{"product_id":"protein-evolution-9781405151665","title":"Protein Evolution","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book provides an up-to-date summary of the principles of protein evolution and discusses both the methods available to analyze the evolutionary history of proteins as well as those for predicting their structure-function relationships. \u003cbr\u003e \u003cul\u003e \u003cli style=\"list-style:\" none\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eIncludes a significantly expanded chapter on genome evolution to cover genomes of model organisms sequenced since the completion of the first edition, and organelle genome evolution\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eRetains its reader-friendly, accessible style and organization\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eContains an updated glossary and new references, including a list of online reference sites\u003c\/li\u003e \u003c\/ul\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface to the first edition. \u003cp\u003ePreface to the second edition.\u003c\/p\u003e \u003cp\u003eAcknowledgments.\u003c\/p\u003e \u003cp\u003eIntroduction.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1. Protein-Coding Genes\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e1.1 Structure of protein-coding genes.\u003c\/p\u003e \u003cp\u003e1.2 Transcription.\u003c\/p\u003e \u003cp\u003e1.3 Translation.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003eUseful internet resources.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2. Protein Structure\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e2.1 The polypeptide backbone.\u003c\/p\u003e \u003cp\u003e2.2 The amino acids.\u003c\/p\u003e \u003cp\u003e2.3 Covalent modifications of amino acid side chains.\u003c\/p\u003e \u003cp\u003e2.4 Interactions that govern protein folding and stability.\u003c\/p\u003e \u003cp\u003e2.5 Secondary structural elements.\u003c\/p\u003e \u003cp\u003e2.6 Supersecondary structures.\u003c\/p\u003e \u003cp\u003e2.7 Tertiary structures of proteins.\u003c\/p\u003e \u003cp\u003e2.8 Multidomain proteins.\u003c\/p\u003e \u003cp\u003e2.9 Multisubunit proteins.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003eUseful internet resources.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3. Mutations\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e3.1 Types of mutations.\u003c\/p\u003e \u003cp\u003e3.2 Factors affecting rates of mutation.\u003c\/p\u003e \u003cp\u003e3.3 The fate of mutations.\u003c\/p\u003e \u003cp\u003e3.4 The molecular clock.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003eUseful internet resources.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4. Evolution of Protein-Coding Genes\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e4.1 Alignment of nucleotide and amino acid sequences.\u003c\/p\u003e \u003cp\u003e4.2 Estimating the number of nucleotide substitutions.\u003c\/p\u003e \u003cp\u003e4.3 Rates and patterns of nucleotide substitution.\u003c\/p\u003e \u003cp\u003e4.4 Variation in substitution rates.\u003c\/p\u003e \u003cp\u003e4.5 Molecular phylogeny.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003eUseful internet resources.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5. Evolution of Orthologous Proteins\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e5.1 Orthologous proteins with the same function in different species.\u003c\/p\u003e \u003cp\u003e5.2 Orthologous proteins with modified function in different species.\u003c\/p\u003e \u003cp\u003e5.3 Orthologous proteins with major modification of function.\u003c\/p\u003e \u003cp\u003e5.4 Orthologous proteins that have lost their function.\u003c\/p\u003e \u003cp\u003e5.5 Orthologous proteins that have gained additional functions.\u003c\/p\u003e \u003cp\u003e5.6 Prediction of the function of orthologous proteins.\u003c\/p\u003e \u003cp\u003e5.7 The three-dimensional structure of orthologous proteins.\u003c\/p\u003e \u003cp\u003e5.8 Detecting sequence homology of protein-coding genes.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003eUseful internet resources.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6. Formation of Novel Protein-Coding Genes\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e6.1 \u003ci\u003eDe novo\u003c\/i\u003e formation of novel protein-coding genes.\u003c\/p\u003e \u003cp\u003e6.2 Gene duplications.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003eUseful internet resources.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7. Evolution of Paralogous Proteins\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e7.1 Advantageous duplications.\u003c\/p\u003e \u003cp\u003e7.2 Neutral duplications.\u003c\/p\u003e \u003cp\u003e7.3 Similarities and differences in the evolution of paralogous and orthologous proteins.\u003c\/p\u003e \u003cp\u003e7.4 Predicting the function of proteins by homology.\u003c\/p\u003e \u003cp\u003e7.5 Detecting distant homology of protein-coding genes.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003eUseful internet resources.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8. Protein Evolution by Assembly from Modules\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e8.1 Modular assembly by intronic recombination.\u003c\/p\u003e \u003cp\u003e8.2 Modular assembly by exonic recombination.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003eUseful internet resources.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9. Genome Evolution and Protein Evolution\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e9.1 Evolution of genome size.\u003c\/p\u003e \u003cp\u003e9.2 The role and survival of nongenic DNA.\u003c\/p\u003e \u003cp\u003e9.3 Repetitiveness of genomic DNA.\u003c\/p\u003e \u003cp\u003e9.4 Mechanisms responsible for increases in genome size.\u003c\/p\u003e \u003cp\u003e9.5 Compositional organization of eukaryotic genomes.\u003c\/p\u003e \u003cp\u003e9.6 Genomes of model organisms.\u003c\/p\u003e \u003cp\u003e9.7 The genome of the cenancestor.\u003c\/p\u003e \u003cp\u003e9.8 Changes in gene number and gene density in different evolutionary lineages.\u003c\/p\u003e \u003cp\u003e9.9 Proteome evolution.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003eUseful internet resources.\u003c\/p\u003e \u003cp\u003eGlossary.\u003c\/p\u003e \u003cp\u003eIndex\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49529333252439,"sku":"9781405151665","price":75.95,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781405151665.jpg?v=1731875208","url":"https:\/\/bookcurl.com\/products\/protein-evolution-9781405151665","provider":"Book Curl","version":"1.0","type":"link"}