{"product_id":"structural-biology-in-drug-discovery-9781118681015","title":"Structural Biology in Drug Discovery","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eWith the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, \u003ci\u003eStructural Biology in Drug Discovery: Methods, Techniques, and Practices\u003c\/i\u003e describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field.\u003cbr\u003e\u003cbr\u003eThe combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that:\u003c\/p\u003e \u003cul\u003e \u003cli\u003ePresents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology\u003c\/li\u003e \u003cli\u003eIncludes detailed chapters on druggability, allostery, complementary use \u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"The book ... is a surprisingly comprehensive, monumental collection of chapters by a number of researchers in the field of drug discovery. ... [Editor Jean-Paul] Renaud was able to see the broad crucial aspects of the field and therefore able to invite excellent scientists to coauthor this book and cover so many aspects and in so much depth.\" -- Crystallography Reviews, March 2022\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eList of Contributors\u003c\/p\u003e \u003cp\u003ePreface\u003c\/p\u003e \u003cp\u003eChapter 01: The Evolving Role of Structural Biology in Drug Discovery\u003c\/p\u003e \u003cp\u003eChapter 02: A Structural View on Druggability: Experimental and Computational Approaches\u003c\/p\u003e \u003cp\u003eChapter 03: Structural Chemogenomics: Profiling Protein–Ligand Interactions in Polypharmacological Space\u003c\/p\u003e \u003cp\u003eChapter 04: Fragment-Based Ligand Discovery\u003c\/p\u003e \u003cp\u003eChapter 05: Combining Structural, Thermodynamic and Kinetic Information to Drive Hit-to-Lead Progression\u003c\/p\u003e \u003cp\u003eChapter 06: Allostery as Structure-Encoded Collective Dynamics: Significance in Drug Design\u003c\/p\u003e \u003cp\u003eChapter 07: Biophysical Assessment of Target Protein Quality in Structure-Based Drug discovery\u003c\/p\u003e \u003cp\u003eChapter 08: An Industrial Perspective on Protein-Ligand Complex Crystallization\u003c\/p\u003e \u003cp\u003eChapter 09: Membrane Protein Crystallization\u003c\/p\u003e \u003cp\u003eChapter 10: High-throughput Macromolecular Crystallography in Drug Discovery: Evolving in the Midst of Revolutions\u003c\/p\u003e \u003cp\u003eChapter 11: Assessment of Crystallographic Structure Quality and Protein – Ligand Complex Structure Validation\u003c\/p\u003e \u003cp\u003eChapter 12: Complementary Information from Neutron Crystallography Studies\u003c\/p\u003e \u003cp\u003eChapter 13: Determination of Protein Structure and Dynamics by NMR: State of the Art and Application to the Characterization of Biotherapeutics\u003c\/p\u003e \u003cp\u003eChapter 14: NMR Studies of Protein – Small Molecule Interactions for Drug Discovery\u003c\/p\u003e \u003cp\u003eChapter 15: Computational Structural Biology for Drug Discovery: Power and Limitations\u003c\/p\u003e \u003cp\u003eChapter 16: The Role of Structural Biology in Kinase Inhibitors Drug Discovery Success\u003c\/p\u003e \u003cp\u003eChapter 17: Serine Proteinases from the Blood Coagulation Cascade\u003c\/p\u003e \u003cp\u003eChapter 18: Epigenetic Proteins as Emerging Drug Targets\u003c\/p\u003e \u003cp\u003eChapter 19: Impact of Recently Determined Crystallographic Structures of GPCRs on Drug Discovery\u003c\/p\u003e \u003cp\u003eChapter 20: Targeting Protein–Protein Interactions Perspective\u003c\/p\u003e \u003cp\u003eChapter 21: Mass Spectrometry-Based Strategies for Therapeutic Antibodies Extensive Characterization and Optimization (OptimAbs)\u003c\/p\u003e \u003cp\u003eChapter 22: Integrating Evolution of Drug Resistance into Drug Discovery: Lessons from the Viral Proteases of HIV-1 and HCV\u003c\/p\u003e \u003cp\u003eChapter 23: A Comprehensive Review on Mycobacterium Tuberculosis Targets and Drug Development from a Structural Perspective\u003c\/p\u003e \u003cp\u003eChapter 24: Using Crystal Structures of Drug-Metabolizing Enzymes in Mechanism-Based Modeling for Drug Design\u003c\/p\u003e \u003cp\u003eChapter 25: Intrinsically Disordered Proteins (IDPs): Targets for the Future?\u003c\/p\u003e \u003cp\u003eChapter 26: Cryo-electron Microscopy as a Tool for Drug Discovery in the Context of Integrative Structural Biology\u003c\/p\u003e \u003cp\u003eChapter 27: Application of Hard-X-ray Free-electron Lasers for Static and Dynamic Processes in Structural Biology\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49406904664407,"sku":"9781118681015","price":223.2,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118681015.jpg?v=1730497509","url":"https:\/\/bookcurl.com\/products\/structural-biology-in-drug-discovery-9781118681015","provider":"Book Curl","version":"1.0","type":"link"}