{"product_id":"tangled-up-9781914487422","title":"Tangled Up","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cb\u003e\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003e\u003cb\u003eThe only comprehensive guide to the history and science of Alzheimer’s disease. \u003c\/b\u003eThis book will help you understand how the disease was discovered, why it is affecting our memory, what actually happens in the brain and how we can reduce our risk for Alzheimer’s disease.\u003cbr\u003e \u003cbr\u003eWith vivid examples, Professor Michael Hornberger takes you on a whistle-stop tour of every aspect of the most common form of dementia, from its origins to modern diagnosis and treatment.\u003cbr\u003e \u003cbr\u003eYou can discover scientifically proven Alzheimer’s disease prevention strategies and lifestyle changes.\u003cbr\u003e \u003cbr\u003eYou can understand why people with the disease are often ‘living in the last’ and get disoriented as to where they are.\u003cbr\u003e \u003cbr\u003eAnd you can learn more about the rare forms of Alzheimer’s disease that are often mistaken for other conditions.\u003cbr\u003e \u003cbr\u003eWritten for the general public, this book deals with:\u003cbr\u003e \u003cul\u003e \u003cli\u003eWhat causes Alzheimer’s disease?\u003c\/li\u003e \u003cli\u003eWhy Alzheimer’s often affects our memory first\u003c\/li\u003e \u003cli\u003eThe role of genetics in raising and lowering risk for the disease\u003c\/li\u003e \u003cli\u003eWhat new treatments are emerging\u003c\/li\u003e \u003cli\u003eThe chances you will inherit Alzheimer’s from your parents\u003c\/li\u003e \u003cli\u003eThe practical steps you can take to reduce your future risk for Alzheimer’s disease\u003c\/li\u003e \u003c\/ul\u003e \u003cbr\u003eOne in 14 people over 65 will get dementia and Alzheimer’s disease accounts for around 70% of all people with dementia.\u003cbr\u003e \u003cbr\u003eProfessor Michael Hornberger, a neuroscientist who has been researching people with Alzheimer’s for decades, has the key answers to help you and your family to understand the disease and reduce your risk for Alzheimer’s disease.\u003cbr\u003e \u003cbr\u003eHe starts by looking at the very first patient who was diagnosed with ‘Alzheimer’s’ disease - Auguste Deter. A German doctor, Alois Alzheimer, not only described her symptoms in meticulous detail but also reported after her death specific changes which are now the hallmark features of Alzheimer’s disease - so called tangles.\u003cbr\u003e \u003cbr\u003e\u003ci\u003eTangled Up \u003c\/i\u003erecounts Alzheimer’s intriguing interviews with Auguste Deter and the subsequent discovery of what was happening in the newly-named Alzheimer’s disease.\u003cbr\u003e \u003cbr\u003eIn essence, Alzheimer’s disease emerges when two proteins, amyloid and tau, build up in our brains. Once the proteins start accumulating, they start becoming toxic to the nerve cells which eventually start dying. The loss of those nerve cells affect people’s memory and spatial orientation in the early stages of the disease, since those memory regions seem to be most vulnerable to the accumulation of the proteins. It can cause people with the disease to be ‘living in the past’, as their old memories remain intact while newer memories are increasingly difficult to create. However, the disease has many variants and Professor Hornberger goes into the symptoms of lesser-known ones, such as Posterior Cortical Atrophy, which do not affect memory early on.\u003cbr\u003e \u003cbr\u003eHe also explains the role that inherited genes play in transmitting the disease, including the difference between risk genes, which only increase or decrease our risk, and familial Alzheimer’s disease genes, which make the development of the disease a near certainty.\u003cbr\u003e \u003cbr\u003eFinally, the book looks at new ‘biomarkers’ and blood tests to detect, diagnose and monitor Alzheimer’s, and which new medications are emerging to treat the disease.\u003cbr\u003e \u003cbr\u003eIn the absence of a cure, prevention becomes ever more important. Making modest lifestyle changes can make a big difference and the book gives realistic tips on looking after your heart, blood sugar and body mass. While other popularly touted techniques, Professor Hornberger explains, may not be worth your time or money.\u003cbr\u003e \u003cbr\u003e\u003cb\u003eAbout the author\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003eMichael Hornberger is Professor of Applied Dementia Research at Norwich Medical School at the University of East Anglia in the UK.