{"product_id":"polymers-in-regenerative-medicine-9780470596388","title":"Polymers in Regenerative Medicine","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eBiomedical applications of Polymers from Scaffolds to Nanostructures\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe ability of polymers to span wide ranges of mechanical properties and morph into desired shapes makes them useful for a variety of applications, including scaffolds, self-assembling materials, and nanomedicines. With an interdisciplinary list of subjects and contributors, this book overviews the biomedical applications of polymers and focuses on the aspect of regenerative medicine. Chapters also cover fundamentals, theories, and tools for scientists to apply polymers in the following ways:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eMatrix protein interactions with synthetic surfaces\u003c\/li\u003e \u003cli\u003eMethods and materials for cell scaffolds\u003c\/li\u003e \u003cli\u003eComplex cell-materials microenvironments in bioreactors\u003c\/li\u003e \u003cli\u003ePolymer therapeutics as nano-sized medicines for tissue repair\u003c\/li\u003e \u003cli\u003eFunctionalized mesoporous materials for controlled delivery\u003c\/li\u003e \u003cli\u003eNucleic acid delivery nanocarriers\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eConcepts include macro and nano requi\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003eContributors xvii\u003c\/p\u003e \u003cp\u003ePart A Methods for Synthetic Extracellular Matrices and Scaffolds 1\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Polymers as Materials for Tissue Engineering Scaffolds 3\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eAna Vallés Lluch Dunia Mercedes García Cruz Jorge Luis Escobar Ivirico Cristina Martínez Ramos and Manuel Monleón Pradas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 The Requirements Imposed by Application on Material Structures Intended as Tissue Engineering Scaffolds 3\u003c\/p\u003e \u003cp\u003e1.2 Composition and Function 5\u003c\/p\u003e \u003cp\u003e1.2.1 General Considerations 5\u003c\/p\u003e \u003cp\u003e1.2.2 Some Families of Polymers for Tissue Engineering Scaffolds 8\u003c\/p\u003e \u003cp\u003e1.2.3 Composite Scaffold Matrices 12\u003c\/p\u003e \u003cp\u003e1.3 Structure and Function 14\u003c\/p\u003e \u003cp\u003e1.3.1 General Considerations 14\u003c\/p\u003e \u003cp\u003e1.3.2 Structuring Polymer Matrices 15\u003c\/p\u003e \u003cp\u003e1.4 Properties of Scaffolds Relevant for Tissue Engineering Applications 24\u003c\/p\u003e \u003cp\u003e1.4.1 Porous Architecture 24\u003c\/p\u003e \u003cp\u003e1.4.2 Solid State Properties: Glass Transition Crystallinity 25\u003c\/p\u003e \u003cp\u003e1.4.3 Mechanical and Structural Properties 26\u003c\/p\u003e \u003cp\u003e1.4.4 Swelling Properties 28\u003c\/p\u003e \u003cp\u003e1.4.5 Degradation Properties 29\u003c\/p\u003e \u003cp\u003e1.4.6 Diffusion and Permeation 30\u003c\/p\u003e \u003cp\u003e1.4.7 Surface Tension and Contact Angle 31\u003c\/p\u003e \u003cp\u003e1.4.8 Biological Properties 31\u003c\/p\u003e \u003cp\u003e1.5 Compound Multicomponent Constructs 32\u003c\/p\u003e \u003cp\u003e1.5.1 Scaffold-Cum-Gel Constructs 32\u003c\/p\u003e \u003cp\u003e1.5.2 Scaffolds and Membranes Containing Microparticles 34\u003c\/p\u003e \u003cp\u003e1.5.3 Other Multicomponent Scaffold Constructs 34\u003c\/p\u003e \u003cp\u003e1.6 Questions Arising from Manipulation and Final Use 35\u003c\/p\u003e \u003cp\u003e1.6.1 Sterilization 35\u003c\/p\u003e \u003cp\u003e1.6.2 Cell Seeding Cell Culture Analysis 36\u003c\/p\u003e \u003cp\u003e1.6.3 In the Surgeon’s Hands 37\u003c\/p\u003e \u003cp\u003eReferences 37\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Natural-Based and Stimuli-Responsive Polymers for Tissue Engineering and Regenerative Medicine 49\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMariana B. Oliveira and João F. Mano\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 49\u003c\/p\u003e \u003cp\u003e2.2 Natural Polymers and Their Application in TE \u0026amp; RM 52\u003c\/p\u003e \u003cp\u003e2.2.1 Polysaccharides 52\u003c\/p\u003e \u003cp\u003e2.2.2 Protein-Based Polymers 60\u003c\/p\u003e \u003cp\u003e2.2.3 Polyesters 65\u003c\/p\u003e \u003cp\u003e2.3 Natural Polymers in Stimuli-Responsive Systems 65\u003c\/p\u003e \u003cp\u003e2.3.1 pH-Sensitive Natural Polymers 67\u003c\/p\u003e \u003cp\u003e2.3.2 Temperature Sensitive Natural Polymers 67\u003c\/p\u003e \u003cp\u003e2.3.3 Natural Polymers Modified to Show Thermoresponsive Behavior—Modifying Responsive Polymers\u003cbr\u003e and Agents 71\u003c\/p\u003e \u003cp\u003e2.3.4 Light-Sensitive Polymers—Potential Use of Azobenzene\/α-Cyclodextrin Inclusion Complexes 72\u003c\/p\u003e \u003cp\u003e2.4 Conclusions 73\u003c\/p\u003e \u003cp\u003eReferences 74\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Matrix Proteins Interactions with Synthetic Surfaces 91\u003c\/b\u003e\u003cbr\u003e \u003ci\u003ePatricia Rico Marco Cantini George Altankov and Manuel Salmerón-Sánchez\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 91\u003c\/p\u003e \u003cp\u003e3.2 Protein Adsorption 92\u003c\/p\u003e \u003cp\u003e3.2.1 Cell Adhesion Proteins 93\u003c\/p\u003e \u003cp\u003e3.2.2 Experimental Techniques to Follow Protein Adsorption 94\u003c\/p\u003e \u003cp\u003e3.2.3 Effect of Surface Properties on Protein Adsorption 97\u003c\/p\u003e \u003cp\u003e3.3 Cell Adhesion 109\u003c\/p\u003e \u003cp\u003e3.3.1 Experimental Techniques to Characterize Cell Adhesion 112\u003c\/p\u003e \u003cp\u003e3.3.2 Cell Adhesion at Cell–Material Interface 115\u003c\/p\u003e \u003cp\u003e3.4 Remodeling of the Adsorbed Proteins 122\u003c\/p\u003e \u003cp\u003e3.4.1 Protein Reorganization and Secretion at the Cell–Material Interface 122\u003c\/p\u003e \u003cp\u003e3.4.2 Proteolytic Remodeling at Cell–Materials Interface 126\u003c\/p\u003e \u003cp\u003eReferences 128\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Focal Adhesion Kinase in Cell–Material Interactions 147\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eCristina González-García Manuel Salmerón-Sánchez and Andrés J. García\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 147\u003c\/p\u003e \u003cp\u003e4.2 Role of FAK in Cell Proliferation 149\u003c\/p\u003e \u003cp\u003e4.3 Role of FAK in Migratory and Mechanosensing Responses 150\u003c\/p\u003e \u003cp\u003e4.4 Role of FAK in the Generation of Adhesives Forces 152\u003c\/p\u003e \u003cp\u003e4.5 Influence of Material Surface Properties on FAK Signaling 156\u003c\/p\u003e \u003cp\u003e4.5.1 Effect of Mechanical Properties on FAK Signaling 156\u003c\/p\u003e \u003cp\u003e4.5.2 Effect of Surface Topography on FAK Signaling 160\u003c\/p\u003e \u003cp\u003e4.5.3 Effect of Surface Chemistry on FAK Signaling 163\u003c\/p\u003e \u003cp\u003e4.5.4 Effect of Surface Functionalization in FAK Expression 165\u003c\/p\u003e \u003cp\u003eReferences 168\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Complex Cell–Materials Microenvironments in Bioreactors 177\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eStergios C. Dermenoudis and Yannis F. Missirlis\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 