{"product_id":"practical-methods-for-biocatalysis-and-biotransformations-volume-3-1-9781118605257","title":"Practical Methods for Biocatalysis and","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eBiocatalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there exists a huge choice of high-tech enzymes and whole cell biocatalysts, which add enormously to the repertoire of synthetic possibilities.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eList of Contributors ix\u003c\/p\u003e \u003cp\u003eAbbreviations xxi\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Considerations for the Application of Process Technologies in Laboratory- and Pilot-Scale Biocatalysis for Chemical Synthesis 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.2 Process Intensification and Proposed Scale-Up Concept 2\u003c\/p\u003e \u003cp\u003e1.3 Enabling Technologies 5\u003c\/p\u003e \u003cp\u003e1.4 Enhancing Technologies 20\u003c\/p\u003e \u003cp\u003e1.5 Conclusion 28\u003c\/p\u003e \u003cp\u003eReferences 28\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Cytochrome P450 (CYP) Progress in Biocatalysis for Synthetic Organic Chemistry 31\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 31\u003c\/p\u003e \u003cp\u003e2.2 CYP Development 32\u003c\/p\u003e \u003cp\u003e2.3 Recent Developments 34\u003c\/p\u003e \u003cp\u003e2.4 Conclusion 41\u003c\/p\u003e \u003cp\u003eReferences 41\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Use of Hydrolases and Related Enzymes for Synthesis 43\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Continuous-Flow Reactor-Based Enzymatic Synthesis of Phosphorylated Compounds on a Large Scale 43\u003c\/p\u003e \u003cp\u003e3.2 Deracemization of sec-Alcohols via Enantio-Convergent Hydrolysis of rac-Sulfate Esters 45\u003c\/p\u003e \u003cp\u003e3.3 Dynamic Kinetic Resolution of a Primary Amine by an Efficient Bifunctional Pd-CALB Hybrid Catalyst. A Metalloenzyme Mimic for Enhanced Cooperative Catalysis 50\u003c\/p\u003e \u003cp\u003e3.4 Highly Efficient DKR of Secondary 1-Phenylethanol Derivatives Using a Low-Cost Solid Super Acid as Racemization Catalyst 53\u003c\/p\u003e \u003cp\u003e3.5 Identification of New Biocatalysts for the Enantioselective Conversion of Tertiary Alcohols 58\u003c\/p\u003e \u003cp\u003e3.6 Enzyme-Catalyzed Hydrolysis of Bicycloheptane Diester to Monoester 60\u003c\/p\u003e \u003cp\u003e3.7 Double Mutant Lipase with Enhanced Activity and Enantioselectivity for Bulky Secondary Alcohols 64\u003c\/p\u003e \u003cp\u003e3.8 Stereoselective Synthesis of β-Amino Acids by Hydrolysis of an Aryl-Substituted Dihydropyrimidine by Hydantoinases 68\u003c\/p\u003e \u003cp\u003eReferences 72\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Non-Redox Lyases and Transferases for C-C, C-O, C-S, and C-N Bond Formation 75\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Regioselective Enzymatic Carboxylation of Phenols and Hydroxystyrenes Employing Co-Factor-Independent Decarboxylases 75\u003c\/p\u003e \u003cp\u003e4.2 Stetter Reactions Catalyzed by Thiamine Diphosphate-Dependent Enzymes 81\u003c\/p\u003e \u003cp\u003e4.3 Asymmetric Michael-Type Additions of Acetaldehyde to Nitroolefins Catalyzed by 4-Oxalocrotonate Tautomerase (4-OT) Yielding Valuable γ-Nitroaldehydes 85\u003c\/p\u003e \u003cp\u003e4.4 Michael-Type Addition of Aldehydes to β-Nitrostyrenes by Whole Cells of Escherichia coli Expressing 4-Oxalocrotonate Tautomerase (4-OT) 91\u003c\/p\u003e \u003cp\u003e4.5 Norcoclaurine Synthases for the Biocatalytic Synthesis of Tetrahydroisoquinolines 95\u003c\/p\u003e \u003cp\u003e4.6 Streptavidin-Based Artificial Metallo-Annulase for the Enantioselective