{"product_id":"protein-carbonylation-9781119074915","title":"Protein Carbonylation","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eProtein carbonylation has attracted the interest of a great number of laboratories since the pioneering studies at the Earl Stadtman's lab at NIH started in early 1980s. Since then, detecting protein carbonyls in oxidative stress situations became a highly efficient tool to uncover biomarkers of oxidative damage in normal and altered cell physiology.\u003c\/p\u003e \u003cp\u003eIn this book, research groups from several areas of interest have contributed to update the knowledge regarding detection, analyses and identification of carbonylated proteins and the sites where these modifications occur.\u003c\/p\u003e \u003cp\u003eThe scientific community will benefit from these reviews since they deal with specific, detailed technical approaches to study formation and detection of protein carbonyls. Moreover, the biological impact of such modifications in metabolic, physiologic and structural functions and, how these alterations can help understanding the downstream effects on cell function are discussed.\u003c\/p\u003e \u003cul\u003e \u003cli\u003eOxidative s\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eList of Contributors xii\u003c\/p\u003e \u003cp\u003ePreface xvi\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Reactive Oxygen Species Signaling from the Perspective of the Stem Cell 1\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSaghi Ghaffari and Raymond Liang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.2 ROS Regulation 2\u003c\/p\u003e \u003cp\u003e1.3 ROS Signaling 3\u003c\/p\u003e \u003cp\u003e1.4 ROS and Stem Cells 5\u003c\/p\u003e \u003cp\u003e1.5 ROS, Metabolism, and Epigenetic Influence 9\u003c\/p\u003e \u003cp\u003e1.6 Stem Cells and Mitochondria 9\u003c\/p\u003e \u003cp\u003e1.7 ROS and Stem Cell Aging 12\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Analysis of Protein Carbonylation 24\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAshraf G. Madian, Fred E. Regnier, and Ao Zeng\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 24\u003c\/p\u003e \u003cp\u003e2.2 In Vivo Carbonylation Reactions 27\u003c\/p\u003e \u003cp\u003e2.3 Analytical Derivatization of Carbonylated Groups 34\u003c\/p\u003e \u003cp\u003e2.4 Selective Purification and\/or Detection of Carbonylated Proteins and Peptides 36\u003c\/p\u003e \u003cp\u003e2.5 Oxidative Stress]Based PTMS Not Involving Carbonylation 38\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Diversity of Protein Carbonylation Pathways: Direct Oxidation,Glycoxidation, and Modifications by Lipid Peroxidation Products 48\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMaria Fedorova\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 48\u003c\/p\u003e \u003cp\u003e3.2 Pathways of Protein Carbonylation 49\u003c\/p\u003e \u003cp\u003e3.3 Analytical Methods for Detection of Total and Specific Protein Carbonylation 57\u003c\/p\u003e \u003cp\u003e3.4 Protein Susceptibility to Different Carbonylation Pathways and Modifications Cross]Talk 67\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Protein Carbonylation by Reactive Lipids 83\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eKoji Uchida\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 83\u003c\/p\u003e \u003cp\u003e4.2 Chemistry of Protein Carbonylation by Reactive Lipid Aldehydes 84\u003c\/p\u003e \u003cp\u003e4.3 Antigenicity of Protein Carbonyls 87\u003c\/p\u003e \u003cp\u003e4.4 Thiolation of Protein Carbonyls 89\u003c\/p\u003e \u003cp\u003e4.5 Reductive Amination]Based Fluorescent Labeling of Protein Carbonyls 91\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Mechanism and Functions of Protein Decarbonylation 97\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eYuichiro J. Suzuki\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Protein Carbonylation 97\u003c\/p\u003e \u003cp\u003e5.2 Primary Protein Carbonylation in Cell Signaling 98\u003c\/p\u003e \u003cp\u003e5.3 Discovery and Mechanisms of Protein Decarbonylation 101\u003c\/p\u003e \u003cp\u003e5.4 Proposed Functions of Protein Decarbonylation in Oxidative Stress and Redox Signaling 103\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Carbonylated Proteins and Their Metabolic Regulation: Overview of Mechanisms, Target Proteins, and Characterization Using Proteomic Methods 110\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSomaieh Afiuni]Zadeh and Timothy J. Griffin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Metabolic Regulation and Reactive Oxygen Species 110\u003c\/p\u003e \u003cp\u003e6.2 ROS and Protein Carbonylation 111\u003c\/p\u003e \u003cp\u003e6.3 Metabolic Control and Characteristics of Carbonylated Proteins 113\u003c\/p\u003e \u003cp\u003e6.4 Protein Targets of Carbonylation and Implications in Human Health 114\u003c\/p\u003e \u003cp\u003e6.5 Technologies and Methods for Characterizing Protein Carbonylation 118\u003c\/p\u003e \u003cp\u003e6.6 Emerging Multifunctional Reagents for Protein Carbonylation Analysis via MS 119\u003c\/p\u003e \u003cp\u003e6.7 Emerging Methods for Characterizing Carbonylated Protein Networks and Affected Pathways 123\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Oxidative Stress and Protein Carbonylation in Malaria 131\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMaria