{"product_id":"practical-synthetic-organic-chemistry-9781119448853","title":"Practical Synthetic Organic Chemistry","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book is a hands-on guide for the organic chemist. Focusing on the most reliable and useful reactions, the chapter authors provide the information necessary for a chemist to strategically plan a synthesis, as well as repeat the procedures in the laboratory.\u003cbr\u003e\u003cbr\u003e \u003cul\u003e \u003cli\u003eConsolidates all the key advances\/concepts in one book, covering the most important reactions in organic chemistry, including substitutions, additions, eliminations, rearrangements, oxidations, reductions\u003c\/li\u003e \u003cli\u003eHighlights the most important reactions, addressing basic principles, advantages\/disadvantages of the methodology, mechanism, and techniques for achieving laboratory success\u003c\/li\u003e \u003cli\u003eFeatures new content on recent advances in CH activation, photoredox and electrochemistry, continuous chemistry, and application of biocatalysis in synthesis\u003c\/li\u003e \u003cli\u003eRevamps chapters to include new and additional examples of chemistry that have been demonstrated at a practical scale\u003c\/li\u003e \u003c\/ul\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eList of Contributors xxxi\u003c\/p\u003e \u003cp\u003ePreface xxxiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Aliphatic Nucleophilic Substitution \u003c\/b\u003e\u003cb\u003e1\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJade D. Nelson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.2 Oxygen Nucleophiles 1\u003c\/p\u003e \u003cp\u003e1.3 Phosphorus Nucleophiles 21\u003c\/p\u003e \u003cp\u003e1.4 Sulfur Nucleophiles 21\u003c\/p\u003e \u003cp\u003e1.5 Nitrogen Nucleophiles 26\u003c\/p\u003e \u003cp\u003e1.6 Halogen Nucleophiles 38\u003c\/p\u003e \u003cp\u003e1.7 Carbon Nucleophiles 47\u003c\/p\u003e \u003cp\u003e1.8 Nucleophilic Substitution at a Sulfonyl Sulfur Atom 60\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Addition to Carbon-Heteroatom Multiple Bonds \u003c\/b\u003e\u003cb\u003e65\u003cbr\u003e\u003c\/b\u003e\u003ci\u003ePrantik Maity and Rajappa Vaidyanathan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 66\u003c\/p\u003e \u003cp\u003e2.2 Addition of Water to Aldehydes and Ketones: Formation of Hydrates 66\u003c\/p\u003e \u003cp\u003e2.3 Addition of Bisulfite to Aldehydes and Ketones 67\u003c\/p\u003e \u003cp\u003e2.4 The Addition of Alcohols to Aldehydes and Ketones: Acetal Formation 69\u003c\/p\u003e \u003cp\u003e2.5 The Addition of Thiols to Aldehydes and Ketones: S,S-Acetal Formation 71\u003c\/p\u003e \u003cp\u003e2.6 Reductive Etherification 72\u003c\/p\u003e \u003cp\u003e2.7 Addition of NH\u003csub\u003e3\u003c\/sub\u003e, RNH\u003csub\u003e2\u003c\/sub\u003e, and R\u003csub\u003e2\u003c\/sub\u003eNH 74\u003c\/p\u003e \u003cp\u003e2.8 Formation of Hydrazones 79\u003c\/p\u003e \u003cp\u003e2.9 Formation of Oximes 80\u003c\/p\u003e \u003cp\u003e2.10 The Formation of gem-Dihalides from Aldehydes and Ketones 80\u003c\/p\u003e \u003cp\u003e2.11 The Aldol Reaction 82\u003c\/p\u003e \u003cp\u003e2.12 Allylorganometallics: Stannane, Borane, and Silane 92\u003c\/p\u003e \u003cp\u003e2.13 The Nozaki–Hiyama–Kishi Reaction 97\u003c\/p\u003e \u003cp\u003e2.14 Addition of Transition Metal Alkynylides to Carbonyl Compounds 99\u003c\/p\u003e \u003cp\u003e2.15 Addition of Organometallic Reagents to Carbonyls 100\u003c\/p\u003e \u003cp\u003e2.17 The Reformatsky Reaction 