{"product_id":"statistical-design-monitoring-and-analysis-of-clinical-trials-9780367772444","title":"Statistical Design Monitoring and Analysis of","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eStatistical Design, Monitoring, and Analysis of Clinical Trials, Second Edition\u003c\/strong\u003e concentrates on the biostatistics component of clinical trials. This new edition is updated throughout and includes five new chapters.\u003c\/p\u003e\u003cp\u003eDeveloped from the authorsâ courses taught to public health and medical students, residents, and fellows during the past 20 years, the text shows how biostatistics in clinical trials is an integration of many fundamental scientific principles and statistical methods. The book begins with ethical and safety principles, core trial design concepts, the principles and methods of sample size and power calculation, and analysis of covariance and stratified analysis. It then focuses on sequential designs and methods for two-stage Phase II cancer trials to Phase III group sequential trials, covering monitoring safety, futility, and efficacy. The authors also discuss the development of sample size reestimation and adaptive group sequential procedures, phase \u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\"This book gives a good overview a bout various aspects of statistics in the design, monitoring and analysis of clinical trials and covers also modern topics. In my opinion this book can not only be helpful for teaching, but could also be a very helpful guidebook for inexperienced statistic ians as well as other researchers who are just starting to work in the field of clinical trials. It may also be a good tool to help the communication between multidisciplinary trial teams, as it covers the topics from several angles and does not purely foc us on statistics.\"\u003c\/p\u003e\u003cp\u003e- \u003cstrong\u003eStefanie Hayoz\u003c\/strong\u003e, ISCB News, September 2022.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e1. Overview. 2. Concepts and Methods of Statistical Designs. 3. Efficiency with Trade-Offs and Crossover Designs. 4. Sample Size and Power Calculations. 5. Analysis of Covariance and Stratified Analysis. 6. Regression Analysis of Survival Data 7. Sequential Designs and Methods—Part I: Expected Sample Size and Two-Stage Phase II Trials in Oncology 8. Sequential Designs and Methods—Part II: Monitoring Safety and Futility 9. Sequential Designs and Methods—Part III: Classical Group Sequential Trials 10. Monitoring the Maximum Information and Adaptive Sample-Size Designs 11. Multiplicity Issues and Methods for Controlling the Type-I Error Rate. 12.Clinical Trials with Predictive Biomarkers. 13. Seamless Phase II\/III: Select-the-Winner Design. 14. Statistical Significance and p-Values. 15. Estimand, Intercurrent Events, and Missing Data.\u003c\/p\u003e","brand":"CRC Press","offers":[{"title":"Default Title","offer_id":51018071081303,"sku":"9780367772444","price":999.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780367772444.jpg?v=1750775539","url":"https:\/\/bookcurl.com\/products\/statistical-design-monitoring-and-analysis-of-clinical-trials-9780367772444","provider":"Book Curl","version":"1.0","type":"link"}