Description

Book Synopsis
Volume 143 discusses the main indications of prophylactic oophorectomy, as well as its risks, benefits and impacts on women''s quality of life. Additionally, the authors examine PEGylation, a chemical reaction that allows for the conjugation of a polyethylene-glycol group to another compound. Since the commercial release of adagen, the first approved PEGylated drug, PEGylation has proven to be a successful strategy for the generation of efficient drugs. Following this, this compilation analyses the morphological and functional disorders that may be induced by oxaliplatin. The authors present the possible side effects of this drug upon several organs, as well as the mechanisms that are activated by the nominated drug. The authors also summarise the processes that might be occurring in Werner syndrome cells during DNA replication that then lead to the genomic instability and replication stress and, ultimately, a p38a-induced premature senescence. The results of the authors'' studies combining the granulocyte colony-stimulating factor and enteral sorption therapy are presented in the closing chapter to ameliorate common side effects of such potent and toxic anti-cancer alkylating agents, such as melphalan.

Advances in Medicine and Biology: Volume 143

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    A Hardback by Leon V Berhardt

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      Book details

      Publisher Nova Science Publishers Inc
      Published 21 June 2019
      ISBN-13 9781536158144
      978-1536158144
      ISBN-10 1536158143
      Also in:
      Mathematics Mathematics and Science Medicine / Healthcare: general issues / topics Science & Nature Biology, life sciences Books by Leon V Berhardt

      Description

      Book Synopsis
      Volume 143 discusses the main indications of prophylactic oophorectomy, as well as its risks, benefits and impacts on women''s quality of life. Additionally, the authors examine PEGylation, a chemical reaction that allows for the conjugation of a polyethylene-glycol group to another compound. Since the commercial release of adagen, the first approved PEGylated drug, PEGylation has proven to be a successful strategy for the generation of efficient drugs. Following this, this compilation analyses the morphological and functional disorders that may be induced by oxaliplatin. The authors present the possible side effects of this drug upon several organs, as well as the mechanisms that are activated by the nominated drug. The authors also summarise the processes that might be occurring in Werner syndrome cells during DNA replication that then lead to the genomic instability and replication stress and, ultimately, a p38a-induced premature senescence. The results of the authors'' studies combining the granulocyte colony-stimulating factor and enteral sorption therapy are presented in the closing chapter to ameliorate common side effects of such potent and toxic anti-cancer alkylating agents, such as melphalan.

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