Synthesis of Dihydroisoquinolones 101\u003c\/p\u003e \u003cp\u003e4.7 Regiospecific Benzylation of Tryptophan and Derivatives Catalyzed by a Fungal Dimethylallyl Transferase 102\u003c\/p\u003e \u003cp\u003e4.8 Enantioselective Michael Addition of Water Using Rhodococcus Rhodochrous ATCC 17895 106\u003c\/p\u003e \u003cp\u003e4.9 Sulfation of Various Compounds by an Arylsulfotransferase from Desulfitobacterium hafniense and Synthesis of 17β-Estradiol-3-Sulfate 111\u003c\/p\u003e \u003cp\u003e4.10 Asymmetric Synthesis of Cyclopropanes and Benzosultams via Enzyme-Catalyzed Carbenoid and Nitrenoid Transfer in E. coli Whole Cells 113\u003c\/p\u003e \u003cp\u003e4.11 Biocatalytic Production of Novel Glycolipids 118\u003c\/p\u003e \u003cp\u003e4.12 Enzymatic Synthesis of 8-Aza- and 8-Aza-7-Deazapurine 2´-Deoxyribonucleosides 124\u003c\/p\u003e \u003cp\u003e4.13 Phenylalanine Ammonia Lyase-Catalyzed Asymmetric Hydroamination for the Synthesis of L-Amino Acids 128\u003c\/p\u003e \u003cp\u003eReferences 130\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Oxidations 135\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Semi-Preparative-Scale Drug Metabolite Synthesis with Human Flavin Monooxygenases 135\u003c\/p\u003e \u003cp\u003e5.2 Biobased Synthesis of Industrially Relevant Nitriles by Selective Oxidative Decarboxylation of Amino Acids by Vanadium Chloroperoxidase 139\u003c\/p\u003e \u003cp\u003e5.3 Terminal Oxygenation of Fatty Acids by a CYP153A Fusion Construct Heterologously Expressed in E. coli 142\u003c\/p\u003e \u003cp\u003e5.4 Enantioselective Oxidative C-C Bond Formation in Isoquinoline Alkaloids Employing the Berberine Bridge Enzyme 144\u003c\/p\u003e \u003cp\u003e5.5 Oxidation of Aldehydes Using Alcohol Dehydrogenases 148\u003c\/p\u003e \u003cp\u003e5.6 MAO-Catalyzed Deracemization of Racemic Amines for the Synthesis of Pharmaceutical Building Blocks 150\u003c\/p\u003e \u003cp\u003e5.7 Synthesis of (S)-Amines by Chemo-Enzymatic Deracemization Using an (R)-Selective Amine Oxidase 153\u003c\/p\u003e \u003cp\u003e5.8 Selective Oxidation of Diols into Lactones under Aerobic Conditions Using a Laccase-TEMPO Catalytic System in Aqueous Medium 156\u003c\/p\u003e \u003cp\u003eReferences 160\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Reductions 163\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Tetrahydroxynaphthalene Reductase: Broad Substrate Range of an NADPH-Dependent Oxidoreductase Involved in Reductive Asymmetric Naphthol Dearomatization 163\u003c\/p\u003e \u003cp\u003e6.2 Chemoenzymatic Synthesis of Diastereo- and Enantiomerically Pure 2,6-Disubstituted Piperidines via Regioselective Monoamination of 1,5-Diketones 167\u003c\/p\u003e \u003cp\u003e6.3 Asymmetric Amination of Ketones Employing ω-TAs in Organic Solvents 171\u003c\/p\u003e \u003cp\u003e6.4 Stereoselective Synthesis of (R)-Profen Derivatives by the Enoate Reductase YqjM 176\u003c\/p\u003e \u003cp\u003e6.5 Productivity Improvement of the Bioreduction of α,β-Unsaturated Aldehydes by Coupling of the In Situ Substrate Feeding Product Removal (SFPR) Strategy with Isolated Enzymes 181\u003c\/p\u003e \u003cp\u003e6.6 Reduction of Imines by Recombinant Whole-Cell E. coli Biocatalysts Expressing Imine Reductases (IREDs) 186\u003c\/p\u003e \u003cp\u003eReferences 191\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Halogenation and Dehalogenation 193\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Site-Directed Mutagenesis Changes the Regioselectivity of the Tryptophan 7-Halogenase PrnA 193\u003c\/p\u003e \u003cp\u003e7.2 Controlling Enantioselectivity of Halohydrin Dehalogenase from Arthrobacter sp. Strain AD2, Revealed by