{"product_id":"synthetic-methods-for-biologically-active-molecules-exploring-the-potential-of-bioreductions-9783527333875","title":"Synthetic Methods for Biologically Active Molecules: Exploring the Potential of Bioreductions","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis useful reference focuses on the currently available toolbox of bio-catalysed reductions of C=O, C=C and formal C=N bonds to show which transformations can be reliably used in manufacturing processes and which still require improvements. \u003cbr\u003e \u003cbr\u003e Following an introductory chapter, chapters 2-4 present the synthetic strategies that are currently available for the reduction of C=C and C=O bonds and for reductive amination, by means of whole-cell catalysts and isolated enzymes. Chapters 5-7 go on to describe the improvements achieved thus far, illustrating the current versatility of enzymes in organic synthesis. Chapters 8-12 present the improvements brought about by the optimization of reaction conditions, and the use of particular synthetic sequences. The final chapter describes practical applications of bio-reductions for the synthesis of active pharmaceutical ingredients. \u003cbr\u003e \u003cbr\u003e With its excellent and comprehensive overview, this book will be of great interest to those working in academia and industry.\u003cbr\u003e \u003cbr\u003e \u003cbr\u003e From the contents:\u003cbr\u003e * Development of Sustainable Biocatalyzed Reduction Processes for Organic Chemists\u003cbr\u003e * Reductases: From Natural Diversity to Biocatalysis and Emerging Enzymatic Activities.\u003cbr\u003e * Synthetic Strategies Based on C=C Bioreductions\u003cbr\u003e * Synthetic Strategies Based on C=O Bioreductions\u003cbr\u003e * Development of Novel Enzymes for the Improved Reduction of C=C Double Bonds\u003cbr\u003e * Development of Novel Enzymes for the Improved Reduction of C=O Double Bonds\u003cbr\u003e * Synthetic Applications of Aminotransferases\u003cbr\u003e * Strategies for Cofactor Regeneration in Biocatalyzed Reductions\u003cbr\u003e * Effects of Solvent System and Substrate Loading in Bioreduction\u003cbr\u003e * Perspectives in the Use of In-Situ Product Removal (ISPR) Techniques in Bioreductions\u003cbr\u003e * Multi-Enzymatic Cascade Reactions Based on Reduction Processes\u003cbr\u003e * Relevant Practical Applications of Bioreduction Processes in the Synthesis of Active Pharmaceutical Ingredients\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface\u003cbr\u003e \u003cbr\u003e DEVELOPMENT OF SUSTAINABLE BIOCATALYTIC REDUCTION PROCESSES FOR ORGANIC CHEMISTS\u003cbr\u003e Introduction\u003cbr\u003e Biocatalytic Reductions of C=O Double Bonds\u003cbr\u003e Biocatalytic Reductions of C=C Double Bonds\u003cbr\u003e Biocatalytic Reductions of Imines to Amines\u003cbr\u003e Biocatalytic Reductions of Nitriles to Amines\u003cbr\u003e Biocatalytic Deoxygenation Reactions\u003cbr\u003e Emerging Reductive Biocatalytic Reactions\u003cbr\u003e Reaction Engineering for Biocatalytic Reduction Processes\u003cbr\u003e Summary and Outlook\u003cbr\u003e \u003cbr\u003e REDUCTASES: FROM NATURAL DIVERSITY TO ESTABLISHED BIOCATALYSIS AND TO EMERGING ENZYMATIC ACTIVITIES\u003cbr\u003e Reductases: Natural Occurrence and Context for Biocatalysis\u003cbr\u003e Emerging Cases of Reductases in Biocatalysis\u003cbr\u003e Concluding Remarks\u003cbr\u003e \u003cbr\u003e SYNTHETIC STRATEGIES BASED ON C=C BIOREDUCTIONS FOR THE PREPARATION OF BIOLOGICALLY ACTIVE MOLECULES\u003cbr\u003e Introduction\u003cbr\u003e Bioreduction of Alpha,Beta-Unsaturated Carbonyl Compounds\u003cbr\u003e Bioreduction of Nitroolefins\u003cbr\u003e Bioreduction of Alpha,Beta-Unsaturated Carboxylic Acids and Derivatives\u003cbr\u003e Bioreduction of Alpha,Beta-Unsaturated Nitriles\u003cbr\u003e Concluding Remarks\u003cbr\u003e \u003cbr\u003e SYNTHETIC STRATEGIES BASED ON C=O BIOREDUCTIONS FOR THE PREPARATION OF BIOLOGICALLY ACTIVE MOLECULES\u003cbr\u003e Introduction\u003cbr\u003e Synthesis of