Linares, Antonio Puyet, Amalia Diez, and Jose M. Bautista\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 131\u003c\/p\u003e \u003cp\u003e7.2 Oxidative Stress during Malaria Infection 132\u003c\/p\u003e \u003cp\u003e7.3 Protein Carbonylation in Plasmodium and Oxidative Targeting of Antimalarials 137\u003c\/p\u003e \u003cp\u003e7.4 Oxidative Dysfunction in Host Tissues 143\u003c\/p\u003e \u003cp\u003e7.5 Host Tolerance to Malaria by Modulation of Oxidative Stress Responses 148\u003c\/p\u003e \u003cp\u003e7.6 Perspectives 153\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Protein Carbonylation in Brains of Subjects with Selected Neurodegenerative Disorders 167\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eTanea T. Reed and D. Allan Butterfield\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction to Protein Carbonylation 167\u003c\/p\u003e \u003cp\u003e8.2 Relationship between ROS and Oxidative Stress 169\u003c\/p\u003e \u003cp\u003e8.3 An Overview of Some Neurodegenerative Diseases 171\u003c\/p\u003e \u003cp\u003e8.4 Role of Protein Carbonylation in Brains of Subjects with AD 174\u003c\/p\u003e \u003cp\u003e8.5 An Introduction to Tauopathies 185\u003c\/p\u003e \u003cp\u003e8.6 An Introduction to Amyotrophic Lateral Sclerosis 186\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Cigarette Smoke]Induced Protein Carbonylation: Focus on Recent Human Studies 206\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eGraziano Colombo, Maria Lisa Garavaglia, Aldo Milzani, and Isabella Dalle]Donne\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 206\u003c\/p\u003e \u003cp\u003e9.2 Protein Carbonylation in Human Smokers 212\u003c\/p\u003e \u003cp\u003e9.3 Protein Carbonylation in Cultured Human Cell Models of Exposure to CS 218\u003c\/p\u003e \u003cp\u003e9.4 Limitations and Congruence of In Vivo and In Vitro Human Studies 228\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Chronic Obstructive Pulmonary Disease and Oxidative Damage 241\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eEsther Barreiro\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 242\u003c\/p\u003e \u003cp\u003e10.2 Protein Oxidation in Tissues 244\u003c\/p\u003e \u003cp\u003e10.3 Antioxidants in Skeletal Muscle Fibers 247\u003c\/p\u003e \u003cp\u003e10.4 Implications of Protein Carbonylation in COPD Skeletal Muscle Dysfunction 249\u003c\/p\u003e \u003cp\u003e10.5 Muscle Protein Carbonylation and Exercise in COPD Patients 252\u003c\/p\u003e \u003cp\u003e10.6 Protein Carbonylation in Muscles Exposed to Chronic Cigarette Smoke 253\u003c\/p\u003e \u003cp\u003e10.7 Protein Carbonylation in Cancer Cachexia Models 255\u003c\/p\u003e \u003cp\u003e10.8 Protein Carbonylation as a Predisposing Mechanism of Lung Cancer in COPD 257\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Protein Carbonylation in Aging and Senescence 272\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJeannette Konig, Tobias Jung and Tilman Grune\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 272\u003c\/p\u003e \u003cp\u003e11.2 Protein Oxidation during Aging 274\u003c\/p\u003e \u003cp\u003e11.3 Chemistry of Protein Carbonylation and Fate of Carbonylated Proteins 277\u003c\/p\u003e \u003cp\u003e11.4 Protein Carbonyls in Cellular Aging Models 279\u003c\/p\u003e \u003cp\u003e11.5 Protein Carbonylation in Aging Organisms 280\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Adipose Carbonylation and Mitochondrial Dysfunction 291\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAmy K. Hauck, Dalay H. Olson, Joel S. Burrill, and David A. Bernlohr\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 291\u003c\/p\u003e \u003cp\u003e12.2 Reactive Oxygen Species (ROS) 292\u003c\/p\u003e \u003cp\u003e12.3 Oxidative Stress and Obesity 298\u003c\/p\u003e \u003cp\u003e12.4 Detection of Protein Carbonylation 303\u003c\/p\u003e \u003cp\u003e12.5 Outcomes of Protein Carbonylation 306\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Protein Carbonylation in Plants 321\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eIan Max Moller, Jesper F. Havelund, and Adelina Rogowska]Wrzesinska\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 322\u003c\/p\u003e \u003cp\u003e13.2 Turnover of Reactive Oxygen Species in Plants 323\u003c\/p\u003e \u003cp\u003e13.3 Methods Used in Plants for Quantifying and Identifying Carbonylation Sites 325\u003c\/p\u003e \u003cp\u003e13.4 Protein Carbonylation in Plants 326\u003c\/p\u003e \u003cp\u003e13.5 Protein Carbonylation in Plant Mitochondria 328\u003c\/p\u003e \u003cp\u003e13.6 Protein Carbonylation in Seeds 333\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Specificity of Protein Carbonylation and Its Relevance in Aging 340\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eElisa Cabiscol, Jordi Tamarit, and Joaquim Ros\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 340\u003c\/p\u003e \u003cp\u003e14.2 Specificity of Protein Oxidative Damage 341\u003c\/p\u003e \u003cp\u003e14.3 Protein Carbonylation in Aging 348\u003c\/p\u003e \u003cp\u003eIndex 384\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49406979801431,"sku":"9781119074915","price":136.76,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781119074915.jpg?v=1730497772","url":"https:\/\/bookcurl.com\/products\/protein-carbonylation-9781119074915","provider":"Book Curl","version":"1.0","type":"link"}