104\u003c\/p\u003e \u003cp\u003e2.18 The Wittig Reaction 106\u003c\/p\u003e \u003cp\u003e2.19 Horner–Wadsworth–Emmons Reaction 108\u003c\/p\u003e \u003cp\u003e2.20 Peterson Olefination 109\u003c\/p\u003e \u003cp\u003e2.21 Julia–Lythgoe Olefination 110\u003c\/p\u003e \u003cp\u003e2.22 Tebbe Methylenation 112\u003c\/p\u003e \u003cp\u003e2.23 The Mannich Reaction 113\u003c\/p\u003e \u003cp\u003e2.24 The Strecker Reaction 115\u003c\/p\u003e \u003cp\u003e2.25 Hydrolysis of Carbon–Nitrogen Double Bonds 117\u003c\/p\u003e \u003cp\u003e2.26 Conversion of Carboxylic Acids to Acyl Chlorides 118\u003c\/p\u003e \u003cp\u003e2.27 Synthesis of Acyl Fluorides from Carboxylic Acids 122\u003c\/p\u003e \u003cp\u003e2.28 Formation of Amides from Carboxylic Acids 123\u003c\/p\u003e \u003cp\u003e2.29 Formation of Amides from Esters 130\u003c\/p\u003e \u003cp\u003e2.30 Hydrolysis of Acyl Halides 132\u003c\/p\u003e \u003cp\u003e2.31 Conversion of Carboxylic Acids to Esters 132\u003c\/p\u003e \u003cp\u003e2.32 Hydrolysis of Amides 136\u003c\/p\u003e \u003cp\u003e2.33 Conversion of N-Acyloxazolidinones to Other Carboxyl Derivatives 139\u003c\/p\u003e \u003cp\u003e2.34 Alcoholysis of Amides 140\u003c\/p\u003e \u003cp\u003e2.35 Hydrolysis of Esters 141\u003c\/p\u003e \u003cp\u003e2.36 Transesterification 143\u003c\/p\u003e \u003cp\u003e2.37 Alkyl Thiol Addition to Esters 144\u003c\/p\u003e \u003cp\u003e2.38 Addition of Organometallic Reagents to Carboxylic Acid Derivatives 145\u003c\/p\u003e \u003cp\u003e2.39 The Kulinkovich Cyclopropanation 149\u003c\/p\u003e \u003cp\u003e2.40 Synthesis of Acyl Cyanides 150\u003c\/p\u003e \u003cp\u003e2.41 The Ritter Reaction 151\u003c\/p\u003e \u003cp\u003e2.42 Thorpe Reaction 154\u003c\/p\u003e \u003cp\u003e2.43 Addition of Organometallic Reagents to Nitriles 155\u003c\/p\u003e \u003cp\u003e2.44 Conversion of Nitriles to Amides, Esters, and Carboxylic Acids 155\u003c\/p\u003e \u003cp\u003e2.45 Conversion of Nitriles to Thioamides 158\u003c\/p\u003e \u003cp\u003e2.46 The Addition of Ammonia or Amines to Nitriles 160\u003c\/p\u003e \u003cp\u003e2.47 The Addition of Alcohol to Nitriles 161\u003c\/p\u003e \u003cp\u003e2.48 Alkyl Thiol Addition to Nitriles 162\u003c\/p\u003e \u003cp\u003e2.49 The Blaise Reaction 162\u003c\/p\u003e \u003cp\u003e2.50 The Addition of Alcohols to Isocyanates 163\u003c\/p\u003e \u003cp\u003e2.51 The Addition of Amines and Amides to Isocyanates 164\u003c\/p\u003e \u003cp\u003e2.52 The Formation of Xanthates 165\u003c\/p\u003e \u003cp\u003e2.53 The Addition of Amines to Carbon Dioxide 166\u003c\/p\u003e \u003cp\u003e2.54 The Addition of Amines to Carbon Disulfide 167\u003c\/p\u003e \u003cp\u003e2.55 Addition of Organometallic Reagents to Carbon Dioxide 167\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Addition to Carbon–Carbon Multiple Bonds \u003c\/b\u003e\u003cb\u003e169\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJohn A. Ragan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 169\u003c\/p\u003e \u003cp\u003e3.2 Hydrogen–Halogen Addition (Hydrohalogenation) 169\u003c\/p\u003e \u003cp\u003e3.3 Hydrogen–Oxygen Addition 173\u003c\/p\u003e \u003cp\u003e3.4 Hydrogen–Nitrogen Addition (Hydroamination) 178\u003c\/p\u003e \u003cp\u003e3.5 Hydrogen–Carbon Addition (Hydroalkylation) 180\u003c\/p\u003e \u003cp\u003e3.6 Halogen–Halogen Addition 191\u003c\/p\u003e \u003cp\u003e3.7 Hydroxy–Halogen Addition 192\u003c\/p\u003e \u003cp\u003e3.8 Amino–Halogen Addition 194\u003c\/p\u003e \u003cp\u003e3.9 Carbon–Halogen Addition 194\u003c\/p\u003e \u003cp\u003e3.10 