{"product_id":"structure-function-and-modulation-of-neuronal-voltagegated-ion-channels-9780471930136","title":"Structure Function and Modulation of Neuronal","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\"This volume provides a very straightforward overview of complex pharmaceutical industry processes and will certainly be beneficial to readers with diverse backgrounds; particularly for those who are not specialists in protein manufacturing, but have a need to understand the entire manufacturing and commercialization process.\" (\u003ci\u003eThe Quarterly Review of Biology\u003c\/i\u003e, June 2010)\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface.  \u003cp\u003eContributors.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 1 NEURONAL VOLTAGE-GATED ION CHANNEL FUNCTIONS.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Neuronal L-Type Voltage-Gated Calcium Channels (\u003ci\u003eAlexander Scriabine and David J. Triggle\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e2 Voltage-Gated N-Type and T-Type Calcium Channels and Excitability Disorders (\u003ci\u003eElizabeth Tringham and Terrance P. Snutch\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e3 Voltage-Gated Sodium Channels: Multiple Roles in the Pathophysiology of Pain (\u003ci\u003eSulayman D. Dib-Hajj, Bryan C. Hains, Joel A. Black,\u003c\/i\u003e and \u003ci\u003eStephen G. Waxman\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e4 The Role of Ion Channels in the Etiology and Development of Gliomas (\u003ci\u003eAmy K. Weaver and Harald Sontheimer\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e5 Shaker Family Kv1 Voltage-Gated Potassium Channels in Mammalian Brain Neurons (\u003ci\u003eHelene Vacher and James S. Trimmer\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e6 Unique Mitochondrial Ion Channels: Roles in Synaptic Transmission and Programmed Cell Death (\u003ci\u003eElizabeth A.\u003c\/i\u003e \u003ci\u003eJonas\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e7 Regulation of Neuronal Excitability by the Sodium-Activated Potassium Channels Slick (SLO2.1) and Slack (SLO2.2) (\u003ci\u003eValentin K. Gribkoff and Leonard K. Kaczmarek\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 2 MODULATORY MECHANISMS AND INFLUENCES ON NEURONAL VOLTAGE-GATED ION CHANNEL FUNCTION.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8 Alternative Splicing of Neuronal Cav2 Calcium Channels (\u003ci\u003eDiane Lipscombe, Summer E. Allen, Annette C. Gray, Spiro Marangoudakis, and Jesica Raingo\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e9 Effect of Hypoxia\/Ischemia on Voltage-Dependent Channels (\u003ci\u003eXiang Q. Gu, Hang Yao, and Gabriel G. Haddad\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e10 In Vivo Roles of Ion Channel Regulatory Protein Complexes in Neuronal Physiology and Behavior (\u003ci\u003eSmitha Reddy, Mohammad Shahidullah, and Irwin B. Levitan\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e11 Regulation of Neuronal Ion Channels by G-Protein-Coupled Receptors in Sympathetic Neurons (\u003ci\u003eMark S. Shapiro and Nikita Gamper\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e12 BK Channels: Regulation of Expression and Physiological Impact (\u003ci\u003eP. Kundu, A. Alioua, Y. Kumar, R. Lu, J. Ou, E. Sanchez-Pastor, M. Li, E. Stefani, and L. Toro\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e13 Structural Basis for Auxiliary KChIP Modulation of Kv4 Channels (\u003ci\u003eKeWei Wang and Jijie Chai\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 3 DRUG DISCOVERY TARGETS AND TECHNOLOGY.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14 Sodium Channel Blockers for the Treatment of Chronic Pain (\u003ci\u003eMark R. Bowlby and Edward Kaftan\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e15 Neuronal Kv7 Potassium Channels as Emerging Targets for the Treatment of Pain (\u003ci\u003eSteven I. Dworetzky and Valentin K. Gribkoff\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e16 Small-Molecule Modulators of Large-Conductance, Calcium-Activated (BK) Channels (\u003ci\u003eJohn E. Starrett Jr.\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e17 High-Throughput Screening Technologies in Ion Channel Drug Discovery (\u003ci\u003eEdward B. Stevens, Andrew D. Whyment, and J. Mark Treherne\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402685358423,"sku":"9780471930136","price":145.3,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780471930136.jpg?v=1730481228","url":"https:\/\/bookcurl.com\/products\/structure-function-and-modulation-of-neuronal-voltagegated-ion-channels-9780471930136","provider":"Book Curl","version":"1.0","type":"link"}