{"product_id":"the-bloodbrain-barrier-9781071622889","title":"The BloodBrain Barrier","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis detailed volume features techniques to explore the complex interface that separates the systemic circulation from the central nervous system, known as the blood-brain barrier (BBB). Beginning with an introduction to its physiology, the book continues with sections on using pluripotent stem cells in models of the BBB, co-culture, permeability and transwell models, microfluidic and chip models, as well as models to study specific BBB pathologies. Written for the highly successful \u003ci\u003eMethods in Molecular Biology\u003c\/i\u003e series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. \u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\u003cdiv\u003eAuthoritative and practical, \u003ci\u003eThe Blood-Brain Barrier: Methods and Protocols\u003c\/i\u003e collects a wide range of methodologies which will aid all researchers in the fascinating world of the blood-brain barrier.\u003c\/div\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003ePart I: \u003c\/b\u003e\u003cb\u003eIntroduction to Blood-Brain Barrier (BBB) Physiology\u003c\/b\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e1. Cells of the Blood-Brain Barrier: An Overview of the Neurovascular Unit in Health and Disease\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Heather L. McConnell and Anusha Mishra\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e2. \u003c\/b\u003e\u003cb\u003eIn Vitro Models of the Blood-Brain Barrier\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Snehal Raut, Aditya Bhalerao, Behnam Noorani, and Luca Cucullo\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003ePart II: Using Pluripotent Stem Cells in Models of the BBB\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e3. In Vitro Models of the Human Blood-Brain Barrier Based on Human Induced Pluripotent Stem Cells: Opportunities and Challenges\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Iqra Pervaiz and Abraham J. Al-Ahmad\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e4. \u003c\/b\u003e\u003cb\u003eInduced Pluripotent Stem Cell (iPSC)-Derived Endothelial Cells to Study Bacterial–Brain Endothelial Cell Interactions\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Eric R. Espinal, S. Jerod Sharp, and Brandon J. Kim\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e5. An hiPSC-Derived In Vitro Model of the Blood-Brain Barrier\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Mary Goodwin-Trotman, Krushangi Patel, and Alessandra Granata\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e6. A Three-Dimensional Brain-on-Chip Using Human iPSC-Derived GABAergic Neurons and Astrocytes\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Lumei Liu, Youngmi Koo, Teal Russell, and Yeoheung Yun\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003ePart III: \u003c\/b\u003e\u003cb\u003eCo-Culture, Permeability, and Transwell Models of the BBB: Methods for Studying Shear Stress, Barrier Integrity and Breakdown\u003c\/b\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e7. An Improved In Vitro Porcine Blood-Brain Barrier Model for Permeability Screening and Functional Studies\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Adjanie Patabendige\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e8. \u003c\/b\u003e\u003cb\u003eEstablishment of an In Vitro\u003ci\u003e \u003c\/i\u003eModel of Human Blood-Brain Barrier to Study the Impact of Ischaemic Injury\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Rais Reskiawan A. Kadir, Mansour Alwjwaj, and Ulvi Bayraktutan\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e9. \u003c\/b\u003e\u003cb\u003eA Novel Dynamic Human In Vitro Model for Studying the Blood-Brain Barrier\u003c\/b\u003e\u003c\/p\u003e              Patricia Miranda-Azpiazu and Sikha Saha\u003cp\u003e\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e10. A Dynamic, In Vitro BBB Model to Study the Effects of Varying Levels of Shear Stress\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Gemma Molins Gutierrez, Jordi Martorell, Antonio G. Salazar-Martin, and Mercedes Balcells\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003ePart IV: \u003c\/b\u003e\u003cb\u003eMicrofluidic and Chip Models of the BBB\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e11. \u003c\/b\u003e\u003cb\u003eNovel, Emerging Chip Models of the BBB and Future Directions\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Paul M. Holloway\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e12. Integrating Primary Astrocytes in a Microfluidic Model of the Blood-Brain Barrier\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Eliana Lauranzano, Marco Rasile, and Michela Matteoli\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e13. Fabrication of Microtube-Embedded Chip to Mimic Blood-Brain Barrier Capillary Vessels\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Dilshan Sooriyaarachchi, Shahrima Maharubin, and George Z. Tan\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e14. \u003c\/b\u003e\u003cb\u003eBBB-on-a-Chip: Modeling Functional Human BBB by Mimicking 3D Brain Angiogenesis Using Microfluidic Chip\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Somin Lee, Minhwan Chung, and Noo Li Jeon\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003ePart V: Models to Study Specific Pathologies at the BBB: Cancer, Neurodegeneration, and More\u003c\/b\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e15. Cell Interplay Model to Assess the Impact of Glioma Cells on Blood-Brain Barrier Permeability\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Cláudia Martins and Bruno Sarmento\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e16. An In Vitro\u003ci\u003e \u003c\/i\u003eHuman Blood-Brain Barrier Model to Study Breast Cancer Brain Metastasis\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Caroline Mysiorek, Lucie Dehouck, Fabien Gosselet, and Marie-Pierre Dehouck\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e17. \u003c\/b\u003e\u003cb\u003eAn In Vivo Mouse Model to Study Blood-Brain Barrier Destabilization in the Chronic Phase of Stroke\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Svetlana M. Stamatovic, Chelsea M. Phillips, Richard F. Keep, and Anuska V. Andjelkovic\u003c\/p\u003e   \u003cp\u003e\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e18. Immunohistochemical Analysis of Tight Junction Proteins\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Chris Greene and Matthew Campbell\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e19. An In Vitro BBB Model to Study Firm Shear-Stress Resistant Leukocyte Adhesion to Human Brain Endothelial Cells\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Camilla Cerutti and Ignacio A. Romero\u003c\/p\u003e  \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003e20. An In Vitro Model of the Blood-Brain Barrier (BBB) to Study Alzheimer's Disease: The Role of \u003c\/b\u003e\u003cb\u003eβ-Amyloid and Its Influence on PBMC Infiltration\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e            Simona Federica Spampinato, Yukio Takeshita, and Birgit Obermeier\u003c\/p\u003e","brand":"Springer-Verlag New York Inc.","offers":[{"title":"Default Title","offer_id":53186413658455,"sku":"9781071622889","price":179.99,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/bookcurl.com\/products\/the-bloodbrain-barrier-9781071622889","provider":"Book Curl","version":"1.0","type":"link"}