Oxygen–Oxygen Addition 196\u003c\/p\u003e \u003cp\u003e3.11 Oxygen–Nitrogen Addition 202\u003c\/p\u003e \u003cp\u003e3.12 Nitrogen–Nitrogen Addition 204\u003c\/p\u003e \u003cp\u003e3.13 Carbon–Oxygen Addition 206\u003c\/p\u003e \u003cp\u003e3.14 Carbon–Nitrogen Addition 211\u003c\/p\u003e \u003cp\u003e3.15 Carbon–Carbon Addition 212\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Nucleophilic Aromatic Substitution \u003c\/b\u003e\u003cb\u003e231\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eStéphane Caron and Emma McInturff\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 231\u003c\/p\u003e \u003cp\u003e4.2 Oxygen Nucleophiles 232\u003c\/p\u003e \u003cp\u003e4.3 Sulfur Nucleophiles 234\u003c\/p\u003e \u003cp\u003e4.4 Nitrogen Nucleophiles 236\u003c\/p\u003e \u003cp\u003e4.5 Halogen Nucleophiles 241\u003c\/p\u003e \u003cp\u003e4.6 Carbon Nucleophiles 243\u003c\/p\u003e \u003cp\u003e4.7 ortho-Arynes 245\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Electrophilic Aromatic Substitution \u003c\/b\u003e\u003cb\u003e247\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eStéphane Caron and Emma McInturff\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 247\u003c\/p\u003e \u003cp\u003e5.2 Nitrogen Electrophiles 247\u003c\/p\u003e \u003cp\u003e5.3 Sulfur Electrophiles 250\u003c\/p\u003e \u003cp\u003e5.4 Halogenation 253\u003c\/p\u003e \u003cp\u003e5.5 Carbon Electrophiles 257\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Selected Catalytic Reactions \u003c\/b\u003e\u003cb\u003e269\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSebastien Monfette, Adam R. Brown, Pascal Dubé, Nathan D. Ide, Chad A. Lewis, Jared L. Piper, \u003c\/i\u003e\u003ci\u003eShashank Shekhar, and Shu Yu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 269\u003c\/p\u003e \u003cp\u003e6.2 Organoboron Reagents:The Suzuki–Miyaura Coupling 270\u003c\/p\u003e \u003cp\u003e6.3 Organomagnesium Reagents: Kumada–Corriu Coupling 282\u003c\/p\u003e \u003cp\u003e6.4 Organozinc Reagents: Negishi Coupling 287\u003c\/p\u003e \u003cp\u003e6.5 Cross-Electrophile Coupling 291\u003c\/p\u003e \u003cp\u003e6.6 Organotin Reagents: The Stille Coupling (Migita-Stille Reaction) 292\u003c\/p\u003e \u003cp\u003e6.7 Cross-Coupling Reactions with Organosilicon Compounds 295\u003c\/p\u003e \u003cp\u003e6.8 Metal-catalyzed Coupling of Alkynes (Sonogashira Coupling) 296\u003c\/p\u003e \u003cp\u003e6.9 Metal-Catalyzed Coupling of Alkenes (Heck Coupling) 298\u003c\/p\u003e \u003cp\u003e6.10 Enolate Arylations 303\u003c\/p\u003e \u003cp\u003e6.11 Pd- and Cu-Catalyzed Aryl C—N Bond Formation 306\u003c\/p\u003e \u003cp\u003e6.12 Pd- and Cu-Catalyzed Aryl C—O Bond Formation 320\u003c\/p\u003e \u003cp\u003e6.13 Pd- and Cu-Catalyzed Aryl C—S Bond Formation 322\u003c\/p\u003e \u003cp\u003e6.14 Aryl C—B Bond Formation 324\u003c\/p\u003e \u003cp\u003e6.15 Pd-Catalyzed Aryl C—CN Bond Formation 327\u003c\/p\u003e \u003cp\u003e6.16 Metal-Catalyzed Allylic Substitution 329\u003c\/p\u003e \u003cp\u003e6.17 Catalytic Metal-Mediated Methods for Fluorination 337\u003c\/p\u003e \u003cp\u003e6.18 Selected Metal-Mediated C—H Functionalization 347\u003c\/p\u003e \u003cp\u003e6.19 C—X Bond Forming Reactions via Borrowed Hydrogen Methodologies 357\u003c\/p\u003e \u003cp\u003e6.20 Alkene and Alkyne Metathesis Reactions 362\u003c\/p\u003e \u003cp\u003e6.21 Organocatalysis 369\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Rearrangements \u003c\/b\u003e\u003cb\u003e377\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDavid H. Brown