\u003cbr\u003e \u003cbr\u003eHe regularly meets patients with Alzheimer’s disease as part of his research aimed at improving diagnosis, disease tracking and symptom management. \u003cbr\u003e \u003cbr\u003eMichael is originally from Germany and studied at the universities of Osnabruck and Vienna. He gravitated to England where he did his PhD at University College London before working at Cambridge University. He spent six years in Sydney, Australia, before returning to Cambridge. He finally arrived at UEA in November 2015. \u003cbr\u003e \u003cbr\u003e\u003cb\u003eIntroduction\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003eThis is not a book about dementia. This is a book about Alzheimer’s disease.\u003cbr\u003e \u003cbr\u003e\u003cb\u003e\u003ci\u003eWhat’s the difference, you might ask?\u003c\/i\u003e\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003eThe difference is that dementia is an umbrella term for all types of dementia, with Alzheimer’s disease being the most common form.\u003cbr\u003e \u003cbr\u003e\u003cb\u003e\u003ci\u003eWhy would one need a book on Alzheimer’s disease and not a book on dementia?\u003c\/i\u003e\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003eThere are already many excellent books on dementia available. However, to my knowledge there is none on the science behind Alzheimer’s disease specifically.\u003cbr\u003e \u003cbr\u003e\u003cb\u003e\u003ci\u003eWhy does it matter?\u003c\/i\u003e\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003eIf we want to understand the science behind dementia, we need to look at each type of dementia specifically, as the science for each type of dementia is quite different. We need to understand how a particular type of dementia develops in the brain, what changes it causes in the brain and how this results in the symptoms we see for this type of dementia. In essence, what is the science behind each type of dementia? \u003cbr\u003e \u003cbr\u003e\u003cb\u003e\u003ci\u003eWhat is this book about?\u003c\/i\u003e\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003eThis book focuses on the science (and history) of Alzheimer’s disease. Specifically, we will explore in detail how the brain changes in Alzheimer’s disease cause the symptoms of the disease and how new, upcoming treatments will deal with these brain changes. We will also explore the risk factors for Alzheimer’s disease and how we can potentially reduce them. We will start by travelling back in history to find out how Alois Alzheimer and Oskar Fischer ‘discovered’ the disease. \u003cbr\u003e \u003cbr\u003e\u003cb\u003e\u003ci\u003eWho is this book for?\u003c\/i\u003e\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003eFor everyone, and I mean everyone, who is interested in the science behind Alzheimer’s disease. No prior scientific knowledge should be required to understand the book, as I have gone to great lengths to explain the scientific concepts behind each important aspect. So, if you are an interested lay person, a person with dementia, a paid or unpaid carer, a family member, a dementia advocate, a healthcare professional or even a clinician, this book is for you. However, although this book will cover the basic science behind Alzheimer’s disease, it will not go into the science of dementia care, for which there are already some excellent books available by lay and professional carers. But if you are curious about how the changes in the brain cause the disease and its consequent symptoms and how we can potentially prevent them, then this book is for you.\u003cbr\u003e \u003cbr\u003e\u003cb\u003e\u003ci\u003eWhy this book now?\u003c\/i\u003e\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003eCommunication of science has been a passion of mine for nearly two decades. The reason I became interested was that I noticed how little scientific information was out there to provide people with detailed, but understandable scientific information on Alzheimer’s disease. What I found instead was a choice between either very generic scientific information, of the sort provided by websites, such as ‘it causes changes in the brain affecting your memory’; or scientific publications filled to the brim with jargon and acronyms, making it impossible for lay people to understand what these articles were discussing. \u003cbr\u003e \u003cbr\u003eI think there is a compromise between these two extremes, which allows a general reader to get a more detailed understanding of the science behind Alzheimer’s disease. Of course, I am not the first to think of that. Most dementia charities and organisations already provide such lay-friendly dementia science information. However, I could not find a book which compiled all the information in one place. So, I decided to write my own.\u003cbr\u003e \u003cbr\u003e\u003cb\u003eBuy the book and carry on reading!\u003c\/b\u003e","brand":"Canbury Press","offers":[{"title":"Default Title","offer_id":51020835160407,"sku":"9781914487422","price":22.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781914487422.jpg?v=1750784526","url":"https:\/\/bookcurl.com\/products\/tangled-up-9781914487422","provider":"Book Curl","version":"1.0","type":"link"}