{"product_id":"the-toxicology-of-methanol-9780470317594","title":"The Toxicology of Methanol","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eA high-volume industrial chemical used in many consumer products, methanol is poisonous at high doses and long-term exposures. This single, comprehensive source of toxicity data describes what we know about the toxic effects of methanol on humans, animals, and the environment.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface xiii  \u003cp\u003eContributors xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Methanol Production and Markets: Past, Present, and Future 1\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eGregory A. Dolan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eReferences 9\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Methanol: Fate and Transport in the Environment 11\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eRula A. Deeb, Todd L. Anderson, Michael C. Kavanaugh, and Lauren A. Kell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 11\u003c\/p\u003e \u003cp\u003e2.2 Partitioning of Methanol in the Environment 16\u003c\/p\u003e \u003cp\u003e2.3 Fate and Transport of Methanol in the Environment 22\u003c\/p\u003e \u003cp\u003e2.4 Methanol Additives 37\u003c\/p\u003e \u003cp\u003e2.5 Conclusions 40\u003c\/p\u003e \u003cp\u003eReferences 40\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Human Toxicity 47\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJohn J. Clary\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 47\u003c\/p\u003e \u003cp\u003e3.2 Exposure 48\u003c\/p\u003e \u003cp\u003e3.3 Metabolism in Humans 50\u003c\/p\u003e \u003cp\u003e3.4 History of Human Toxicity 54\u003c\/p\u003e \u003cp\u003e3.5 Controlled Human Studies 60\u003c\/p\u003e \u003cp\u003e3.6 In Utero Exposure 62\u003c\/p\u003e \u003cp\u003e3.7 Repeat Inhalation Exposure 63\u003c\/p\u003e \u003cp\u003e3.8 Management of Methanol Poisoning 64\u003c\/p\u003e \u003cp\u003e3.9 Conclusions 66\u003c\/p\u003e \u003cp\u003eReferences 67\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 General Animal and Aquatic Toxicity 73\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJohn J. Clary\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 73\u003c\/p\u003e \u003cp\u003e4.2 Acute Toxicity 74\u003c\/p\u003e \u003cp\u003e4.3 Irritation 86\u003c\/p\u003e \u003cp\u003e4.4 Sensitization 87\u003c\/p\u003e \u003cp\u003e4.5 Repeat Exposure—Inhalation 87\u003c\/p\u003e \u003cp\u003e4.6 Repeat Exposure—Oral 94\u003c\/p\u003e \u003cp\u003e4.7 Repeat Exposure—Dermal 96\u003c\/p\u003e \u003cp\u003e4.8 Aquatic Toxicity 96\u003c\/p\u003e \u003cp\u003e4.9 Conclusion 99\u003c\/p\u003e \u003cp\u003eReferences 100\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Developmental and Reproductive Toxicology of Methanol 107\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJohn M. Rogers, Jeffrey S. Gift, and Stanley Barone, Jr\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e5.1 Introduction 107\u003c\/p\u003e \u003cp\u003e5.2 Reproductive Toxicity 108\u003c\/p\u003e \u003cp\u003e5.3 Developmental Toxicity 110\u003c\/p\u003e \u003cp\u003e5.4 Conclusions 136\u003c\/p\u003e \u003cp\u003eDisclaimer 139\u003c\/p\u003e \u003cp\u003eReferences 139\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Exploring Differences Between PBPK Models of Methanol Disposition in Mice and Humans: Important Lessons Learned 145\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eThomas B. Starr\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Background 145\u003c\/p\u003e \u003cp\u003e6.2 Are Humans More or Less Sensitive than Mice to the Toxic Effects of Methanol? 148\u003c\/p\u003e \u003cp\u003e6.3 Are the Two Models’ Predictions of Human Blood Methanol Concentrations at Steady State Consistent with Each Other? 153\u003c\/p\u003e \u003cp\u003e6.4 Are the Values of Key Human Metabolism Parameters Consistent with Those in the Published Scientific Literature? 155\u003c\/p\u003e \u003cp\u003e6.5 Shouldn’t the Possibility of Systematic Bias be Considered Carefully During the Model Fitting and Parameter Estimation Process? 160\u003c\/p\u003e \u003cp\u003e6.6 Is “Visual Optimization” an Adequate Technique for Estimating PBPK Model Parameters? 161\u003c\/p\u003e \u003cp\u003e6.7 When Human Data are Available, Shouldn’t they be Utilized in Making an Objective Comparison of Model-Specific Predictions? 163\u003c\/p\u003e \u003cp\u003e6.8 Summary of Lessons Learned 164\u003c\/p\u003e \u003cp\u003eReferences 165\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Oxidative Stress and Species Differences in the Metabolism, Developmental Toxicity, and Carcinogenic Potential of Methanol and Ethanol 169\u003c\/b\u003e\u003cbr\u003e \u003ci\u003ePeter G. Wells, Gordon P. McCallum, Lutfiya Miller, Michelle Siu, and J. Nicole Sweeting\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 169\u003c\/p\u003e \u003cp\u003e7.2 Species Differences in Methanol Metabolism 179\u003c\/p\u003e \u003cp\u003e7.3 Species and Strain Differences in Methanol Toxicity 191\u003c\/p\u003e \u003cp\u003e7.4 Oxidative Stress 213\u003c\/p\u003e \u003cp\u003e7.5 Conclusions 237\u003c\/p\u003e \u003cp\u003eAcknowledgment 238\u003c\/p\u003e \u003cp\u003eReferences 238\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Methanol and Cancer 255\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJohn J. Clary\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 255\u003c\/p\u003e \u003cp\u003e8.2 Rodent Bioassay 256\u003c\/p\u003e \u003cp\u003e8.3 Possible Mechanisms 270\u003c\/p\u003e \u003cp\u003e8.4 Human Cancer Data 276\u003c\/p\u003e \u003cp\u003e8.5 Conclusion 276\u003c\/p\u003e \u003cp\u003e\u003ci\u003eReferences 277\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eIndex 283\u003c\/i\u003e\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402314719575,"sku":"9780470317594","price":107.06,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470317594.jpg?v=1730480041","url":"https:\/\/bookcurl.com\/products\/the-toxicology-of-methanol-9780470317594","provider":"Book Curl","version":"1.0","type":"link"}