Ripin and Chad A. Lewis\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 377\u003c\/p\u003e \u003cp\u003e7.2 [1,2]-Rearrangements 377\u003c\/p\u003e \u003cp\u003eOther Rearrangements 402\u003c\/p\u003e \u003cp\u003e7.3 Other Rearrangements 402\u003c\/p\u003e \u003cp\u003e7.4 Miscellaneous Migrations 420\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Eliminations \u003c\/b\u003e\u003cb\u003e425\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSally Gut Ruggeri\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 425\u003c\/p\u003e \u003cp\u003e8.2 Formation of Alkenes 425\u003c\/p\u003e \u003cp\u003e8.3 Formation of Dienes 438\u003c\/p\u003e \u003cp\u003e8.4 Formation of Alkynes 442\u003c\/p\u003e \u003cp\u003e8.5 Formation of C=N bonds 444\u003c\/p\u003e \u003cp\u003e8.6 Formation of Nitriles 445\u003c\/p\u003e \u003cp\u003e8.7 Formation of Ketenes and Related Compounds 447\u003c\/p\u003e \u003cp\u003e8.8 Fragmentations 449\u003c\/p\u003e \u003cp\u003e8.9 Dehydrating Reagents 451\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Reductions \u003c\/b\u003e\u003cb\u003e455\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSally Gut Ruggeri, Stéphane Caron, Pascal Dubé, Nathan D. Ide, Kristin E. Price Wiglesworth, John A. Ragan, and Shu Yu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 455\u003c\/p\u003e \u003cp\u003e9.2 Reduction of C—C Bonds 455\u003c\/p\u003e \u003cp\u003e9.3 Reduction of C—N Bonds 471\u003c\/p\u003e \u003cp\u003e9.4 Reduction of C—O Bonds 479\u003c\/p\u003e \u003cp\u003e9.5 Reduction of C—S Bonds 494\u003c\/p\u003e \u003cp\u003e9.6 Reduction of C—X Bonds 500\u003c\/p\u003e \u003cp\u003e9.7 Reduction of Heteroatom–Heteroatom Bonds 504\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Oxidations \u003c\/b\u003e\u003cb\u003e513\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eEric C. Hansen, Robert Perkins, and David H. Brown Ripin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 513\u003c\/p\u003e \u003cp\u003e10.2 Oxidation of C—C Single and Double Bonds 514\u003c\/p\u003e \u003cp\u003e10.3 Oxidation of C—H Bonds 520\u003c\/p\u003e \u003cp\u003e10.4 Oxidation of Carbon–Oxygen Bonds and at Carbon Bearing an Oxygen Substituent 536\u003c\/p\u003e \u003cp\u003e10.5 Oxidation of Aldehydes to Carboxylic Acids and Derivatives 543\u003c\/p\u003e \u003cp\u003e10.6 Oxidation of Carbon–Nitrogen Bonds and at Carbon Bearing a Nitrogen Substituent 546\u003c\/p\u003e \u003cp\u003e10.7 Oxidation of Nitrogen Functionalities 548\u003c\/p\u003e \u003cp\u003e10.8 Oxidation of Sulfur and at Carbon Adjacent to Sulfur 555\u003c\/p\u003e \u003cp\u003e10.9 Oxidation of Other Functionality 561\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Selected Free Radical Reactions \u003c\/b\u003e\u003cb\u003e563\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eChristophe Allais, Eric C. Hansen, Nathan D. Ide, Robert J. Perkins, and Elizabeth C. Swift\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 563\u003c\/p\u003e \u003cp\u003e11.2 Radical Reactions via Chemical Initiation 563\u003c\/p\u003e \u003cp\u003e11.3 Photoredox Catalysis 575\u003c\/p\u003e \u003cp\u003e11.4 Electrochemical Methods 583\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Synthesis of “Nucleophilic” Organometallic Reagents \u003c\/b\u003e\u003cb\u003e591\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDavid H. Brown Ripin and Adam R. Brown\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 591\u003c\/p\u003e \u003cp\u003e12.2 Synthesis of “Nucleophilic” Organometallic Reagents 