{"product_id":"structural-bioinformatics-9780470181058","title":"Structural Bioinformatics","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eStructural Bioinformatics\u003c\/i\u003e was the first major effort to show the application of the principles and basic knowledge of the larger field of bioinformatics to questions focusing on macromolecular structure, such as the prediction of protein structure and how proteins carry out cellular functions, and how the application of bioinformatics to these life science issues can improve healthcare by accelerating drug discovery and development. Designed primarily as a reference, the first edition nevertheless saw widespread use as a textbook in graduate and undergraduate university courses dealing with the theories and associated algorithms, resources, and tools used in the analysis, prediction, and theoretical underpinnings of DNA, RNA, and proteins.  \u003cp\u003eThis new edition contains not only thorough updates of the advances in structural bioinformatics since publication of the first edition, but also features eleven new chapters dealing with frontier areas of high scientific impact, including\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"Offering a detailed coverage for practitioners but remaining accessible to the novice, Structural Bioinformatics, Second Edition is a valuable and excellent textbook for readers in the bioinformatics and advanced biology fields, and on the best way to become a classic reference for all interested parties (educators, researchers and graduate students.)\" (Advances in Food Sciences, 2011)\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003eForeword xi\u003c\/p\u003e \u003cp\u003ePreface xv\u003c\/p\u003e \u003cp\u003eAcknowledgments xix\u003c\/p\u003e \u003cp\u003eContributors xxi\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection I Data Collection, Analysis, and Visualization 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Defining Bioinformatics and Structural Bioinformatics 3\u003cbr\u003e \u003ci\u003eRuss B. Altman and Jonathan M. Dugan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Fundamentals of Protein Structure 15\u003cbr\u003e \u003ci\u003eEric D. Scheeff and J. Lynn Fink\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Fundamentals of DNA and RNA Structure 41\u003cbr\u003e \u003ci\u003eStephen Neidle, Bohdan Schneider, and Helen M. Berman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Computational Aspects of High-throughput Crystallographic Macromolecular StructureDetermination 77\u003cbr\u003e \u003ci\u003ePaul D. Adams, Ralf W. Grosse-Kunstleve, and Axel T. Brunger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Macromolecular Structure Determination by NMR Spectroscopy 93\u003cbr\u003e \u003ci\u003eJohn L. Markley, Arash Bahrami, Hamid R. Eghbalnia, Francis C. Peterson, Robert C. Tyler, Eldon L. Ulrich,\u003c\/i\u003e \u003ci\u003eWilliam M. Westler, and Brian F. Volkman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Electron Microscopy in the Context of Structural Systems Biology 143\u003cbr\u003e \u003ci\u003eNiels Volkmann and Dorit Hanein\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Study of Protein Three-dimensional Structure and Dynamics Using Peptide Amide Hydrogen\/Deuterium Exchange Mass Spectrometry (DXMS) and Chemical Cross-linking with Mass Spectrometryto Constrain Molecular Modeling 171\u003cbr\u003e \u003ci\u003eSheng Li, Dmitri Mouradov, Gordon King, Tong Liu, Ian Ross, Bostjan Kobe, Virgil L. Woods Jr, and\u003c\/i\u003e \u003ci\u003eThomas Huber\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Search and Sampling in Structural Bioinformatics 207\u003cbr\u003e \u003ci\u003eIlan Samish\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Molecular Visualization 237\u003cbr\u003e \u003ci\u003eSteven Bottomley and Erik Helmerhorst\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection II Data Representation and Databases 269\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10 The PDB FORMAT, mmCIF Formats, and Other Data Formats 271\u003cbr\u003e \u003ci\u003eJohn D. Westbrook and Paula M.D. Fitzgerald\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 The Worldwide Protein Data Bank 293\u003cbr\u003e \u003ci\u003eHelen M. Berman, Kim Henrick, Haruki Nakamura, and John L. Markley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 The Nucleic Acid Database 305\u003cbr\u003e \u003ci\u003eBohdan Schneider, Joanna de la Cruz, Zukang Feng, Li Chen, Shuchismita Dutta, Irina Persikova, John D.