{"product_id":"the-biostatistics-of-aging-9781118645857","title":"The Biostatistics of Aging","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eFeaturing a multidisciplinary approach with practical examples from biology, gerontology, and demography,   The Biostatistics of Aging provides a statistical theoretical framework for aging and aging-related diseases in addition to genetic and environmental contributions to mortality.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003ePREFACE AND ACKNOWLEDGMENT ix\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 An Account of Gompertzian Mortality through Statistical and Evolutionary Arguments 6\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 The Statistical Theory of Extreme Values 10\u003c\/p\u003e \u003cp\u003e2.2 The Evolutionary Theory of Aging 36\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 The Argument against Gompertzian Mortality 69\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Departures from the Gompertz Model 70\u003c\/p\u003e \u003cp\u003e3.2 An Evolution-Based Model of Causation 72\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 The Index of Aging-Relatedness 93\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 A Survival Mixture Model of the Gompertz and Weibull Distributions 94\u003c\/p\u003e \u003cp\u003e4.2 Definition and Interpretation of the Index of Aging-Relatedness 97\u003c\/p\u003e \u003cp\u003e4.3 The Survival Mixture Model and Competing Risks 103\u003c\/p\u003e \u003cp\u003e4.4 Estimation of the Model Parameters 107\u003c\/p\u003e \u003cp\u003e4.5 Illustrative Application: The Israeli Ischemic Heart Disease Study 109\u003c\/p\u003e \u003cp\u003e4.6 Precision of Estimation 122\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Discussion: Implications 128\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 The Meaning of the Gompertz Parameter 128\u003c\/p\u003e \u003cp\u003e5.2 Age as a Risk Factor for Disease 132\u003c\/p\u003e \u003cp\u003e5.3 Are Aging-Related Diseases an Integral Part of Aging? 134\u003c\/p\u003e \u003cp\u003e5.4 Biological versus Chronological Aging 135\u003c\/p\u003e \u003cp\u003e5.5 The Public Health Notion of Compression of Morbidity 138\u003c\/p\u003e \u003cp\u003e5.6 A Picture of Aging for the Twenty-First Century 143\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAPPENDIX A: PROOFS OF RESULTS IN SECTION 2.1.2 WITH SOME EXTENSIONS 154\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAPPENDIX B: DERIVATION OF HAMILTON’S EQUATION FOR THE FORCE OF NATURAL SELECTION ON MORTALITY 170\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAPPENDIX C: SOME PROPERTIES OF THE GOMPERTZ AND WEIBULL DISTRIBUTIONS 174\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAPPENDIX D: FIRST AND SECOND PARTIAL DERIVATIVES OF THE MIXTURE LOG-LIKELIHOOD FUNCTION 178\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAPPENDIX E: EXPECTATION–CONDITIONAL MAXIMIZATION (ECM) ALGORITHM 183\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAPPENDIX F: R PROGRAM 190\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eREFERENCES 226\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAUTHOR INDEX 245\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSUBJECT INDEX 253\u003c\/b\u003e\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49406899421527,"sku":"9781118645857","price":89.06,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118645857.jpg?v=1730497490","url":"https:\/\/bookcurl.com\/products\/the-biostatistics-of-aging-9781118645857","provider":"Book Curl","version":"1.0","type":"link"}