{"product_id":"zika-virus-and-diseases-9781119408642","title":"Zika Virus and Diseases","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eCompiles the most current information on the Zika virus and its associated diseases\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThis comprehensive book provides the most up-to-date information for students, medical students, and scientists on Zika virus and its associated diseases. It includes all the information related to the Zika virus since its discovery in 1947; its epidemic outbreak in 2007-2014; how the epidemiology changed in America in 2015-2016; its mode of transmission; how to prevent and treat it; and associated diseases.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eZika Virus and Diseases: From Molecular Biology to Epidemiology\u003c\/i\u003e offers complete and up-to-date coverage in 10 chapters. It presents information from papers that attempted to associate the virus with diseases in Africa until the first animal experiment; discusses its association with Guillain-Barré syndrome and microcephaly; describes the basic mechanisms for Zika (ZIKV) replication, including important differences between Dengue (DENV), West-Nile virus (WNV), and ZIKV;\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003ePreface ix\u003c\/p\u003e \u003cp\u003eList of Abbreviations xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 The History of ZIKV Discovery 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 ZIKV Isolation from Monkeys and Mosquitos 1\u003c\/p\u003e \u003cp\u003e1.2 ZIKV Infection in Humans 6\u003c\/p\u003e \u003cp\u003e1.3 ZIKV Infection Spread to Other Hosts and Regions 7\u003c\/p\u003e \u003cp\u003e1.4 Cross‐Paths between ZIKV and Other Flaviviruses 9\u003c\/p\u003e \u003cp\u003eReferences 10\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 ZIKV: From Silent to Epidemic 15\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Outbreak in Yap Island (2007) 15\u003c\/p\u003e \u003cp\u003e2.2 Outbreak in French Polynesia (2013) 16\u003c\/p\u003e \u003cp\u003e2.3 How Did ZIKV Reach Brazil? 18\u003c\/p\u003e \u003cp\u003e2.4 Outbreak in Brazil (2015) 18\u003c\/p\u003e \u003cp\u003e2.5 ZIKV Spread through South, Central, and North Americas 20\u003c\/p\u003e \u003cp\u003eReferences 22\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 ZIKV Transmission and Prevention 29\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Modes of Transmission 29\u003c\/p\u003e \u003cp\u003e3.2 Prevention 37\u003c\/p\u003e \u003cp\u003eReferences 40\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Association with Guillain‐Barre Syndrome and Microcephaly 49\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Association with Neurological Disorders 49\u003c\/p\u003e \u003cp\u003eReferences 58\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 ZIKV Animal Models 69\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Animal Models: Embryonated Hen Eggs 69\u003c\/p\u003e \u003cp\u003e5.2 Animal Models: Landrace Piglet 69\u003c\/p\u003e \u003cp\u003e5.3 Animal Models: Mice 70\u003c\/p\u003e \u003cp\u003e5.4 Animal Model: Nonhuman Primate 74\u003c\/p\u003e \u003cp\u003eReferences 78\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Biology of ZIKV 83\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Structural and Physical Properties of ZIKV Virion 84\u003c\/p\u003e \u003cp\u003e6.2 Binding and Entry 87\u003c\/p\u003e \u003cp\u003e6.3 Genome Structure 89\u003c\/p\u003e \u003cp\u003e6.4 Translation and Proteolytic Processing 91\u003c\/p\u003e \u003cp\u003e6.5 Features of the Nonstructural Proteins 92\u003c\/p\u003e \u003cp\u003e6.6 RNA Replication 100\u003c\/p\u003e \u003cp\u003e6.7 Features of the Structural Proteins 104\u003c\/p\u003e \u003cp\u003e6.8 Virus Assembly and Release from Virus‐Infected Cells 107\u003c\/p\u003e \u003cp\u003eReferences 109\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Zika Virus (ZIKV) Strains and Lineages 131\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 East and West African Lineage 131\u003c\/p\u003e \u003cp\u003e7.2 Africa vs. Asian\/American Lineage 132\u003c\/p\u003e \u003cp\u003eReferences 140\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 ZIKV‐Host Interactions 147\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Systematic Studies to Identify ZIKV Affected Functions and Pathways 147\u003c\/p\u003e \u003cp\u003e8.2 Induction and Dysregulation of Innate Immune Responses during ZIKV Infection 150\u003c\/p\u003e \u003cp\u003e8.3 Induction of Cell Death and Apoptosis by ZIKV 156\u003c\/p\u003e \u003cp\u003e8.4 Induction of Autophagy by ZIKV 160\u003c\/p\u003e \u003cp\u003e8.5 Dysregulation of Cell Cycle and Induction of Abnormal Mitosis by ZIKV 163\u003c\/p\u003e \u003cp\u003eReferences 164\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Inhibitors of ZIKV Replication and Infection 179\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Drugs That Lead to the Destruction of ZIKV Virions 179\u003c\/p\u003e \u003cp\u003e9.2 Drugs That Inhibit ZIKV Entry and Endocytosis 180\u003c\/p\u003e \u003cp\u003e9.3 Drugs That Target ZIKV NS2B‐NS3 Protease Activity 186\u003c\/p\u003e \u003cp\u003e9.4 Drugs That Target ZIKV NS5 RNA‐Dependent RNA Polymerase Activity 191\u003c\/p\u003e \u003cp\u003e9.5 Neutralizing Antibodies That Target ZIKV Structural Protein 200\u003c\/p\u003e \u003cp\u003e9.6 Drugs That Inhibit ZIKV Infection by Targeting Host Machinery 201\u003c\/p\u003e \u003cp\u003e9.7 Drugs That Show Neuroprotective Activity but Do Not Suppress ZIKV Replication: Emricasan 205\u003c\/p\u003e \u003cp\u003e9.8 Other Drugs That Inhibit ZIKV Infection Identified from a Screening of FDA‐Approved Drugs 206\u003c\/p\u003e \u003cp\u003eReferences 210\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Long‐Term Care and Perspectives 229\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Prenatal Care and Diagnosis of Abnormal Fetus Development 229\u003c\/p\u003e \u003cp\u003e10.2 Long‐Term Care for Patients Affected by ZIKV 230\u003c\/p\u003e \u003cp\u003e10.3 Assistance to Families with Children Affected by ZIKV 230\u003c\/p\u003e \u003cp\u003e10.4 Perspectives 231\u003c\/p\u003e \u003cp\u003eReferences 232\u003c\/p\u003e \u003cp\u003eIndex 237\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49407047762263,"sku":"9781119408642","price":103.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781119408642.jpg?v=1730497996","url":"https:\/\/bookcurl.com\/products\/zika-virus-and-diseases-9781119408642","provider":"Book Curl","version":"1.0","type":"link"}