592\u003c\/p\u003e \u003cp\u003e12.3 Strategies for Metalating Heterocycles 615\u003c\/p\u003e \u003cp\u003e12.4 Reactions of “Nucleophilic” Organometallic Reagents 618\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Synthesis of Common Aromatic Heterocycles \u003c\/b\u003e\u003cb\u003e621\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eStéphane Caron\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 621\u003c\/p\u003e \u003cp\u003e13.2 Pyrroles 623\u003c\/p\u003e \u003cp\u003e13.3 Indoles 624\u003c\/p\u003e \u003cp\u003e13.4 2-Indolinones (Oxindoles) 626\u003c\/p\u003e \u003cp\u003e13.5 Isatins (2,3-Indolindiones) 628\u003c\/p\u003e \u003cp\u003e13.6 Carbazoles 628\u003c\/p\u003e \u003cp\u003e13.7 Pyrazoles 629\u003c\/p\u003e \u003cp\u003e13.8 Indazoles 630\u003c\/p\u003e \u003cp\u003e13.9 Imidazoles and Benzimidazoles 631\u003c\/p\u003e \u003cp\u003e13.10 1,2,3-Triazoles and Benzotriazole 633\u003c\/p\u003e \u003cp\u003e13.11 1,2,4-Triazoles 635\u003c\/p\u003e \u003cp\u003e13.12 Tetrazoles 635\u003c\/p\u003e \u003cp\u003e13.13 Dihydropyridines 637\u003c\/p\u003e \u003cp\u003e13.14 Pyridines 637\u003c\/p\u003e \u003cp\u003e13.15 Quinolines 639\u003c\/p\u003e \u003cp\u003e13.16 Quinolinones and 2-Hydroxyquinolines 641\u003c\/p\u003e \u003cp\u003e13.17 Isoquinolines 642\u003c\/p\u003e \u003cp\u003e13.18 Isoquinolinones 643\u003c\/p\u003e \u003cp\u003e13.19 Quinolones (4-Hydroxyquinolines) 644\u003c\/p\u003e \u003cp\u003e13.20 Pyrimidines and Pyrimidones 645\u003c\/p\u003e \u003cp\u003e13.21 Quinazolines and Quinazolinones 647\u003c\/p\u003e \u003cp\u003e13.22 Pyrazines and Quinoxalines 648\u003c\/p\u003e \u003cp\u003e13.23 Pyridazines, Phtalazines, and Cinnolines 650\u003c\/p\u003e \u003cp\u003e13.24 1,2,4-Triazines 651\u003c\/p\u003e \u003cp\u003e13.25 Furans and Benzofurans 652\u003c\/p\u003e \u003cp\u003e13.26 Benzopyran-4-One (Chromen-4-One, Flavone) and Xanthone 653\u003c\/p\u003e \u003cp\u003e13.27 Coumarins 655\u003c\/p\u003e \u003cp\u003e13.28 Thiophenes and Benzothiophenes 656\u003c\/p\u003e \u003cp\u003e13.29 Isoxazoles and Benzisoxazoles 657\u003c\/p\u003e \u003cp\u003e13.30 Oxazoles and Benzoxazoles 659\u003c\/p\u003e \u003cp\u003e13.31 Isothiazoles and Benzisothiazoles 660\u003c\/p\u003e \u003cp\u003e13.32 Thiazoles and Benzothiazoles 661\u003c\/p\u003e \u003cp\u003e13.33 1,2,4-Oxadiazoles 662\u003c\/p\u003e \u003cp\u003e13.34 1,3,4-Oxadiazoles 663\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Access to Chirality \u003c\/b\u003e\u003cb\u003e665\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAngela L. A. Puchlopek-Dermenci and Robert W. Dugger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 665\u003c\/p\u003e \u003cp\u003e14.2 Using the Chiral Pool 665\u003c\/p\u003e \u003cp\u003e14.3 Classical Resolutions 668\u003c\/p\u003e \u003cp\u003e14.4 Dynamic Kinetic Resolutions 673\u003c\/p\u003e \u003cp\u003e14.5 Desymmetrization of Meso Compounds 675\u003c\/p\u003e \u003cp\u003e14.6 Chiral Chromatography 676\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Biocatalysis \u003c\/b\u003e\u003cb\u003e679\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eCarlos A. Martinez, Rajesh Kumar, and John Wong\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction 679\u003c\/p\u003e \u003cp\u003e15.2 Group Transfer Reactions 682\u003c\/p\u003e \u003cp\u003e15.3 Reductions 688\u003c\/p\u003e \u003cp\u003e15.4 Oxidations 693\u003c\/p\u003e \u003cp\u003e15.5 C—C Bond Forming Reactions 699\u003c\/p\u003e \u003cp\u003e15.6 Future Developments 