{"product_id":"proteins-9780471498940","title":"Proteins","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e* An accessible introduction to the principles of protein structure and function. * Beautifully illustrated throughout in full colour. * Includes end of chapter problems, references to further reading and a full glossary of terms. * Associated website including web-based tutorials, problems and additional content.  .\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"…an invaluable resource…students of biochemistry, chemistry, genetics, structural biology, as well as medical and dental students will greatly benefit from reading this text…\" (\u003ci\u003eAnnals of Biomedical Engineering\u003c\/i\u003e, December 2005)  \u003cp\u003e\"…a worthwhile investment for the beginning student or for the advanced scientist seeking a better grasp of protein chemistry…\" (\u003ci\u003eClinical Chemistry\u003c\/i\u003e, November 2005)\u003c\/p\u003e \u003cp\u003e\"An outstanding resource for introductory protein chemistry courses and a solid reference for those interested in proteins.\" (\u003ci\u003eCHOIC\u003c\/i\u003eE, November 2005)\u003c\/p\u003e \u003cp\u003e\" … the distillation of years of lecturing and undergraduate feedback.\" (\u003ci\u003eJournal of Biological Education, Spring 2006: Vol.40; 2)\u003c\/i\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 An Introduction to protein structure and function 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eA brief and very selective historical perspective 1\u003c\/p\u003e \u003cp\u003eThe biological diversity of proteins 5\u003c\/p\u003e \u003cp\u003eProteins and the sequencing of the human and other genomes 9\u003c\/p\u003e \u003cp\u003eWhy study proteins? 9\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Amino acids: the building blocks of proteins 13\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe 20 amino acids found in proteins 13\u003c\/p\u003e \u003cp\u003eThe acid–base properties of amino acids 14\u003c\/p\u003e \u003cp\u003eStereochemical representations of amino acids 15\u003c\/p\u003e \u003cp\u003ePeptide bonds 16\u003c\/p\u003e \u003cp\u003eThe chemical and physical properties of amino acids 23\u003c\/p\u003e \u003cp\u003eDetection, identification and quantification of amino acids and proteins 32\u003c\/p\u003e \u003cp\u003eStereoisomerism 34\u003c\/p\u003e \u003cp\u003eNon-standard amino acids 35\u003c\/p\u003e \u003cp\u003eSummary 36\u003c\/p\u003e \u003cp\u003eProblems 37\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 The three-dimensional structure of proteins 39\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePrimary structure or sequence 39\u003c\/p\u003e \u003cp\u003eSecondary structure 39\u003c\/p\u003e \u003cp\u003eTertiary structure 50\u003c\/p\u003e \u003cp\u003eQuaternary structure 62\u003c\/p\u003e \u003cp\u003eThe globin family and the role of quaternary structure in modulating activity 66\u003c\/p\u003e \u003cp\u003eImmunoglobulins 74\u003c\/p\u003e \u003cp\u003eCyclic proteins 81\u003c\/p\u003e \u003cp\u003eSummary 81\u003c\/p\u003e \u003cp\u003eProblems 83\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 The structure and function of fibrous proteins 85\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe amino acid composition and organization of fibrous proteins 85\u003c\/p\u003e \u003cp\u003eKeratins 86\u003c\/p\u003e \u003cp\u003eFibroin 92\u003c\/p\u003e \u003cp\u003eCollagen 92\u003c\/p\u003e \u003cp\u003eSummary 102\u003c\/p\u003e \u003cp\u003eProblems 103\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 The structure and function of membrane proteins 105\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe molecular organization of membranes 105\u003c\/p\u003e \u003cp\u003eMembrane protein topology and function seen through organization of the erythrocyte membrane 