professors Hamano and Mutoh covers every important aspect of the cutting-edge neurosciences of autophagy in AD and other dementing disorders, including the degradation mechanism of misfolded proteins, A degradation mechanisms by autophagy and endocytosis, degradation mechanisms of tau by autophagy, impairment of mitophagy by A and tau accumulation, propagation of tau by autophagy dysfunction, pathological feature of autophagy, autophagy disturbances in inclusion body myositis and Danon disease, and autophagy defects in other diseases causing dementia, synucleinopathy and Huntington's disease. Perspectives on novel therapeutic strategies for AD, PD, or DLB by modulating autophagy also are widely discussed. I believe this comprehensive monograph on the role of autophagy in neurodegeneration will pave the way toward deeper understanding of the pathophysiology of neurodegenerative dementia and development of novel therapeutic methods to defeat AD and other dementias." --Takeshi Iwatsubo, MD, PhD, Professor and Chair, Department of Neuropathology, Graduate School of Medicine, The University of Tokyo
Table of Contents
Section I. Degradation mechanisms of cells 1. Degradation mechanisms of cells Section II. Lysosomes 2. Lysosomes-neuronal degeneration in lysosomal storage disorders Section III. The autophagic pathways 3. The autophagy pathway and its key regulators Section IV. Amyloid beta protein and autophagy 4. Basics of amyloid beta protein in Alzheimer’s disease 5. Molecular linkages among Aß, tau, impaired mitophagy, and mitochondrial dysfunction in Alzheimer’s disease 6. Endocytosis in ß-amyloid biology and Alzheimer’s disease Section V. Autophagy and tau protein 7. Autophagy and tau protein 8. BAG3 promotes tau clearance by regulating autophagy and other vacuolar-dependent degradative processes 9. Tau propagation and autophagy Section VI. Autophagy and pathology in Alzheimer’s disease 10. Granulovacuolar degeneration in neurodegeneration 11. Autophagy dysfunction in skeletal myopathies: Inclusion body myositis and Danon disease Section VII. Autophagy and other disorders causing dementia 12. Autophagy in Lewy body diseases and multiple system atrophy 13. Autophagy and Huntington’s disease Section VIII. Drug discovery in Alzheimer’s disease by modulating autophagy 14. Drug discovery in Alzheimer’s disease by regulating autophagy 15. Drug discovery in Alzheimer's disease using metal chelators: Warning toward their uses 16. Development of autophagy enhancers for Parkinson's disease therapy
