Description

Book Synopsis
A Closer Look at Kinase Inhibition opens with a discussion on the roles of various tyrosine kinases inhibitors and molecular mechanisms of acquired resistance to tyrosine kinase inhibitor drugs therapy in colon-rectal cancer. The authors summarize host cell and viral protein kinases, the progress in their use, and the repurposing of approved kinase inhibitors as broad-spectrum antivirals. The key kinases, namely CLK1, DYRK1A, CDK5, GSK3 and CK1, are analyzed as data indicate that targeting these proteins may have therapeutic promise against Alzheimer's disease.

Table of Contents
PrefaceTargeted Therapy of Tyrosine Kinase Inhibitor Drugs for Two Different Cancers (Colon-Rectal Cancer and Chronic Myelogenous Leukemia) and Their Resistance MechanismsRole of Kinases in Antiviral TherapeuticsIn Search of Novel Tau Kinase Inhibitors and Their Role in Alzheimers TherapyIndex.

A Closer Look at Kinase Inhibition

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    A Hardback by Alex Tompson

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      Publisher: Nova Science Publishers Inc
      Publication Date: 01/03/2020
      ISBN13: 9781536169737, 978-1536169737
      ISBN10: 1536169730
      Also in:
      Science & Nature Chemistry

      Description

      Book Synopsis
      A Closer Look at Kinase Inhibition opens with a discussion on the roles of various tyrosine kinases inhibitors and molecular mechanisms of acquired resistance to tyrosine kinase inhibitor drugs therapy in colon-rectal cancer. The authors summarize host cell and viral protein kinases, the progress in their use, and the repurposing of approved kinase inhibitors as broad-spectrum antivirals. The key kinases, namely CLK1, DYRK1A, CDK5, GSK3 and CK1, are analyzed as data indicate that targeting these proteins may have therapeutic promise against Alzheimer's disease.

      Table of Contents
      PrefaceTargeted Therapy of Tyrosine Kinase Inhibitor Drugs for Two Different Cancers (Colon-Rectal Cancer and Chronic Myelogenous Leukemia) and Their Resistance MechanismsRole of Kinases in Antiviral TherapeuticsIn Search of Novel Tau Kinase Inhibitors and Their Role in Alzheimers TherapyIndex.

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