Description
Book SynopsisAnimal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.
Table of ContentsForeword Peter Singer Preface Kathrin Herrmann and Kimberley Jayne Acknowledgement Notes on Contributors Introduction Kathrin Herrmann and Kimberley Jayne Part 1: Why and How to Shift the Paradigm 1 Refinement on the Way Towards Replacement: Are We Doing What We Can? Kathrin Herrmann 2 How to Evaluate the Science of Non-human Animal Use in Biomedical Research and Testing: A Proposed Format for Debate Ray Greek and Lisa A. Kramer 3 How Can the Final Goal of Completely Replacing Animal Procedures Successfully be Achieved? Christiane Baumgartl-Simons and Christiane Hohensee 4 Disease Prevention with a Plant-based Lifestyle Sabina Vyas Part 2: Politics and Legislation of Animal Experimentation 5 Political Campaigning: Where Scientific and Ethical Arguments Meet Public Policy Emily McIvor 6 Rethinking the 3Rs: From Whitewashing to Rights Charlotte E. Blattner 7 Contesting Animal Experiments through Ethics and Epistemology: In Defense of a Political Critique of Animal Experimentation Arianna Ferrari Part 3: Openness in Animal Experimentation 8 The Moral Status of Animal Research Subjects in Industry: A Stakeholder Analysis Sarah Kenehan 9 Increasing the Transparency of Animal Experimentation: An Australian Perspective Monika Merkes and Rob Buttrose 10 Wasted Money in United States Biomedical and Agricultural Animal Research Jim Keen Part 4: The Ethics and Philosophy of Animal Experimentation 11 Ethics, Efficacy, and Decision-making in Animal Research Lawrence A. Hansen and Kori Ann Kosberg 12 Beyond Plausibility Checks: A Case for Moral Doubt in Review Processes of Animal Experimentation Mara-Daria Cojocaru and Philipp von Gall 13 Human Wrongs in Animal Research: A Focus on Moral Injury and Reification Jane Johnson and Anna Smajdor Part 5: Effectiveness of the Animal Model 14 Critically Evaluating Animal Research Andrew Knight 15 Extrapolation of Animal Research Data to Humans: An Analysis of the Evidence Rebecca Ram 16 Is Animal-based Biomedical Research being Used in Its Original Context? Constança Carvalho, Daniel Alves, Andrew Knight and Luis Vicente 17 The Scientific Problems with Using Non-human Animals to Predict Human Response to Drugs and Disease Ray Greek and Lisa A. Kramer 18 Replacing Animal Tests to Improve Safety for Humans Kathy Archibald, Robert Coleman and Tamara Drake 19 Genetic Modification of Animals: Scientific and Ethical Issues Jarrod Bailey 20 Animal Research for Alzheimer Disease: Failures of Science and Ethics John J. Pippin, Sarah E. Cavanaugh and Francesca Pistollato 21 Behavioral Research on Captive Animals: Scientific and Ethical Concerns Kimberley Jayne and Adam See Part 6: Animal-free Education and Training 22 Modernizing Biomedical Training: Replacing Live Animal Laboratories with Human Simulation John Pawlowski, David Feinstein, Marie L. Crandall and Shalin Gala 23 Humane Education: The Tool for Scientific Revolution in Brazil Vanessa Carli Bones, Rita de Cassia Maria Garcia, Gutemberg Gomes Alves, Rita Leal Paixão, Alexandro Aluísio Rocha, Karynn Capilé and Róber Bachinski Part 7: The Paradigm Shift: Advanced Animal-free Approaches 24 Recent Developments in Alternatives to Animal Testing Katy Taylor 25 The Changing Paradigm in Preclinical Toxicology: in vitro and in silico Methods in Liver Toxicity Evaluations Fozia Noor 26 The Potential of Organ on Chip Technology for Replacing Animal Testing Malcolm Wilkinson 27 When is an Alternative Not an Alternative? Supporting Progress for Absolute Replacement of Animals in Science Craig Redmond 28 Research and Testing Without Animals: Where are We Now and Where are We Heading? Thomas Hartung Afterword: Evidence Over Interests John P. Gluck Index