110\u003c\/p\u003e \u003cp\u003eBacteriorhodopsin and the discovery of seven transmembrane helices 114\u003c\/p\u003e \u003cp\u003eThe structure of the bacterial reaction centre 123\u003c\/p\u003e \u003cp\u003eOxygenic photosynthesis 126\u003c\/p\u003e \u003cp\u003ePhotosystem I 126\u003c\/p\u003e \u003cp\u003eMembrane proteins based on transmembrane β barrels 128\u003c\/p\u003e \u003cp\u003eRespiratory complexes 132\u003c\/p\u003e \u003cp\u003eComplex III, the ubiquinol-cytochrome c oxidoreductase 132\u003c\/p\u003e \u003cp\u003eComplex IV or cytochrome oxidase 138\u003c\/p\u003e \u003cp\u003eThe structure of ATP synthetase 144\u003c\/p\u003e \u003cp\u003eATPase family 152\u003c\/p\u003e \u003cp\u003eSummary 156\u003c\/p\u003e \u003cp\u003eProblems 159\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 The diversity of proteins 161\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePrebiotic synthesis and the origins of proteins 161\u003c\/p\u003e \u003cp\u003eEvolutionary divergence of organisms and its relationship to protein structure and function 163\u003c\/p\u003e \u003cp\u003eProtein sequence analysis 165\u003c\/p\u003e \u003cp\u003eProtein databases 180\u003c\/p\u003e \u003cp\u003eGene fusion and duplication 181\u003c\/p\u003e \u003cp\u003eSecondary structure prediction 181\u003c\/p\u003e \u003cp\u003eGenomics and proteomics 183\u003c\/p\u003e \u003cp\u003eSummary 187\u003c\/p\u003e \u003cp\u003eProblems 187\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Enzyme kinetics, structure, function, and catalysis 189\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eEnzyme nomenclature 191\u003c\/p\u003e \u003cp\u003eEnzyme co-factors 192\u003c\/p\u003e \u003cp\u003eChemical kinetics 192\u003c\/p\u003e \u003cp\u003eThe transition state and the action of enzymes 195\u003c\/p\u003e \u003cp\u003eThe kinetics of enzyme action 197\u003c\/p\u003e \u003cp\u003eCatalytic mechanisms 202\u003c\/p\u003e \u003cp\u003eEnzyme structure 209\u003c\/p\u003e \u003cp\u003eLysozyme 209\u003c\/p\u003e \u003cp\u003eThe serine proteases 212\u003c\/p\u003e \u003cp\u003eTriose phosphate isomerase 215\u003c\/p\u003e \u003cp\u003eTyrosyl tRNA synthetase 218\u003c\/p\u003e \u003cp\u003eEcoRI restriction endonuclease 221\u003c\/p\u003e \u003cp\u003eEnzyme inhibition and regulation 224\u003c\/p\u003e \u003cp\u003eIrreversible inhibition of enzyme activity 227\u003c\/p\u003e \u003cp\u003eAllosteric regulation 231\u003c\/p\u003e \u003cp\u003eCovalent modification 237\u003c\/p\u003e \u003cp\u003eIsoenzymes or isozymes 241\u003c\/p\u003e \u003cp\u003eSummary 242\u003c\/p\u003e \u003cp\u003eProblems 244\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Protein synthesis, processing and turnover 247\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eCell cycle 247\u003c\/p\u003e \u003cp\u003eThe structure of Cdk and its role in the cell cycle 250\u003c\/p\u003e \u003cp\u003eCdk–cyclin complex regulation 252\u003c\/p\u003e \u003cp\u003eDNA replication 253\u003c\/p\u003e \u003cp\u003eTranscription 254\u003c\/p\u003e \u003cp\u003eEukaryotic transcription factors: variation on a ‘basic’ theme 261\u003c\/p\u003e \u003cp\u003eThe spliceosome and its role in transcription 265\u003c\/p\u003e \u003cp\u003eTranslation 266\u003c\/p\u003e \u003cp\u003eTransfer RNA (tRNA) 267\u003c\/p\u003e \u003cp\u003eThe composition of prokaryotic and eukaryotic ribosomes 269\u003c\/p\u003e \u003cp\u003eA structural basis for protein synthesis 272\u003c\/p\u003e \u003cp\u003eAn outline of protein synthesis 273\u003c\/p\u003e \u003cp\u003eAntibiotics provide insight into protein synthesis 278\u003c\/p\u003e \u003cp\u003eAffinity labelling and RNA ‘footprinting’ 279\u003c\/p\u003e \u003cp\u003eStructural studies of the ribosome 279\u003c\/p\u003e \u003cp\u003ePost-translational modification of proteins 287\u003c\/p\u003e \u003cp\u003eProtein sorting or targeting 