{"product_id":"platelet-proteomics-9780470463376","title":"Platelet Proteomics","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThe purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics. This chapter shows potential applications for platelet proteomics not yet carried out. It includes examples of post-translational modifications (PTMs) analysis in platelets.  \u003cp\u003eThe second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome\/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease. This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, sys\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\"Experienced researchers looking for an up-to-date and comprehensive review of this rapidly developing field will find this book a valuable resource.”  (\u003ci\u003eAmerican Society for Mass Spectrometry\u003c\/i\u003e, 13 December 2011)\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eForeword xiii\u003c\/p\u003e \u003cp\u003ePreface xv\u003c\/p\u003e \u003cp\u003eAcronyms xvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I General Overview: Platelets, Sample Preparation, and Mass Spectrometry-Based Proteomics\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Platelets and Their Role in Thrombotic and Cardiovascular Disease: The Impact of Proteomic Analysis 3\u003cbr\u003e \u003ci\u003eRonald G. Stanley, Katherine L. Tucker, Natasha E. Barrett, and Jonathan M. Gibbins\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Mass-Spectrometry-Based Proteomics: General Overview and Posttranslational Modification Analysis in the Context of Platelet Research 27\u003cbr\u003e \u003ci\u003eJulia Maria Burkhart and Albert Sickmann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Sample Preparation Variables in Platelet Proteomics for Biomarker Research 67\u003cbr\u003e \u003ci\u003eMaria Zellner and Rudolf Oehler\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Analysis of The Platelet Proteome: Global Approaches and Subproteomes\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4 Two-Dimensional Gel Electrophoresis: Basic Principles and Application to Platelet Signaling Studies 89\u003cbr\u003e \u003ci\u003eÁngel Garc\u003c\/i\u003e\u003ci\u003eía\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 The Platelet Membrane Proteome 111\u003cbr\u003e \u003ci\u003eYotis A. Senis\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Proteomics of Platelet Granules, Organelles, and Releasate 139\u003cbr\u003e \u003ci\u003eJames P. McRedmond\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 The Platelet Microparticle Proteome 159\u003cbr\u003e \u003ci\u003eDavid M. Smalley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 \u003ci\u003eN\u003c\/i\u003e-Terminal Combined Fractional Diagonal Chromatographic (COFRADIC) Analysis of the Human Platelet Proteome 185\u003cbr\u003e \u003ci\u003eFrancis Impens, Kenny Helsens, Niklaas Colaert, Lennart Martens, Jo\u003c\/i\u003e\u003ci\u003eël Vandekerckhove, and Kris Gevaert\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III Integrated “Omics” and Application to Disease\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9 Serial Analysis of Gene Expression (SAGE) For Studying the Platelet and Megakaryocyte Transcriptome 209\u003cbr\u003e \u003ci\u003eMichael G. Tomlinson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 The Application of Microarray Analysis and Its Integration with Proteomics for Study of Platelet-Associated Disorders 231\u003cbr\u003e \u003ci\u003eDmitri V. Gnatenko and Wadie F. Bahou\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Platelet Functional Genomics 253\u003cbr\u003e \u003ci\u003eIsabelle I. Salles, Marie N. O’Connor, Daphne C. Thijssen-Timmer, Katleen Broos, and Hans Deckmyn\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Systems Biology to Study Platelet-Related Bleeding Disorders 285\u003cbr\u003e \u003ci\u003eJan-Willem N. Akkerman and Bernard De Bono\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Platelet Proteomics in Transfusion Medicine 321\u003cbr\u003e \u003ci\u003eThomas Thiele, Leif Steil, Uwe V\u003c\/i\u003e\u003ci\u003eölker, and Andreas Greinacher\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Cardiovascular Proteomics 341\u003cbr\u003e \u003ci\u003eFernando Vivanco, Fernando de la Cuesta, Maria G. Barderas, Irene Zubiri, and Gloria Álvarez-Llamas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 381\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49402338246999,"sku":"9780470463376","price":90.86,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780470463376.jpg?v=1730480109","url":"https:\/\/bookcurl.com\/products\/platelet-proteomics-9780470463376","provider":"Book Curl","version":"1.0","type":"link"}