177\u003c\/p\u003e \u003cp\u003e5.2 Cell–ECM Interactions 178\u003c\/p\u003e \u003cp\u003e5.2.1 ECM Chemistry 179\u003c\/p\u003e \u003cp\u003e5.2.2 ECM Topography 181\u003c\/p\u003e \u003cp\u003e5.2.3 ECM Mechanical Properties 183\u003c\/p\u003e \u003cp\u003e5.2.4 ECM 3D Structure 184\u003c\/p\u003e \u003cp\u003e5.2.5 ECM-Induced Mechanical Stimuli 186\u003c\/p\u003e \u003cp\u003e5.3 Cell–Nutrient Medium 187\u003c\/p\u003e \u003cp\u003e5.3.1 Composition and Volume-Related Phenomena 188\u003c\/p\u003e \u003cp\u003e5.3.2 Mechanical Stresses Induced by Nutrient Medium 191\u003c\/p\u003e \u003cp\u003e5.4 Other Aspects of Interaction 194\u003c\/p\u003e \u003cp\u003e5.4.1 Co-Culture Systems 195\u003c\/p\u003e \u003cp\u003e5.4.2 Material Interactions 196\u003c\/p\u003e \u003cp\u003e5.5 Conclusions 197\u003c\/p\u003e \u003cp\u003eReferences 197\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart B N anostructures for Tissue Engineering 207\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Self-Curing Systems for Regenerative Medicine 209\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJulio San Román Blanca Vázquez and María Rosa Aguilar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 209\u003c\/p\u003e \u003cp\u003e6.2 Self-Curing Systems for Hard Tissue Regeneration 210\u003c\/p\u003e \u003cp\u003e6.2.1 Antimicrobial Self-Curing Formulations 211\u003c\/p\u003e \u003cp\u003e6.2.2 Self-Curing Formulations for Osteoporotic Bone 214\u003c\/p\u003e \u003cp\u003e6.2.3 Antineoplastic Drug-Loaded Self-Curing Formulations 216\u003c\/p\u003e \u003cp\u003e6.2.4 Nonsteroidal Anti-Inflammatory Drug-Loaded Formulations 217\u003c\/p\u003e \u003cp\u003e6.2.5 Self-Curing Formulations with Biodegradable Components 218\u003c\/p\u003e \u003cp\u003e6.3 Self-Curing Hydrogels for Soft Tissue Regeneration 219\u003c\/p\u003e \u003cp\u003e6.3.1 Chemically Cross-Linked Hydrogels 220\u003c\/p\u003e \u003cp\u003e6.3.2 Chemically and Physically Cross-Linked Hydrogels 225\u003c\/p\u003e \u003cp\u003e6.4 Expectative and Future Directions 226\u003c\/p\u003e \u003cp\u003eReferences 226\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Self-Assembling Peptides as Synthetic Extracellular Matrices 235\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eM.T. Fernandez Muiños and C.E. Semino\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 235\u003c\/p\u003e \u003cp\u003e7.2 In Vitro Applications 238\u003c\/p\u003e \u003cp\u003e7.3 In Vivo Applications 242\u003c\/p\u003e \u003cp\u003eReferences 245\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Polymer Therapeutics as Nano-Sized Medicines for Tissue Regeneration and Repair 249\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eAna Armiñán Pilar Sepúlveda and María J. Vicent\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Polymer Therapeutics as Nano-Sized Medicines 249\u003c\/p\u003e \u003cp\u003e8.1.1 The Concept and Biological Rationale behind Polymer Therapeutics 249\u003c\/p\u003e \u003cp\u003e8.1.2 Current Status and Future Trends 252\u003c\/p\u003e \u003cp\u003e8.2 Polymer Therapeutics for Tissue Regeneration and Repair 254\u003c\/p\u003e \u003cp\u003e8.2.1 Ischemia\/Reperfusion Injuries 255\u003c\/p\u003e \u003cp\u003e8.2.2 Wound Healing\/Repair 260\u003c\/p\u003e \u003cp\u003e8.2.3 Musculoskeletal Disorders 263\u003c\/p\u003e \u003cp\u003e8.2.4 Diseases of the Central Nervous System 267\u003c\/p\u003e \u003cp\u003e8.3 Conclusions and Future Perspectives 272\u003c\/p\u003e \u003cp\u003eReferences 273\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 How Regenerative Medicine Can Benefit from Nucleic Acids Delivery Nanocarriers? 