{"product_id":"solidphase-organic-synthesis-9780470599143","title":"SolidPhase Organic Synthesis","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cb\u003ePresents both the fundamental concepts and the most recent applications in solid-phase organic synthesis\u003c\/b\u003e \u003cp\u003eWith its emphasis on basic concepts, \u003ci\u003eSolid-Phase Organic Synthesis\u003c\/i\u003e guides readers through all the steps needed to design and perform successful solid-phase organic syntheses. The authors focus on the fundamentals of heterogeneous supports in the synthesis of organic molecules, explaining the use of a solid material to facilitate organic synthesis. This comprehensive text not only presents the fundamentals, but also reviews the most recent research findings and applications, offering readers everything needed to conduct their own state-of-the-art science experiments.\u003c\/p\u003e \u003cp\u003eFeaturing chapters written by leading researchers in the field, \u003ci\u003eSolid-Phase Organic Synthesis\u003c\/i\u003e is divided into two parts:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003e\u003cb\u003ePart One\u003c\/b\u003e, Concepts and Strategies, discusses the linker groups used to attach the synthesis substrate to the solid support, colorimetric tests to \u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003ePreface xv\u003c\/p\u003e \u003cp\u003eAcknowledgments xvii\u003c\/p\u003e \u003cp\u003eContributors xix\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I Concepts and Strategies 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Linker Strategies in Modern Solid-Phase Organic Synthesis 3\u003cbr\u003e\u003c\/b\u003e\u003ci\u003ePeter J. H. Scott\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 3\u003c\/p\u003e \u003cp\u003e1.2 Classical Linker Strategies 5\u003c\/p\u003e \u003cp\u003e1.3 Multifunctional Linker Strategies 28\u003c\/p\u003e \u003cp\u003e1.4 Conclusions 73\u003c\/p\u003e \u003cp\u003eReferences 73\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Colorimetric Test For Solid-Phase Organic Synthesis 83\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eYan Teng and Patrick H. Toy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 83\u003c\/p\u003e \u003cp\u003e2.2 Functional Group Tests 84\u003c\/p\u003e \u003cp\u003e2.3 Conclusions 92\u003c\/p\u003e \u003cp\u003eReferences 92\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Practical Aspects of Combinatorial Solid-Phase Synthesis 95\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJan Hlavac, Miroslav Soural, and Viktor Krchnak\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 95\u003c\/p\u003e \u003cp\u003e3.2 Strategies in Combinatorial Solid-Phase Synthesis 101\u003c\/p\u003e \u003cp\u003e3.3 Equipment and Instrumentation 112\u003c\/p\u003e \u003cp\u003e3.4 Characterization and Purification 118\u003c\/p\u003e \u003cp\u003e3.5 Conclusions 121\u003c\/p\u003e \u003cp\u003eAcknowledgments 121\u003c\/p\u003e \u003cp\u003eReferences 121\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Diversity-Oriented Synthesis 131\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eKieron M. G. O’Connell, Warren R. J. D Galloway, Brett M. Ibbeson, Albert Isidro-Llobet, Cornelius J.\u003c\/i\u003e \u003ci\u003eO’Connor, and David R. Spring\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 131\u003c\/p\u003e \u003cp\u003e4.2 Small Molecules and Biology 131\u003c\/p\u003e \u003cp\u003e4.3 Diversity-Oriented Synthesis, Target-Oriented Synthesis, and Combinatorial Chemistry 133\u003c\/p\u003e \u003cp\u003e4.4 Molecular Diversity 134\u003c\/p\u003e \u003cp\u003e4.5 Diversity-Oriented Synthesis on Solid Phase 137\u003c\/p\u003e \u003cp\u003e4.6 Diversity-Oriented Synthesis Around Privileged Scaffolds 146\u003c\/p\u003e \u003cp\u003e4.7 Diversity Linker Units in Solid-Phase Organic Synthesis 147\u003c\/p\u003e \u003cp\u003e4.8 Conclusions 148\u003c\/p\u003e \u003cp\u003eReferences 149\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Diversity-Oriented Synthesis of Privileged Heterocycles Using Divergent Strategy 151\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSeung Bum Park and Jonghoon Kim\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 151\u003c\/p\u003e \u003cp\u003e5.2 