{"product_id":"steroid-dimers-9780470746578","title":"Steroid Dimers","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eSteroid dimers are an important group of compounds produced by various marine organisms, and also synthesized in the laboratories. This group of compounds possesses various pharmacological and biological properties, and can also be used to create molecular umbrellas for drug delivery.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eSteroid Dimers: Chemistry and Applications in Drug Design and Delivery\u003c\/i\u003e provides an up-to-date overview on the chemistry and applications of steroid dimers of natural and synthetic origins. The book includes easy-to-follow synthetic protocols for various classes of important dimeric steroids, source details, valuable spectroscopic data and depiction of unique structural features of natural steroidal dimers, and the Structure-Activity-Relationships (SARs) of some pharmacologically active dimeric steroids. Topics covered include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eintroduction to steroid dimers\u003c\/li\u003e \u003cli\u003esynthesis and chemistry of noncyclic and cyclic steroid dimers\u003c\/li\u003e \u003cli\u003enaturally occurring steroid dimers  cep\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface ix  \u003cp\u003eList of Abbreviations xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Steroids and Steroid Dimers 1\u003c\/p\u003e \u003cp\u003e1.2 General Physical and Spectroscopic Properties of Steroid Dimers 2\u003c\/p\u003e \u003cp\u003e1.3 Chromatographic Behaviour of Steroid Dimers 5\u003c\/p\u003e \u003cp\u003e1.4 Applications of Steroid Dimers 6\u003c\/p\u003e \u003cp\u003eReferences 6\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Synthesis of Acyclic Steroid Dimers 7\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Dimers via Ring A–Ring A Connection 7\u003c\/p\u003e \u003cp\u003e2.1.1 Direct Connection 7\u003c\/p\u003e \u003cp\u003e2.1.2 Through Spacer Groups 21\u003c\/p\u003e \u003cp\u003e2.2 Dimers via Ring B–Ring B Connection 68\u003c\/p\u003e \u003cp\u003e2.2.1 Direct Connection 68\u003c\/p\u003e \u003cp\u003e2.2.2 Through Spacer Groups 74\u003c\/p\u003e \u003cp\u003e2.3 Dimers via Ring C–Ring C Connection 84\u003c\/p\u003e \u003cp\u003e2.3.1 Through Spacer Groups 84\u003c\/p\u003e \u003cp\u003e2.4 Dimers via Ring D–Ring D Connection 87\u003c\/p\u003e \u003cp\u003e2.4.1 Direct Connection 87\u003c\/p\u003e \u003cp\u003e2.4.2 Through Spacer Groups 89\u003c\/p\u003e \u003cp\u003e2.4.3 Through Side Chain and Spacer Groups 100\u003c\/p\u003e \u003cp\u003e2.5 Dimers via Ring A–Ring D Connection 151\u003c\/p\u003e \u003cp\u003e2.5.1 Direct Connection 151\u003c\/p\u003e \u003cp\u003e2.6 Dimers via Connection of C-19 169\u003c\/p\u003e \u003cp\u003e2.7 Molecular Umbrellas 170\u003c\/p\u003e \u003cp\u003e2.8 Miscellaneous 174\u003c\/p\u003e \u003cp\u003eReferences 182\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Synthesis of Cyclic Steroid Dimers 187\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 With Spacer Groups: Cholaphanes 187\u003c\/p\u003e \u003cp\u003e3.2 Without Spacer Groups: Cyclocholates 232\u003c\/p\u003e \u003cp\u003eReferences 238\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Naturally Occurring Steroid Dimers 241\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Cephalostatins 242\u003c\/p\u003e \u003cp\u003e4.2 Crellastatins 254\u003c\/p\u003e \u003cp\u003e4.3 Ritterazines 262\u003c\/p\u003e \u003cp\u003e4.4 Others 277\u003c\/p\u003e \u003cp\u003eReferences 284\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Synthesis of Cephalostatin and Ritterazine Analogues 287\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 287\u003c\/p\u003e \u003cp\u003e5.2 Synthesis of Cephalostatin and Ritterazine Analogues 288\u003c\/p\u003e \u003cp\u003e5.3 Total Synthesis of Naturally Occurring Cephalostatin 1 371\u003c\/p\u003e \u003cp\u003eReferences 376\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Applications of Steroid Dimers 379\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Application of Steroid Dimers as ‘Molecular Umbrellas’: Drug Delivery 379\u003c\/p\u003e \u003cp\u003e6.2 Biological and Pharmacological Functions of Steroid Dimers: Drug Discovery and Design 382\u003c\/p\u003e \u003cp\u003e6.2.1 Antimalarial Activity 383\u003c\/p\u003e \u003cp\u003e6.2.2 Cytotoxicity and Anticancer Potential 386\u003c\/p\u003e \u003cp\u003e6.2.3 Effect on Micellar Concentrations of Bile Salts and Serum Cholesterol Level 401\u003c\/p\u003e \u003cp\u003e6.2.4 Effect on Bilayer Lipid Membranes 402\u003c\/p\u003e \u003cp\u003e6.2.5 Supramolecular Transmembrane Ion Channels, and Artificial Receptors and Ionophores 402\u003c\/p\u003e \u003cp\u003e6.2.6 Other Properties 404\u003c\/p\u003e \u003cp\u003eReferences 405\u003c\/p\u003e \u003cp\u003eIndex 409\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402424525143,"sku":"9780470746578","price":128.2,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470746578.jpg?v=1730480358","url":"https:\/\/bookcurl.com\/products\/steroid-dimers-9780470746578","provider":"Book Curl","version":"1.0","type":"link"}