Description
Book SynopsisAlthough the book's primary audience is in the field of genetics, physicians and others without sophisticated training in genetics can understand and apply the principles and techniques discussed.
Trade ReviewFor the last decade this book has been the unrivaled standard text on human genetic linkage analysis. -- J.H. Barrett Biometrics One of the best books that cover the theory behind linkage analysis. Scientists with an interest in genetic linkage analysis should definitely consider allocating space on their bookshelves for this book. Biotech Software and Internet Report A valuable resource. It is the most accessible work on the subject, and should be in the collection of everyone interested in mapping human genes. Doody's Book Review
Table of ContentsList of Illustrations
List of Tables
Preface
List of Symbols and Abbreviations
1. Introduction and Basic Genetic Principles
2. Genetic Loci and Genetic Polymorphisms
3. Aspects of Statistical Inference
4. Basics of Linkage Analysis
5. The Informativeness of Family Data
6. Multipoint Linkage Analysis
7. Penetrance
8. Quantitative Phenotypes
9. Numerical and Computerized Methods
10. Variability of the Recombination Fraction
11. Inconsistencies
12. Linkage Analysis with Mendelian Disease Loci
13. Nonparametric Methods
14. Two-Locus Inheritance
15. Complex Traits
Solutions to Study Problems
References
Index