293\u003c\/p\u003e \u003cp\u003eThe nuclear pore assembly 302\u003c\/p\u003e \u003cp\u003eProtein turnover 303\u003c\/p\u003e \u003cp\u003eApoptosis 310\u003c\/p\u003e \u003cp\u003eSummary 310\u003c\/p\u003e \u003cp\u003eProblems 312\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Protein expression, purification and characterization 313\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe isolation and characterization of proteins 313\u003c\/p\u003e \u003cp\u003eRecombinant DNA technology and protein expression 313\u003c\/p\u003e \u003cp\u003ePurification of proteins 318\u003c\/p\u003e \u003cp\u003eCentrifugation 320\u003c\/p\u003e \u003cp\u003eSolubility and ‘salting out’ and ‘salting in’ 323\u003c\/p\u003e \u003cp\u003eChromatography 326\u003c\/p\u003e \u003cp\u003eDialysis and ultrafiltration 333\u003c\/p\u003e \u003cp\u003ePolyacrylamide gel electrophoresis 333\u003c\/p\u003e \u003cp\u003eMass spectrometry 340\u003c\/p\u003e \u003cp\u003eHow to purify a protein? 342\u003c\/p\u003e \u003cp\u003eSummary 344\u003c\/p\u003e \u003cp\u003eProblems 345\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Physical methods of determining the three-dimensional structure of proteins 347\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 347\u003c\/p\u003e \u003cp\u003eThe use of electromagnetic radiation 348\u003c\/p\u003e \u003cp\u003eX-ray crystallography 349\u003c\/p\u003e \u003cp\u003eNuclear magnetic resonance spectroscopy 360\u003c\/p\u003e \u003cp\u003eCryoelectron microscopy 375\u003c\/p\u003e \u003cp\u003eNeutron diffraction 379\u003c\/p\u003e \u003cp\u003eOptical spectroscopic techniques 379\u003c\/p\u003e \u003cp\u003eVibrational spectroscopy 387\u003c\/p\u003e \u003cp\u003eRaman spectroscopy 389\u003c\/p\u003e \u003cp\u003eESR and ENDOR 390\u003c\/p\u003e \u003cp\u003eSummary 392\u003c\/p\u003e \u003cp\u003eProblems 393\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Protein folding in vivo and in vitro 395\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 395\u003c\/p\u003e \u003cp\u003eFactors determining the protein fold 395\u003c\/p\u003e \u003cp\u003eFactors governing protein stability 403\u003c\/p\u003e \u003cp\u003eFolding problem and Levinthal’s paradox 403\u003c\/p\u003e \u003cp\u003eModels of protein folding 408\u003c\/p\u003e \u003cp\u003eAmide exchange and measurement of protein folding 411\u003c\/p\u003e \u003cp\u003eKinetic barriers to refolding 412\u003c\/p\u003e \u003cp\u003eIn vivo protein folding 415\u003c\/p\u003e \u003cp\u003eMembrane protein folding 422\u003c\/p\u003e \u003cp\u003eProtein misfolding and the disease state 426\u003c\/p\u003e \u003cp\u003eSummary 435\u003c\/p\u003e \u003cp\u003eProblems 437\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Protein structure and a molecular approach to medicine 439\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 439\u003c\/p\u003e \u003cp\u003eSickle cell anaemia 441\u003c\/p\u003e \u003cp\u003eViruses and their impact on health as seen through structure and function 442\u003c\/p\u003e \u003cp\u003eHIV and AIDS 443\u003c\/p\u003e \u003cp\u003eThe influenza virus 457\u003c\/p\u003e \u003cp\u003ep53 and its role in cancer 470\u003c\/p\u003e \u003cp\u003eEmphysema and α1-antitrypsin 475\u003c\/p\u003e \u003cp\u003eSummary 478\u003c\/p\u003e \u003cp\u003eProblems 479\u003c\/p\u003e \u003cp\u003eEpilogue 481\u003c\/p\u003e \u003cp\u003eGlossary 483\u003c\/p\u003e \u003cp\u003eAppendices 491\u003c\/p\u003e \u003cp\u003eBibliography 495\u003c\/p\u003e \u003cp\u003eReferences 499\u003c\/p\u003e \u003cp\u003eIndex 511\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49396193558871,"sku":"9780471498940","price":51.25,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780471498940.jpg?v=1730415053","url":"https:\/\/bookcurl.com\/products\/proteins-9780471498940","provider":"Book Curl","version":"1.0","type":"link"}