{"product_id":"whats-wrong-with-my-mouse-9780471471929","title":"Whats Wrong With My Mouse","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eDr. Jacqueline N. Crawley, author of the First and Second Editions of \u003ci\u003eWhat's Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,\u003c\/i\u003econtinues to field calls and e-mails from molecular geneticists who ask: \u003ci\u003ehow do I run behavioral assays to find out what's wrong with my mouse?\u003c\/i\u003e  \u003cp\u003eTurn to \u003ci\u003eWhat's Wrong with My Mouse?\u003c\/i\u003e to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters:\u003c\/p\u003e \u003cp\u003eNeurodevelopment and Neurodegeneration discusses mo\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eFirst Edition Reviews:\u003c\/b\u003e  \u003c\/p\u003e\u003cp\u003e\"The book successfully brings together the field of behavioral neuroscience and the rewards and insights that can be gained using this approach. I would recommend that every behavioral scientist has at least two copies, one for their own use and one that will be on permanent load to their students, post-doctoral students and colleagues in molecular biology.\" (\u003ci\u003eTrends in Pharmaceutical Sciences\u003c\/i\u003e)\u003c\/p\u003e \u003cp\u003e\"the overall impression is of a helpful guide taking the reader step by step through the complexities of animal behavioral research.\" (\u003ci\u003eNature Neuroscience\u003c\/i\u003e)\u003c\/p\u003e \u003cp\u003e\"succeeds as a useful introduction to the realm of behavioral phenotyping for those interested in creating or using the large and increasing number of promising targeted mutant mice.\" (\u003ci\u003eTrends in Neurosciences\u003c\/i\u003e)\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePreface ix\u003c\/p\u003e \u003cp\u003ePreface to the First Edition xi\u003c\/p\u003e \u003cp\u003eAcknowledgments xiii\u003c\/p\u003e \u003cp\u003eChapter 1 Designer Mice 1\u003cbr\u003e\u003ci\u003eScope and sourcebooks\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 2 Of Unicorns and Chimeras 10\u003cbr\u003e\u003ci\u003eHow to generate a line of transgenic or knockout mouse for behavioural phenotyping\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 3 General Health 42\u003cbr\u003e\u003ci\u003eGive your mouse a physical\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 4 Motor Functions 62\u003cbr\u003e\u003ci\u003eOpen field, holeboard, rotarod, balance, grip, circadian activity, circling, stereotypy, ataxic gait, seizures\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 5 Sensory Abilities 86\u003cbr\u003e\u003ci\u003eOlfaction, vision, hearing, taste, touch, nociception\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 6 Learning and Memory 110\u003cbr\u003e\u003ci\u003eMorris swim task, spatial mazes, cued and contextual conditioning, conditioned taste aversion, conditioned eyeblink, olfactory discrimination, social recognition, passive avoidance, schedule controlled operant tasks, motor learning, attention\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 7 Feeding and Drinking 164\u003cbr\u003e\u003ci\u003eDaily consumption, restricted access, choice tests, microstructural analysis\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 8 Reproductive Behaviors 186\u003cbr\u003e\u003ci\u003eSexual and parental behaviors\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 9 Social Behaviors 206\u003cbr\u003e\u003ci\u003eSocial interaction, nesting, grooming, juvenile play, aggression\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 10 Emotional Behaviors: Animal Models of Psychiatric Diseases 226\u003cbr\u003e\u003ci\u003eMouse models of fear, anxiety, depression, schizophrenia\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 11 Reward 266\u003cbr\u003e\u003ci\u003eSelf-administration of addictive drugs, conditioned place preference\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 12 Neurodevelopment and Neurodegeneration 290\u003cbr\u003e\u003ci\u003eAssaying behaviors in infant, juvenile, and aged mice\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 13 Putting It All Together 322\u003cbr\u003e\u003ci\u003eChoice of tests, order of testing, number of mice, equipment, housing and testing environment\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 14 The Next Generation 344\u003cbr\u003e\u003ci\u003eConditional and inducible mutations, viral vector gene delivery, RNA silencing, quantitative trait loci analysis, DNA microarrays, chemical mutagenesis, gene therapy, ethical issues\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eReferences 383\u003c\/p\u003e \u003cp\u003eIndex 503\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402605044055,"sku":"9780471471929","price":111.56,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780471471929.jpg?v=1730480931","url":"https:\/\/bookcurl.com\/products\/whats-wrong-with-my-mouse-9780471471929","provider":"Book Curl","version":"1.0","type":"link"}