{"product_id":"sixmembered-transition-states-in-organic-synthesis-9780470178836","title":"SixMembered Transition States in Organic","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book furthers readers' understanding of the amazing features of six-membered transition states in stereoselective organic reactions. Comprehensive and logically organized, it covers reactions classified in four categories: [3,3]-sigmatropic rearrangements, aldol reactions, metal allylation reactions, and stereoselective reductions. There is a thorough discussion of each reaction category, along with computational studies that support a proposal of a six-membered state. The book assists professors, researchers, and students in proposing reasonable transition states for the description of newly discovered stereoselective reactions.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003eFifty years ago, Zimmerman and Traxler put forth an audacious suggestion that in a reaction they were studying six of the atoms were oriented in a ring as the two components approached each other. This was at a time when no one considered the detailed orientation of molecules during reactions. This Zimmerman-Traxler hypothesis is now known to be not only correct for their reaction, but in fact true in many other chemical processes. As such, the idea is one of the fundamental organizing principles of organic chemistry. Yang (Montana State Univ.) has provided a useful collection of all reactions currently understood to proceed in such fashion. These reactions are contained in 4 chapters: \"[3,3] - Sigmatrophic Rearrangements,\" \"Aldol Reactions,\" \"Metal Allylation Reactions,\" and \"Stereoselective Reductions.\" This small book should be useful for both synthetic chemists and those studying mechanisms, particularly stereochemistry, of organic reactions. \u003cb\u003eSumming Up\u003c\/b\u003e: Recommended. Upper-division undergraduate through professional collections. -- \u003ci\u003eA. Fry, Wesleyan University\u003c\/i\u003e (\u003ci\u003eCHOICE\u003c\/i\u003e, March 2009)  \u003cp\u003eIt is an interesting, well-written, and carefully researched book, full of useful details for practioners and students of organic chemistry. (\u003ci\u003eJournal of the American Chemical Association\u003c\/i\u003e, July 2, 2008)\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface.  \u003cp\u003eIntroduction.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 [3,3]-Sigmatropic Rearrangements.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGeneral Considerations.\u003c\/p\u003e \u003cp\u003eReactions.\u003c\/p\u003e \u003cp\u003e1.1 Claisen Rearrangement.\u003c\/p\u003e \u003cp\u003e1.2 Johnson–Claisen Rearrangement.\u003c\/p\u003e \u003cp\u003e1.3 Ireland–Claisen Rearrangement.\u003c\/p\u003e \u003cp\u003e1.4 Cope Rearrangement.\u003c\/p\u003e \u003cp\u003e1.5 Anionic Oxy-Cope Rearrangement.\u003c\/p\u003e \u003cp\u003e1.6 Aza-Cope–Mannich Reaction.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Aldol Reactions.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGeneral Considerations.\u003c\/p\u003e \u003cp\u003eReactions.\u003c\/p\u003e \u003cp\u003e2.1 Asymmetric Syn-Aldol Reaction.\u003c\/p\u003e \u003cp\u003e2.2 Asymmetric Anti-Aldol Reaction.\u003c\/p\u003e \u003cp\u003e2.3 Proline-Catalyzed Asymmetric Aldol Reaction.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Metal Allylation Reactions.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGeneral Considerations.\u003c\/p\u003e \u003cp\u003eReactions.\u003c\/p\u003e \u003cp\u003e3.1 Boron Allylation Reaction.\u003c\/p\u003e \u003cp\u003e3.2 Silicon Allylation Reaction.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Stereoselective Reductions.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGeneral Considerations.\u003c\/p\u003e \u003cp\u003eReactions.\u003c\/p\u003e \u003cp\u003e4.1 Diastereoselective Syn-Reduction of β-Hydroxy Ketones.\u003c\/p\u003e \u003cp\u003e4.2 Diastereoselective Anti-Reduction of β-Hydroxy Ketones.\u003c\/p\u003e \u003cp\u003e4.3 Asymmetric Reduction.\u003c\/p\u003e \u003cp\u003eList of Copyrighted Materials.\u003c\/p\u003e \u003cp\u003eAbbreviations.\u003c\/p\u003e \u003cp\u003eSubject Index.\u003c\/p\u003e \u003cp\u003eScheme Index of Natural Products.\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402300334423,"sku":"9780470178836","price":147.56,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470178836.jpg?v=1730479991","url":"https:\/\/bookcurl.com\/products\/sixmembered-transition-states-in-organic-synthesis-9780470178836","provider":"Book Curl","version":"1.0","type":"link"}