Description
Book SynopsisIn 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evi
Table of Contents1 Front Matter; 2 Summary; 3 1 Introduction; 4 2 Approach; 5 3 Evaluating Biological Mechanisms of Adverse Events; 6 4 Measles, Mumps, and Rubella Vaccine; 7 5 Varicella Virus Vaccine; 8 6 Influenza Vaccine; 9 7 Hepatitis A Vaccine; 10 8 Hepatitis B Vaccine; 11 9 Human Papillomavirus Vaccine; 12 10 Diphtheria Toxoid, Tetanus Toxoid, and Acellular PertussisContaining Vaccines; 13 11 Meningococcal Vaccine; 14 12 Injection-Related Adverse Events; 15 13 Concluding Comments; 16 Appendix A: Glossary; 17 Appendix B: List of Adverse Events; 18 Appendix C: Literature Search Strategy; 19 Appendix D: Causality Conclusion Tables; 20 Appendix E: References; 21 Appendix F: Committee Biosketches; 22 Appendix G: Meeting Agendas; 23 Index