285\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eErea Borrajo Anxo Vidal Maria J. Alonso and Marcos Garcia-Fuentes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 285\u003c\/p\u003e \u003cp\u003e9.1.1 Learning from Viruses: How to Overcome Cellular Barriers 286\u003c\/p\u003e \u003cp\u003e9.2 Nanotechnology in Gene Delivery 292\u003c\/p\u003e \u003cp\u003e9.2.1 Lipid Nanocarriers 292\u003c\/p\u003e \u003cp\u003e9.2.2 Polymeric Nanocarriers 294\u003c\/p\u003e \u003cp\u003e9.2.3 Inorganic Nanoparticles 300\u003c\/p\u003e \u003cp\u003e9.3 Nanotechnology in Regenerative Medicine 302\u003c\/p\u003e \u003cp\u003e9.3.1 Bone Regeneration 303\u003c\/p\u003e \u003cp\u003e9.3.2 Cartilage Regeneration 305\u003c\/p\u003e \u003cp\u003e9.3.3 Tendon Regeneration 308\u003c\/p\u003e \u003cp\u003e9.3.4 Myocardium Regeneration 309\u003c\/p\u003e \u003cp\u003e9.3.5 Neurological Tissue 311\u003c\/p\u003e \u003cp\u003e9.4 Conclusions 313\u003c\/p\u003e \u003cp\u003eReferences 313\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Functionalized Mesoporous Materials with Gate-Like Scaffoldings for Controlled Delivery 337\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eElena Aznar Estela Climent Laura Mondragon Félix Sancenón and Ramón Martínez-Máñez\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 337\u003c\/p\u003e \u003cp\u003e10.2 Mesoporous Silica Materials with Gate-Like Scaffoldings 339\u003c\/p\u003e \u003cp\u003e10.2.1 Controlled Delivery by pH Changes 339\u003c\/p\u003e \u003cp\u003e10.2.2 Controlled Delivery Using Redox Reactions 345\u003c\/p\u003e \u003cp\u003e10.2.3 Controlled Delivery Using Photochemical Reactions 349\u003c\/p\u003e \u003cp\u003e10.2.4 Controlled Delivery via Temperature Changes 352\u003c\/p\u003e \u003cp\u003e10.2.5 Controlled Delivery Using Small Molecules 355\u003c\/p\u003e \u003cp\u003e10.2.6 Controlled Delivery Using Biomolecules 356\u003c\/p\u003e \u003cp\u003e10.3 Concluding Remarks 360\u003c\/p\u003e \u003cp\u003eReferences 361\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Where Are We Going? Future Trends and Challenges 367\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eSang Jin Lee and Anthony Atala\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 367\u003c\/p\u003e \u003cp\u003e11.2 Classification of Biomaterials in Tissue Engineering and Regenerative Medicine 368\u003c\/p\u003e \u003cp\u003e11.2.1 N aturally Derived Materials 368\u003c\/p\u003e \u003cp\u003e11.2.2 Biodegradable Synthetic Polymers 370\u003c\/p\u003e \u003cp\u003e11.2.3 Tissue Matrices 372\u003c\/p\u003e \u003cp\u003e11.3 Basic Principles of Biomaterials in Tissue Engineering 373\u003c\/p\u003e \u003cp\u003e11.4 Development of Smart Biomaterials 374\u003c\/p\u003e \u003cp\u003e11.5 Scaffold Fabrication Technologies 376\u003c\/p\u003e \u003cp\u003e11.5.1 Injectable Hydrogels 376\u003c\/p\u003e \u003cp\u003e11.5.2 Electrospinning 377\u003c\/p\u003e \u003cp\u003e11.5.3 Computer-Aided Scaffold Fabrication 378\u003c\/p\u003e \u003cp\u003e11.5.4 Functionalization of Tissue-Engineered Biomaterial Scaffolds 379\u003c\/p\u003e \u003cp\u003e11.6 Summary and Future Directions 381\u003c\/p\u003e \u003cp\u003eReferences 384\u003c\/p\u003e \u003cp\u003eIndex 391\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402373472599,"sku":"9780470596388","price":116.85,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470596388.jpg?v=1730480204","url":"https:\/\/bookcurl.com\/products\/polymers-in-regenerative-medicine-9780470596388","provider":"Book Curl","version":"1.0","type":"link"}