{"product_id":"preparation-of-compounds-labeled-with-tritium-and-carbon14-9780470516072","title":"Preparation of Compounds Labeled with Tritium and","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eCompounds tagged with carbon14 and tritium are critical tools in research in biomedical sciences, discovery, and development of pharmaceuticals and agrochemicals, and investigations into the nature of chemical reactions and the ways living organisms incorporate and modify biological components.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003ePreface.  \u003cp\u003e\u003cb\u003eGlossary.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAuthor Biographies.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Physical Properties of Tritium and Carbon-14.\u003c\/p\u003e \u003cp\u003e1.2 Purification.\u003c\/p\u003e \u003cp\u003e1.3 Analysis.\u003c\/p\u003e \u003cp\u003e1.4 Stability and Storage of Compounds Labeled with Tritium or Carbon-14.\u003c\/p\u003e \u003cp\u003e1.5 Specialist Techniques and Equipment.\u003c\/p\u003e \u003cp\u003eReferences .\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Strategies for Target Preparation.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Formulating Target Specifications.\u003c\/p\u003e \u003cp\u003e2.2 Planning Radiotracer Preparations.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Preparation of Tritium-Labeled Compounds by Isotope Exchange Reactions.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Homogeneous Acid- or Base-Catalyzed Exchange.\u003c\/p\u003e \u003cp\u003e3.2 Heterogeneous Catalysis with Tritium in Solvent.\u003c\/p\u003e \u003cp\u003e3.3 Heterogeneous Catalysis in Solution with Tritium Gas.\u003c\/p\u003e \u003cp\u003e3.4 Homogeneous Catalysis in Solution with Tritiated Water.\u003c\/p\u003e \u003cp\u003e3.5 Homogeneous Catalysis with Tritium Gas.\u003c\/p\u003e \u003cp\u003e3.6 Solvent-Free Catalytic Exchange.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Preparation of Tritium-Labeled Compounds by Chemical Synthesis.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Catalytic Tritiations.\u003c\/p\u003e \u003cp\u003e4.2 Catalytic Tritiolyses.\u003c\/p\u003e \u003cp\u003e4.3 Tritide Reductions.\u003c\/p\u003e \u003cp\u003e4.4 Small Tritiated Building Blocks.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Barium [\u003csup\u003e14\u003c\/sup\u003eC]Carbonate and the Preparation of Carbon-14-Labeled Compounds via One-Carbon Building Blocks of the [\u003csup\u003e14\u003c\/sup\u003eC]Carbon Dioxide Tree.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 [\u003csup\u003e14\u003c\/sup\u003eC]Carbon Dioxide (\u003csup\u003e14\u003c\/sup\u003eCO\u003csub\u003e2\u003c\/sub\u003e).\u003c\/p\u003e \u003cp\u003e5.2 [\u003csup\u003e14\u003c\/sup\u003eC]Carbon Monoxide (\u003csup\u003e14\u003c\/sup\u003eCO).\u003c\/p\u003e \u003cp\u003e5.3 [\u003csup\u003e14\u003c\/sup\u003eC]Formic Acid (H\u003csup\u003e14\u003c\/sup\u003eCOOH).\u003c\/p\u003e \u003cp\u003e5.4 [\u003csup\u003e14\u003c\/sup\u003eC]Formaldehyde (H\u003csup\u003e14\u003c\/sup\u003eCHO).\u003c\/p\u003e \u003cp\u003e5.5 [\u003csup\u003e14\u003c\/sup\u003eC]Methyl Iodide (\u003csup\u003e14\u003c\/sup\u003eCH\u003csub\u003e3\u003c\/sub\u003eI).\u003c\/p\u003e \u003cp\u003e5.6 [\u003csup\u003e14\u003c\/sup\u003eC]Nitromethane (\u003csup\u003e14\u003c\/sup\u003eCH\u003csub\u003e3\u003c\/sub\u003eNO\u003csub\u003e2\u003c\/sub\u003e).\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Preparation of Carbon-14-Labeled Compounds via Multi-Carbon Building Blocks of the [\u003csup\u003e14\u003c\/sup\u003eC]Carbon Dioxide Tree.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 [\u003csup\u003e14\u003c\/sup\u003eC]Acetic Acid and Its Derivatives.\u003c\/p\u003e \u003cp\u003e6.2 Halo[\u003csup\u003e14\u003c\/sup\u003eC]acetates.\u003c\/p\u003e \u003cp\u003e6.3 [\u003csup\u003e14\u003c\/sup\u003eC]Acetone.\u003c\/p\u003e \u003cp\u003e6.4 Alkyl [\u003csup\u003e14\u003c\/sup\u003eC]Acetoacetate.\u003c\/p\u003e \u003cp\u003e6.5 [\u003csup\u003e14\u003c\/sup\u003eC]Malonates.