Description
Book SynopsisDescribes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. This book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), and Fourier Transform Infrared (FTIR).
Trade Review"…a timely and valuable volume that would be an excellent addition to university libraries and the collections of individuals…" (
E-STREAMS, February 2005)
"...a useful book for chemists entering the field from either analytical or synthetic organic chemistry backgrounds.” (Angewandte Chemie International Edition, September 6, 2004)
"This useful volume is a worthwhile addition to institute libraries as well as to the libraries students and researchers who are working in analytical chemistry, medicinal chemistry, organic chemistry, biotechnology…" (Energy Sources, August 2004)
Table of ContentsPreface.
Contributors.
PART I: ANALYSIS FOR FEASIBILITY AND OPTIMIZATION OF LIBRARY SYNTHESIS.
Chapter 1. Quantitative Analysis in Organic Synthesis with NMR (L. Lucas & C. Larive).
Chapter 2. 19F Gel-phase NMR Spectroscopy for Reaction Monitoring and Quantification of Resin Loading (J. Salvino).
Chapter 3. The Application of Single-Bead FTIR and Color Test for Reaction Monitoring and Building Block Validation in Combinatorial Library Sysnthesis(J. Cournoyer, et al.).
Chapter 4. HR-MAS NMR Analysis of Compounds Attached to Polymer Supports (M. Guinó & Y. de Miguel).
Chapter 5. Multivariate Tools for Real-Time Monitoring and Optimization of Combinatorial Materials and Process Conditions (R. Potyrailo, et al.).
Chapter 6. Mass Spectrometry and Soluble Polymeric Supports (C. Enjalbal, et al.).
PART II: HIGH-THROUGHPUT ANALYSIS FOR LIBRARY QUALITY CONTROL.
Chapter 7. High-Throughput NMR Techniques for Combinatorial Chemical Library Analysis (T. Hou & D. Raftery).
Chapter 8. Micellar Electrokinetic Chromatography as a Tool for Combinatorial Chemistry Analysis: Theory and Applications (P. Simms).
Chapter 9. Characterization of Split-Pool Encoded Combinatorial Libraries (J. Zhang & W. Fitch).
PART III: HIGH-THROUGHPUT PURIFICATION TO IMPROVE LIBRARY QUALITY.
Cha pter 10. Strategies and Methods for Purifying Organic Compounds and Combinatorial Libraries (J. Zhao, et al.).
Chapter 11. HTP of Combinatorial Chemistry Libraries (J. Hochlowski).
Chapter 12. Practical HPLC in High Throughput Analysis and Purification (H. Gumm & R. God).
PART IV: ANALYSIS FOR COMPOUND STABILITY AND DRUGABILITY.
Chapter 13. Organic Compound Stability in Large, Diverse Phatmaceutical Screening Collection (K. Morand & X. Cheng).
Chapter 14. Quartz Crystal Microbalance in Biomolecular Recognition (M. Tseng, et al.).
Chapter 15. High-Throughput Physicochemical Profiling: Potential and Limitations (B. Faller).
Chapter 16. Solubility in the Design of Combinatorial Libraries (C. Lipinski).
Chapter 17. High-Throughput Determination of Log D Values by LC/MS Method (J. Villena, et al.).
Index.