Structure-Guided Directed Evolution 197\u003c\/p\u003e \u003cp\u003e7.3 Enzymatic Production of Chlorothymol and its Derivatives by Halogenation of the Phenolic Monoterpenes Thymol and Carvacrol with Chloroperoxidase 201\u003c\/p\u003e \u003cp\u003e7.4 Halogenation of Non-Activated Fatty Acyl Groups by a Trifunctional Non-Heme Fe(II)-Dependent Halogenase 204\u003c\/p\u003e \u003cp\u003eReferences 211\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Cascade Reactions 213\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Synthetic Cascades via a Combination of Artificial Metalloenzymes with Monoamine Oxidases (MAO-Ns) 213\u003c\/p\u003e \u003cp\u003e8.2 Amination of Primary Alcohols via a Redox-Neutral Biocascade 215\u003c\/p\u003e \u003cp\u003e8.3 Biocatalytic Synthesis of a Diketobornane as a Building Block for Bifunctional Camphor Derivatives 218\u003c\/p\u003e \u003cp\u003e8.4 Three Enzyme-Catalyzed Redox Cascade for the Production of a Carvo-Lactone 222\u003c\/p\u003e \u003cp\u003e8.5 Preparation of Homoallylic Alcohols via a Chemoenzymatic One-Pot Oxidation-Allylation Cascade 226\u003c\/p\u003e \u003cp\u003e8.6 Cascade Biotransformations via Enantioselective Reduction, Oxidation, and Hydrolysis: Preparation of (R)-δ-Lactones from 2-Alkylidenecyclopentanones 230\u003c\/p\u003e \u003cp\u003e8.7 One-Pot Tandem Enzymatic Reactions for Efficient Biocatalytic Synthesis of D-Fructose-6-Phosphate and Analogs 232\u003c\/p\u003e \u003cp\u003e8.8 Efficient One-Pot Tandem Biocatalytic Process for a Valuable Phosphorylated C8 D-Ketose: D-Glycero-D-Altro-2-Octulose 8-Phosphate 239\u003c\/p\u003e \u003cp\u003e8.9 Chemoenzymatic Synthesis of (S)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid by PAL-Mediated Amination and Pictet-Spengler Cyclization 243\u003c\/p\u003e \u003cp\u003e8.10 ω-TA\/MAO Cascade for the Regio- and Stereoselective Synthesis of Chiral 2,5-Disubstituted Pyrrolidines 246\u003c\/p\u003e \u003cp\u003eReferences 249\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Biocatalysis for Industrial Process Development 253\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Efficient Synthesis of (S)-1-(5-Fluoropyrimidin-2-yl)ethylamine Hydrochloride Salt Using an ω-Transaminase Biocatalyst in a Two-Phase System 253\u003c\/p\u003e \u003cp\u003e9.2 Preparative-scale Production of a Chiral, Bicyclic Proline Analog Intermediate for Boceprevir 257\u003c\/p\u003e \u003cp\u003e9.3 Focused Carbonyl Reductase Screening for Rapid Gram Supply of Highly Enantioenriched Secondary Alcohol Libraries 260\u003c\/p\u003e \u003cp\u003e9.4 A Rapid, Inexpensive and Colorimetric High-throughput Assay Format for Screening Commercial Ketoreductase Panels, Providing Indication of Substrate Scope, Co-factor Specificity and Enantioselectivity 266\u003c\/p\u003e \u003cp\u003e9.5 Stereoselective Production of (R)-3-quinuclidinol Using Recombinant Escherichia coli Whole Cells Overexpressing 3-Quinuclidinone Reductase and a Co-factor Regeneration System 273\u003c\/p\u003e \u003cp\u003e9.6 Preparation of N-Boc-D-Serine Using a Coupled D-Acylase\/Racemase Enzyme System 275\u003c\/p\u003e \u003cp\u003e9.7 Scale-up of a Biocatalytic Oxidase in a Dynamically Mixed Tubular Flow Reactor 279\u003c\/p\u003e \u003cp\u003eReferences 282\u003c\/p\u003e \u003cp\u003eIndex 285\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49528832885079,"sku":"9781118605257","price":106.35,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118605257.jpg?v=1731873198","url":"https:\/\/bookcurl.com\/products\/practical-methods-for-biocatalysis-and-biotransformations-volume-3-1-9781118605257","provider":"Book Curl","version":"1.0","type":"link"}