Description
Book SynopsisThis book illustrates the chemistry, toxicology, and health effects of arsenic using novel modeling techniques, case studies, experimental data, and future perspectives.
Covers exposure sources, health risks, and mechanisms of one of the most toxic minerals in the world
Helps readers understand potential health effects of arsenic, using population studies, mammalian and invertebrate models, and pharmacokinetic and toxicokinetic models
Discusses outcomes, epidemiology, real-life examples, and modes of action for arsenic-induced diseases, like lung cancer, diabetes, cardiovascular and pulmonary diseases, and immunotoxicity
Acts as a reference for toxicologists, environmental chemists, and risk assessors and includes up-to-date, novel modeling techniques for scientists
Includes future perspectives on special topics, like extrapolation from experimental models to human exposures, biomarkers for phenotypic anchoring, and pathology of chronic exposure
Table of ContentsContributors ix
Preface xiii
Part I Fundamentals of Arsenic Exposure and Metabolism 1
1 History of Arsenic as a Poison and a Medicinal Agent 3
Michael F. Hughes
2 Geogenic and Anthropogenic Arsenic Hazard in Groundwaters and Soils: Distribution, Nature, Origin, and Human Exposure Routes 23
David A. Polya and Michael Lawson
3 Remediation of Arsenic in Drinking Water 61
Cathleen J. Webb and Arden D. Davis
4 The Chemistry and Metabolism of Arsenic 81
David J. Thomas
Part II Epidemiology and Disease Manifestations of Arsenic Exposure 111
5 Human Population Studies and Nutritional Intervention 113
Yu Chen and Fen Wu
6 Skin Manifestations of Chronic Arsenicosis 127
Nilendu Sarma
7 Lung Cancer and Other Pulmonary Diseases 137
Cara L. Sherwood and R. Clark Lantz
8 Bladder Cancer and Arsenic 163
Matthew K. Medeiros and A. Jay Gandolfi
9 Neurological Effects of Arsenic Exposure 193
Dominic B. Fee
10 Diabetes Mellitus 221
Miroslav Styblo and Christelle Douillet
11 Hepatotoxicity 249
Gavin E. Arteel
12 Genetic Epidemiology of Susceptibility to Arsenic‐Induced Diseases 267
Mayukh Banerjee and Ashok K. Giri
Part III Mechanisms of Toxicity 289
13 Arsenic Interaction with Zinc Finger Motifs 291
Laurie G. Hudson, Karen L. Cooper, Susan R. Atlas, Brenee S. King and Ke Jian Liu
14 Role in Chemotherapy 315
Koren K. Mann and Maryse Lemaire
15 Genotoxicity 347
Ana Maria Salazar and Patricia Ostrosky‐Wegman
16 Arsenic and Signal Transduction 369
Ingrid L. Druwe and Richard R. Vaillancourt
17 Stem Cell Targeting and Alteration by Arsenic 397
Yuanyuan Xu, Erik J. Tokar and Michael P. Waalkes
18 Epigenetics and Arsenic Toxicity 421
Somnath Paul and Pritha Bhattacharjee
Part IV Models for Arsenic Toxicology and Risk Assessment 439
19 Cancer Induced by Exposure to Arsenicals in Animals 441
Erik J. Tokar, Yuanyuan Xu and Michael P. Waalkes
20 Arsenic‐Induced Cardiovascular Disease 453
Aaron Barchowsky and J. Christopher States
21 Invertebrate Models in Arsenic Research: Past, Present, and Future 469
Iain L. Cartwright
22 Toxicokinetics and Pharmacokinetic Modeling of Arsenic 495
Elaina M. Kenyon and Harvey J. Clewell, III
23 Considerations for a Biologically Based Risk Assessment for Arsenic 511
Harvey J. Clewell, III, P. Robinan Gentry and Janice W. Yager
24 Translating Experimental Data to Human Populations 535
J. Christopher States
Index 549