703\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Green Chemistry \u003c\/b\u003e\u003cb\u003e705\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJuan Colberg, Jared L. Piper, and John Wong\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction 705\u003c\/p\u003e \u003cp\u003e16.2 Green Chemistry Metrics 706\u003c\/p\u003e \u003cp\u003e16.3 Solvent and Reagent Selection 710\u003c\/p\u003e \u003cp\u003e16.4 Green Reactions\/Reagents 716\u003c\/p\u003e \u003cp\u003e16.5 Examples of Green Methods and Reagents for Common Reaction Types 716\u003c\/p\u003e \u003cp\u003e16.6 Predictive Tools to Design for Green Chemistry 724\u003c\/p\u003e \u003cp\u003e16.7 Green Chemistry Improvements in Process Development 725\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Continuous Chemistry \u003c\/b\u003e\u003cb\u003e729\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDavid D. Ford, Robert J.Maguire, J. Christopher McWilliams, Bryan Li, and Jared L. Piper\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17.1 Introduction 729\u003c\/p\u003e \u003cp\u003e17.2 Aliphatic Nucleophilic Substitutions 731\u003c\/p\u003e \u003cp\u003e17.3 Additions to C—Het Multiple Bonds 735\u003c\/p\u003e \u003cp\u003e17.4 Addition to C—C Multiple Bonds 735\u003c\/p\u003e \u003cp\u003e17.5 Nucleophilic Aromatic Substitutions 739\u003c\/p\u003e \u003cp\u003e17.6 Electrophilic Aromatic Substitution 739\u003c\/p\u003e \u003cp\u003e17.7 Catalysis 741\u003c\/p\u003e \u003cp\u003e17.8 Rearrangements 743\u003c\/p\u003e \u003cp\u003e17.9 Eliminations 746\u003c\/p\u003e \u003cp\u003e17.10 Reductions 748\u003c\/p\u003e \u003cp\u003e17.11 Oxidations 751\u003c\/p\u003e \u003cp\u003e17.12 Free Radical Reactions 757\u003c\/p\u003e \u003cp\u003e17.13 Syntheses of Organometallic Reagents 760\u003c\/p\u003e \u003cp\u003e17.14 Synthesis of Aromatic Heterocycles 766\u003c\/p\u003e \u003cp\u003e17.15 Access to Chirality 770\u003c\/p\u003e \u003cp\u003e17.16 Biotransformations 771\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 General Solvent Properties \u003c\/b\u003e\u003cb\u003e773\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eStéphane Caron\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18.1 Introduction 773\u003c\/p\u003e \u003cp\u003e18.2 Definitions and Acronyms 774\u003c\/p\u003e \u003cp\u003e18.3 Solvent Properties 775\u003c\/p\u003e \u003cp\u003e18.4 Mutual Solubility of Water and Organic Solvents 778\u003c\/p\u003e \u003cp\u003e18.5 Other Useful Information on Solvents 779\u003c\/p\u003e \u003cp\u003e18.6 Solvent Safety 780\u003c\/p\u003e \u003cp\u003e18.7 Risk Phrases Used in the Countries of EU 781\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Practical Chemistry Concepts Tips for the Practicing Chemist or Things They Don’t Teach You in School \u003c\/b\u003e\u003cb\u003e785\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSally Gut Ruggeri\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19.1 Introduction 785\u003c\/p\u003e \u003cp\u003e19.2 Reaction Execution 785\u003c\/p\u003e \u003cp\u003e19.3 Solvents and Reagents 788\u003c\/p\u003e \u003cp\u003e19.4 Isolation 793\u003c\/p\u003e \u003cp\u003e19.5 Analysis 797\u003c\/p\u003e \u003cp\u003eSubject Index 801\u003c\/p\u003e \u003cp\u003eCombo Index 811\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":48866395914583,"sku":"9781119448853","price":999.99,"currency_code":"GBP","in_stock":false}],"url":"https:\/\/bookcurl.com\/products\/practical-synthetic-organic-chemistry-9781119448853","provider":"Book Curl","version":"1.0","type":"link"}