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Preparation of Carbon-14-Labeled Compounds via the [\u003csup\u003e14\u003c\/sup\u003eC]Cyanide Tree.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Metal [\u003csup\u003e14\u003c\/sup\u003eC]Cyanides.\u003c\/p\u003e \u003cp\u003e7.2 Preparation of Other Building Blocks from [\u003csup\u003e14\u003c\/sup\u003eC]Cyanide.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Preparation of Carbon-14-Labeled Compounds via the [\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Acetylene Tree.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 [\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Acetylene (H\u003csup\u003e14\u003c\/sup\u003eC≡\u003csup\u003e14\u003c\/sup\u003eCH).\u003c\/p\u003e \u003cp\u003e8.2 [\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Acetaldehyde (\u003csup\u003e14\u003c\/sup\u003eCH\u003csub\u003e3\u003c\/sub\u003e \u003csup\u003e14\u003c\/sup\u003eCHO).\u003c\/p\u003e \u003cp\u003e8.3 [1,2-\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Acetic Acid (\u003csup\u003e14\u003c\/sup\u003eCH\u003csub\u003e3\u003c\/sub\u003e \u003csup\u003e14\u003c\/sup\u003eCOOH).\u003c\/p\u003e \u003cp\u003e8.4 2-[2,3-\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Propyne-1-ol ([2,3-\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Propargyl Alcohol) and 2-[2,3-\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Butyne-1,4-diol.\u003c\/p\u003e \u003cp\u003e8.5 Methyl [2,3-\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Propiolate (H\u003csup\u003e14\u003c\/sup\u003eC≡\u003csup\u003e14\u003c\/sup\u003eCCOOMe) and Dimethyl [2,3-\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Acetylenedicarboxylate (HOOC\u003csup\u003e14\u003c\/sup\u003eC_\u003csup\u003e14\u003c\/sup\u003eCCOOH).\u003c\/p\u003e \u003cp\u003e8.6 1,2-[\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Dibromoethane (Br\u003csup\u003e14\u003c\/sup\u003eCH\u003csub\u003e2\u003c\/sub\u003e \u003csup\u003e14\u003c\/sup\u003eCH\u003csub\u003e2\u003c\/sub\u003eBr).\u003c\/p\u003e \u003cp\u003e8.7 [\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Ethylene Oxide.\u003c\/p\u003e \u003cp\u003e8.8 [\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003en\u003c\/sub\u003e]Benzene and the Synthesis of Ring-Labeled Aromatic Compounds.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Preparation of Carbon-14-Labeled Compounds via the [\u003csup\u003e14\u003c\/sup\u003eC]Cyanamide Tree.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 [\u003csup\u003e14\u003c\/sup\u003eC]Cyanamide (H\u003csub\u003e2\u003c\/sub\u003eN\u003csup\u003e14\u003c\/sup\u003eC≡N).\u003c\/p\u003e \u003cp\u003e9.2 [\u003csup\u003e14\u003c\/sup\u003eC]Guanidine (H\u003csub\u003e2\u003c\/sub\u003eN\u003csup\u003e14\u003c\/sup\u003eC=NH)NH\u003csub\u003e2\u003c\/sub\u003e).\u003c\/p\u003e \u003cp\u003e9.3 [14C]Urea, H2N14CONH2.\u003c\/p\u003e \u003cp\u003e9.4 [\u003csup\u003e14\u003c\/sup\u003eC]Thiourea, H\u003csub\u003e2\u003c\/sub\u003eN\u003csup\u003e14\u003c\/sup\u003eCSNH\u003csub\u003e2\u003c\/sub\u003e .\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Reconstitution Strategies.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Replacement Strategies.\u003c\/p\u003e \u003cp\u003e10.2 Disconnection?Reconnection Strategies.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Preparation of Enantiomerically Pure Compounds Labeled with Isotopes of Hydrogen and Carbon.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Resolution of Racemates.\u003c\/p\u003e \u003cp\u003e11.2 Enantioselective Synthetic Methods.\u003c\/p\u003e \u003cp\u003e11.3 Diastereoselective Synthetic Procedures.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Biotransformations in the Preparation of Compounds Labeled with Carbon and Hydrogen Isotopes.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Applications of Isolated Enzymes.\u003c\/p\u003e \u003cp\u003e12.2 Application of Cell-Containing Systems.\u003c\/p\u003e \u003cp\u003e12.3 Biocatalyzed Synthesis of Key Intermediates for Reconstitution Approaches.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default 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