{"product_id":"symmorphosis-on-form-and-function-in-shaping-life-john-m-prather-lectures-9780674000681","title":"Symmorphosis On Form and Function in Shaping Life","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eAre animals designed economically? The theory of symmorphosis predicts that the size of the parts in a system must be matched to the overall functional demand. Weibel shows how animals as different as shrews, pronghorns, dogs, goatsâeven humansâall develop from essentially the same blueprint by variation of design.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSymmorphosis\u003c\/i\u003e is (and I use the term advisedly) magisterial: the best description anywhere of a provocative and creatively stimulating research approach to a large number of very important basic questions in animal--more specifically mammalian and human--anatomy, physiology, and evolution. This book is synthetic in the best sense of that word. -- Malcolm S. Gordon, University of California, Los Angeles\u003cbr\u003eWeibel's treatment serves as an excellent introduction to mammalian respiratory and exercise physiology. His writing is as concise and linearly organized as the pathway for oxygen that he so eloquently describes…Weibel has done an admirable job of describing both morphology and functional performance. -- Robert Dudley * American Scientist *\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface    Form and Function   The Relation of Form and Function   Adaptation of Function as a Design Principle   Integration of Function as a Design Principle   Economy as a Design Principle   The Principle of Symmorphosis    Cells and Tissues: Oxidative Metabolism in Muscle   Energy Supply and Mitochondria   Is Mitochondrial Structure Matched to the Demand for Oxidative Energy?   Testing for a Quantitative Match of Form and Function in Muscle Mitochondria   Is 6VO2 Related to V(mi) in Exercising Muscle Cells?   Natural Variation in Energy Demand and Mitochondria   Are Muscle Capillaries Adjusted to Mitochondrial Oxygen Needs?   Symmorphosis in the O2 Pathway in Muscle    Muscle: Supplying Fuel and Oxygen to Mitochondria   Differences between Oxygen and Fuel Supply   Variations in Fuel Supply to Mitochondria in Working Muscle Cells   Partitioning of Fuel Consumption between Glucose and Fatty Acids   Estimating the Capillary Supply of Substrates   Revising the Model for Capillary Oxygen and Substrate Supply   Fuel Supply from Capillaries versus Intracellular Stores   Conclusions on Form and Function in Muscle Cells and Tissue    Organ Design: Building the Lung as a Gas Exchanger   Modeling Gas Exchange in the Lung   A Large Surface and a Thin Barrier Determine the Gas Exchange Capacity of the Lung   The Diffusing Capacity of the Human Lung   How Much Lung Diffusing Capacity Do We Really Need?   The Gas Exchanger of the Most Athletic Animal   The Effect of Reducing the Gas Exchanger   Conclusion    Problems with Lung Design: Keeping the Surface Large and the Barrier Thin   A Fiber Continuum Supports Parenchymal Structures   Controlled Surface Tension Determines Parenchymal Mechanics   Keeping the Barrier Dry and Thin   Conclusion    Airways and Blood Vessels: Ventilating and Perfusing a Large Surface   Morphogenesis of Airways, Vessels, and Gas Exchanger   Designing the Airway Tree for Efficient Ventilation   Are Airways Designed as Fractal Trees?   Conclusion    The Pathway for Oxygen: From Lung to Mitochondria   Testing the Hypothesis of Symmorphosis   The Strategy: Exploiting Comparative Physiology   The Model and Predictions   Testing the Respiratory System for Symmorphosis   Does Symmorphosis Prevail in the Respiratory System?    Adding Complexity in Form and Function: The Combined Pathways for Oxygen and Fuels   Strategies for Oxygen and Fuel Supply   Design of the Fuel Supply Pathway   Design of Nutrient Uptake Systems   The Substrate Pathways for Fueling Muscle Work   The Test of Symmorphosis   On Symmorphosis in Complex Pathways    Symmorphosis in Form and Function: Concepts, Facts, and Open Questions   How to Perform a Test of Symmorphosis: Future Prospects   Conclusions    References and Further Reading   Index","brand":"Harvard University Press","offers":[{"title":"Default Title","offer_id":51359085658455,"sku":"9780674000681","price":70.51,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780674000681.jpg?v=1754123521","url":"https:\/\/bookcurl.com\/products\/symmorphosis-on-form-and-function-in-shaping-life-john-m-prather-lectures-9780674000681","provider":"Book Curl","version":"1.0","type":"link"}