Biologically Active Compounds through C=O Bioreduction\u003cbr\u003e Other Strategies to Construct Biologically Active Compounds\u003cbr\u003e Summary and Outlook\u003cbr\u003e \u003cbr\u003e PROTEIN ENGINEERING: DEVELOPMENT OF NOVEL ENZYMES FOR THE IMPROVED REDUCTION OF C=C DOUBLE BONDS\u003cbr\u003e Introduction\u003cbr\u003e The Protein Engineering Process and Employed Mutagenesis Methods\u003cbr\u003e Examples of Rational Design of Old Yellow Enzymes\u003cbr\u003e Evolving Old Yellow Enzymes (OYEs)\u003cbr\u003e Conclusions and Perspectives\u003cbr\u003e \u003cbr\u003e PROTEIN ENGINEERING: DEVELOPMENT OF NOVEL ENZYMES FOR THE IMPROVED REDUCTION OF C=O DOUBLE BONDS\u003cbr\u003e Introduction\u003cbr\u003e Detailed Characterization of PAR\u003cbr\u003e Detailed Characterization of LSADH\u003cbr\u003e Engineering of PAR for Increasing Activity in 2-Propanol\/Water Medium\u003cbr\u003e Application of Whole-Cell Biocatalysts Possessing Mutant PARs and LSADH\u003cbr\u003e Engineering of Beta-Keto Ester Reductase (KER) for Raising Thermal Stability and Stereoselectivity\u003cbr\u003e New Approach for Engineering or Obtaining Useful ADHs\/Reductases\u003cbr\u003e \u003cbr\u003e SYNTHETIC APPLICATIONS OF AMINOTRANSFERASES FOR THE PREPARATION OF BIOLOGICALLY ACTIVE MOLECULES\u003cbr\u003e Introduction\u003cbr\u003e Applications\u003cbr\u003e Challenges\u003cbr\u003e Future Research Needs\u003cbr\u003e Conclusions\u003cbr\u003e \u003cbr\u003e STRATEGIES FOR COFACTOR REGENERATION IN BIOCATALYZED REDUCTIONS\u003cbr\u003e Introduction: NAD(P)H as the Universal Reductant in Reduction Biocatalysis\u003cbr\u003e The Most Relevant Cofactor Regeneration Approaches - and How to Choose the Most Suitable One\u003cbr\u003e Coupling the Reduction Reaction to a Regeneration Reaction Producing a Valuable Compound\u003cbr\u003e Avoiding NAD(P)H: Does it Also Mean Avoiding the Challenge?\u003cbr\u003e Conclusions\u003cbr\u003e \u003cbr\u003e SOLVENT EFFECTS IN BIOREDUCTIONS\u003cbr\u003e Introduction\u003cbr\u003e Solvent Systems for Biocatalytic Reductions\u003cbr\u003e Solvent Control of Enzyme Selectivity\u003cbr\u003e Concluding Remarks\u003cbr\u003e \u003cbr\u003e APPLICATION OF IN SITU PRODUCT REMOVAL (ISPR) TECHNOLOGIES FOR IMPLEMENTATION AND SCALE-UP OF BIOCATALYTIC REDUCTIONS\u003cbr\u003e Introduction\u003cbr\u003e Process Requirements for Scale-Up\u003cbr\u003e Bioreduction Process Engineering\u003cbr\u003e In situ Product Removal\u003cbr\u003e Biocatalyst Format\u003cbr\u003e Selected Examples\u003cbr\u003e Future Outlook\u003cbr\u003e Conclusions\u003cbr\u003e \u003cbr\u003e BIOREDUCTIONS IN MULTIENZYMATIC ONE-POT AND CASCADE PROCESSES\u003cbr\u003e Introduction\u003cbr\u003e Coupled Oxidation and Reduction Reactions\u003cbr\u003e Consecutive and Cascade One-Pot Reductions\u003cbr\u003e Cascade Processes, Including Biocatalyzed Reductive Amination Steps\u003cbr\u003e Other Examples of Multienzymatic Cascade Processes, Including Bioreductive Reactions\u003cbr\u003e \u003cbr\u003e DYNAMIC KINETIC RESOLUTIONS BASED ON REDUCTION PROCESSES\u003cbr\u003e Introduction\u003cbr\u003e Cyclic Compounds\u003cbr\u003e Acyclic Alpha-Substituted-Beta-Keto Esters and 2-Substituted-1,3-Diketones\u003cbr\u003e Acyclic Ketones and Aldehydes\u003cbr\u003e Conclusions\u003cbr\u003e \u003cbr\u003e RELEVANT PRACTICAL APPLICATIONS OF BIOREDUCTION PROCESSES IN THE SYNTHESIS OF ACTIVE PHARMACEUTICAL INGREDIENT\u003cbr\u003e Introduction\u003cbr\u003e Ketoreductases\u003cbr\u003e Ene Reductases\u003cbr\u003e Others\u003cbr\u003e Bioreduction-Supported Processes\u003cbr\u003e Outlook\u003cbr\u003e \u003cbr\u003e Index\u003cbr\u003e","brand":"Wiley-VCH Verlag GmbH","offers":[{"title":"Default Title","offer_id":53196947456343,"sku":"9783527333875","price":135.85,"currency_code":"GBP","in_stock":false}],"url":"https:\/\/bookcurl.com\/products\/synthetic-methods-for-biologically-active-molecules-exploring-the-potential-of-bioreductions-9783527333875","provider":"Book Curl","version":"1.0","type":"link"}