\u003c\/i\u003e \u003ci\u003eWestbrook, Huanwang Yang, Jasmine Young, Christine Zardecki, and Helen M. Berman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Other Structure-based Databases 321\u003cbr\u003e \u003ci\u003eJ. Lynn Fink, Helge Weissig, and Philip E. Bourne\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection III Data Integrity and Comparative Features 339\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14 Structural Quality Assurance 341\u003cbr\u003e \u003ci\u003eRoman A. Laskowski\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 The Impact of Local Accuracy in Protein and RNA Structures: Validation as an Active Tool 377\u003cbr\u003e \u003ci\u003eJane S. Richardson and David C. Richardson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Structure Comparison and Alignment 397\u003cbr\u003e \u003ci\u003eMarc A. Marti-Renom, Emidio Capriotti, Ilya N. Shindyalov, and Philip E. Bourne\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Protein Structure Evolution and the SCOP Database 419\u003cbr\u003e \u003ci\u003eRaghu P. R. Metpally and Boojala V. B. Reddy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 the Cath Domain Structure Database 433\u003cbr\u003e \u003ci\u003eFrances M. G. Pearl, Alison Cuff, and Christine A. Orengo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection IV Structural and Functional Assignment 457\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e19 Secondary Structure Assignment 459\u003cbr\u003e \u003ci\u003eClaus A. Andersen and Burkhard Rost\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Identifying Structural Domains in Proteins 485\u003cbr\u003e \u003ci\u003eStella Veretnik, Jenny Gu, and Shoshana Wodak\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Inferring Protein Function From Structure 515\u003cbr\u003e \u003ci\u003eJames D. Watson, Gail J. Bartlett, and Janet M. Thornton\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Structural Annotation of Genomes 539\u003cbr\u003e \u003ci\u003eAdam J. Reid, Corin Yeats, Jonathan Lees, and Christine A. Orengo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 Evolution Studied Using Protein Structure 559\u003cbr\u003e \u003ci\u003eSong Yang, Ruben Valas, and Philip E. Bourne\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection V Macromolecular Interactions 573\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e24 Electrostatic Interactions 575\u003cbr\u003e \u003ci\u003eNathan A. Baker and J. Andrew McCammon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 Prediction of Protein–nucleic Acid Interactions 593\u003cbr\u003e \u003ci\u003eTimothy Robertson and Gabriele Varani\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 Prediction of Protein–protein Interactions From Evolutionary Information 615\u003cbr\u003e \u003ci\u003eAlfonso Valencia and Florencio Pazos\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27 Docking Methods, Ligand Design, and Validating Data Sets in the Structural Genomics Era 633\u003cbr\u003e \u003ci\u003eNatasja Brooijmans\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection VI Structure Prediction 663\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e28 CASP and other Community-wide Assessments to Advance the Field Of Structure Prediction 665\u003cbr\u003e \u003ci\u003eJenny Gu and Philip E. Bourne\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29 Prediction of Protein Structure in 1d: Secondary Structure, Membrane Regions, and SolventAccessibility 679\u003cbr\u003e \u003ci\u003eBurkhard Rost\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e30 Homology Modeling 715\u003cbr\u003e \u003ci\u003eHanka Venselaar, Elmar Krieger, and Gert Vriend\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e31 Fold Recognition Methods 733\u003cbr\u003e \u003ci\u003eAdam Godzik\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e32 De Novo Protein Structure Prediction: Methods and Application 755\u003cbr\u003e \u003ci\u003eKevin Drew, Dylan Chivian, and Richard Bonneau\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e33 Rna Structural Bioinformatics 791\u003cbr\u003e \u003ci\u003eMagdalena A. Jonikas, Alain Laederach, and Russ B. Altman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection VII Therapeutic Discovery 807\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e34 Structural Bioinformatics in Drug Discovery 809\u003cbr\u003e \u003ci\u003eWilliam R. Pitt, Alícia Perez Higueruelo, and Colin R. Groom\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e35 B-cell Epitope Prediction 847\u003cbr\u003e \u003ci\u003eJulia V. Ponomarenko and Marc H.V. van Regenmortel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection VIII Future Challenges 879\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e36 Methods to Classify and Predict the Structure of Membrane Proteins 881\u003cbr\u003e \u003ci\u003eMarialuisa Pellegrini-Calace and Janet M. Thornton\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e37 Protein Motion: Simulation 907\u003cbr\u003e \u003ci\u003eIlan Samish, Jenny Gu, and Michael L. Klein\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e38 The Significance and Impacts of Protein Disorder and Conformational Variants 937\u003cbr\u003e \u003ci\u003eJenny Gu and Vincent J. Hilser\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e39 Protein Designability and Engineering 961\u003cbr\u003e \u003ci\u003eNikolay V. Dokholyan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e40 Structural Genomics of Protein Superfamilies 983\u003cbr\u003e \u003ci\u003eStephen K. Burley, Steven C. Almo, Jeffrey B. Bonanno, Mark R. Chance, Spencer Emtage, Andras Fiser,\u003c\/i\u003e \u003ci\u003eAndrej Sali, J. Michael Sauder, and Subramanyam Swaminathan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 1019\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":51767548739927,"sku":"9780470181058","price":109.2,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470181058.jpg?v=1758713734","url":"https:\/\/bookcurl.com\/products\/structural-bioinformatics-9780470181058","provider":"Book Curl","version":"1.0","type":"link"}