Divergent Synthesis of Natural Product-Like Polyheterocycles Using a Cyclic Iminium as a Single Key Intermediate 153\u003c\/p\u003e \u003cp\u003e5.3 Conclusions 168\u003c\/p\u003e \u003cp\u003eReferences 168\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Chemo- and Regioselectivity Enhancement in Solid-Supported Reactions 171\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDouglas D. Young and Alexander Deiters\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 171\u003c\/p\u003e \u003cp\u003e6.2 Transition Metal-Mediated Solid-Supported Reactions 172\u003c\/p\u003e \u003cp\u003e6.3 Non-transition Metal-Mediated Solid-Supported Reactions 186\u003c\/p\u003e \u003cp\u003e6.4 Traceless Cleavage 192\u003c\/p\u003e \u003cp\u003e6.5 Conclusions 201\u003c\/p\u003e \u003cp\u003eReferences 201\u003c\/p\u003e \u003cp\u003ePart II Applications 205\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Asymmetric Synthesis On Solid Support 207\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eBaburaj Baskar and Kamal Kumar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 207\u003c\/p\u003e \u003cp\u003e7.2 Asymmetric Chemical Transformations of Solid-Supported Substrates 208\u003c\/p\u003e \u003cp\u003e7.3 Asymmetric Transformations Using Resin-Bound Chiral Catalysts and Auxiliaries 219\u003c\/p\u003e \u003cp\u003e7.4 Conclusions 227\u003c\/p\u003e \u003cp\u003eReferences 227\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Recent Advances in Microwave-Assisted Solid-Phase Synthesis of Heterocycles 231\u003cbr\u003e\u003c\/b\u003e\u003ci\u003ePrasad Appukkuttan, Vaibhav, P. Mehta, and Erik Van der Eycken\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 231\u003c\/p\u003e \u003cp\u003e8.2 Fused 1,3-oxazin-6-ones 232\u003c\/p\u003e \u003cp\u003e8.3 Thiazolo[4,5-d]pyrimidine-5,7-diones 233\u003c\/p\u003e \u003cp\u003e8.4 Pyrazoles 234\u003c\/p\u003e \u003cp\u003e8.5 HSP70 Modulators 234\u003c\/p\u003e \u003cp\u003e8.6 Benzimidazo[2,1-b]quinazolin-12(5H)-ones 236\u003c\/p\u003e \u003cp\u003e8.7 Imidazoles 237\u003c\/p\u003e \u003cp\u003e8.8 1,4-Naphthoquinones 238\u003c\/p\u003e \u003cp\u003e8.9 Phthalocyanines 238\u003c\/p\u003e \u003cp\u003e8.10 1,2,3,4-Tetrahydroquinolines 242\u003c\/p\u003e \u003cp\u003e8.11 1,2,3-Triazoles 243\u003c\/p\u003e \u003cp\u003e8.12 2,8-Diaminopurines 244\u003c\/p\u003e \u003cp\u003e8.13 Imidazolidin-4-ones 245\u003c\/p\u003e \u003cp\u003e8.14 Indoles 247\u003c\/p\u003e \u003cp\u003e8.15 1,2,3,4-Tetrahydroquinolines Using a SmI2-Cleavable Linker 248\u003c\/p\u003e \u003cp\u003e8.16 Hydantoins 249\u003c\/p\u003e \u003cp\u003e8.17 Imatinib 250\u003c\/p\u003e \u003cp\u003e8.18 Isoindolines 252\u003c\/p\u003e \u003cp\u003e8.19 2-(Benzylthio)imidazo[1,2a]-pyrimidin-5-ones 253\u003c\/p\u003e \u003cp\u003e8.20 2-Aminobenzothiazoles 254\u003c\/p\u003e \u003cp\u003e8.21 Pyrimidines, Pyrazoles, and Isoxazoles 255\u003c\/p\u003e \u003cp\u003e8.22 Quinolin-2(1H)-ones and Coumarins 256\u003c\/p\u003e \u003cp\u003e8.23 Benzofurans 257\u003c\/p\u003e \u003cp\u003e8.24 i-Condensed Purines 258\u003c\/p\u003e \u003cp\u003e8.25 2(1H)-Pyrazinones 259\u003c\/p\u003e \u003cp\u003e8.26 Conclusions 260\u003c\/p\u003e \u003cp\u003eReferences 261\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Solid-Phase Synthesis of Heterocycles From Peptides and Amino Acids 269\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eZhi Li, Marc Giulianotti, Wenteng Chen, Richard A. Houghten, and Yongping Yu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 269\u003c\/p\u003e \u003cp\u003e9.2 Synthesis of Various Heterocycles 269\u003c\/p\u003e \u003cp\u003eReferences 316\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Generation of Drug-Like Five-Membered Heterocyclic Libraries Using Carbon Disulfide and Merrifield\u003c\/b\u003e \u003cb\u003eResin 319\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eYoung-Dae Gong and Taeho Lee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 319\u003c\/p\u003e \u003cp\u003e10.2 Solid-Phase Synthesis of Related Thiazole Compounds 320\u003c\/p\u003e \u003cp\u003e10.3 Solid-Phase Synthesis of Benzoxazoles 333\u003c\/p\u003e \u003cp\u003e10.4 Solid-Phase Synthesis of Related Pyrazole Compounds and 1,3,4-Triazoles via a Dithiocarbazate Linker 334\u003c\/p\u003e \u003cp\u003e10.5 Solid-Phase Synthesis of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles via Selective Cyclization 342\u003c\/p\u003e \u003cp\u003e10.6 Solid-Phase Synthesis of 1,2,4-Thiadiazoles 347\u003c\/p\u003e \u003cp\u003e10.7 Summary 350\u003c\/p\u003e \u003cp\u003eReferences 350\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Recent Advances in Solid-Phase 1,3-Dipolar Cycloaddition Reactions 355\u003cbr\u003e\u003c\/b\u003eKirsi Harju and Jari Yli-Kauhaluoma\u003c\/p\u003e \u003cp\u003e11.1 Introduction 355\u003c\/p\u003e \u003cp\u003e11.2 Solid-Phase Synthesis of Pyrrolidines, Pyrrolines, and Pyrroles 356\u003c\/p\u003e \u003cp\u003e11.3 Synthesis of Pyrazolines and Pyrazoles 361\u003c\/p\u003e \u003cp\u003e11.4 Solid-Phase Synthesis of Imidazoles, 1,2,4-Triazoles, and 1,2,3-Triazoles 364\u003c\/p\u003e \u003cp\u003e11.5 Solid-Phase Synthesis of Isoxazolidines, Isoxazolines, and Isoxazoles 369\u003c\/p\u003e \u003cp\u003e11.6 Conclusions 378\u003c\/p\u003e \u003cp\u003eReferences 378\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Sulfones in Solid-Phase Heterocycle Synthesis 383\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eChai Hoon Soh and Yulin Lam\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 383\u003c\/p\u003e \u003cp\u003e12.2 Linkers 384\u003c\/p\u003e \u003cp\u003e12.3 Conclusions 411\u003c\/p\u003e \u003cp\u003eReferences 411\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Solid-Phase Organic Radiosynthesis 415\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eRaphael Hoareau and Peter J. H. Scott\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 415\u003c\/p\u003e \u003cp\u003e13.2 Solid-Phase Organic Radiosynthesis with Fluorine-18 416\u003c\/p\u003e \u003cp\u003e13.3 Solid-Phase Organic Radiosynthesis with Carbon-11 421\u003c\/p\u003e \u003cp\u003e13.4 Solid-Phase Organic Radiosynthesis with Other Radioisotopes 422\u003c\/p\u003e \u003cp\u003e13.5 Conclusions 424\u003c\/p\u003e \u003cp\u003eReferences 424\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Solid-Phase Synthesis of Dyes and Their Application As Sensors and Bioimaging Probes\u003c\/b\u003e \u003cb\u003e427\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMarc Vendrell, Hyung-Ho Ha, Sung Chan Lee, and Young-Tae Chang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 427\u003c\/p\u003e \u003cp\u003e14.2 On-Bead Sensors 428\u003c\/p\u003e \u003cp\u003e14.3 Solid-Phase Approaches in Fluorescent Labeling 429\u003c\/p\u003e \u003cp\u003e14.4 Solid-Phase Derivatization of Fluorescent Scaffolds 430\u003c\/p\u003e \u003cp\u003e14.5 Diversity-Oriented Fluorescent Libraries 433\u003c\/p\u003e \u003cp\u003e14.6 Conclusions 437\u003c\/p\u003e \u003cp\u003e14.7 Acknowledgments 437\u003c\/p\u003e \u003cp\u003eReferences 437\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Dendritic Molecules On Solid Support: Solid-Phase Synthesis and Applications 441\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eKerem Goren and Moshe Portnoy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction 441\u003c\/p\u003e \u003cp\u003e15.2 Synthesis 442\u003c\/p\u003e \u003cp\u003e15.3 Applications of Dendronized Supports 464\u003c\/p\u003e \u003cp\u003e15.4 Conclusions 480\u003c\/p\u003e \u003cp\u003eReferences 482\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Oligosaccharide Synthesis On Solid, Soluble Polymer, and Tag Supports 489\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eKatsunori Tanaka and Koichi Fukase\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction 489\u003c\/p\u003e \u003cp\u003e16.2 Solid-Phase Methods for Synthesis of Oligosaccharides 490\u003c\/p\u003e \u003cp\u003e16.3 Polymer-Supported and Tag-Assisted Oligosaccharide Synthesis in Solution 516\u003c\/p\u003e \u003cp\u003e16.4 Conclusions 526\u003c\/p\u003e \u003cp\u003e16.5 Acknowledgments 527\u003c\/p\u003e \u003cp\u003eReferences 527\u003c\/p\u003e \u003cp\u003eIndex 531\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402374422871,"sku":"9780470599143","price":121.46,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470599143.jpg?v=1730480207","url":"https:\/\/bookcurl.com\/products\/solidphase-organic-synthesis-9780470599143","provider":"Book Curl","version":"1.0","type":"link"}