{"product_id":"physiological-control-systems-9781119055334","title":"Physiological Control Systems","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eA guide to common control principles and how they are used to characterize a variety of physiological mechanisms\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe second edition of\u003ci\u003e Physiological Control Systems\u003c\/i\u003e offers an updated and comprehensive resource that reviews the fundamental concepts of classical control theory and how engineering methodology can be applied to obtain a quantitative understanding of physiological systems. The revised text also contains more advanced topics that feature applications to physiology of nonlinear dynamics, parameter estimation methods, and adaptive estimation and control. The authora noted expert in the fieldincludes a wealth of worked examples that illustrate key concepts and methodology and offers in-depth analyses of selected physiological control models that highlight the topics presented.\u003c\/p\u003e \u003cp\u003eThe author discusses the most noteworthy developments in system identification, optimal control, and nonlinear dynamical analysis and targets recent bioengineering advances.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003ePreface xiii\u003c\/p\u003e \u003cp\u003eAbout the Companion Website xvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Preliminary Considerations, 1\u003c\/p\u003e \u003cp\u003e1.2 Historical Background, 2\u003c\/p\u003e \u003cp\u003e1.3 Systems Analysis: Fundamental Concepts, 4\u003c\/p\u003e \u003cp\u003e1.4 Physiological Control Systems Analysis: A Simple Example, 6\u003c\/p\u003e \u003cp\u003e1.5 Differences Between Engineering and Physiological Control Systems, 8\u003c\/p\u003e \u003cp\u003e1.6 The Science (and Art) of Modeling, 11\u003c\/p\u003e \u003cp\u003e1.7 “Systems Physiology” Versus “Systems Biology”, 12\u003c\/p\u003e \u003cp\u003eProblems, 13\u003c\/p\u003e \u003cp\u003eBibliography, 15\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Mathematical Modeling 17\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Generalized System Properties, 17\u003c\/p\u003e \u003cp\u003e2.2 Models with Combinations of System Elements, 21\u003c\/p\u003e \u003cp\u003e2.3 Linear Models of Physiological Systems: Two Examples, 24\u003c\/p\u003e \u003cp\u003e2.4 Conversions Between Electrical and Mechanical Analogs, 27\u003c\/p\u003e \u003cp\u003e2.5 Distributed-Parameter Versus Lumped-Parameter Models, 29\u003c\/p\u003e \u003cp\u003e2.6 Linear Systems and the Superposition Principle, 31\u003c\/p\u003e \u003cp\u003e2.7 Zero-Input and Zero-State Solutions of ODEs, 33\u003c\/p\u003e \u003cp\u003e2.8 Laplace Transforms and Transfer Functions, 34\u003c\/p\u003e \u003cp\u003e2.8.1 Solving ODEs with Laplace Transforms, 36\u003c\/p\u003e \u003cp\u003e2.9 The Impulse Response and Linear Convolution, 38\u003c\/p\u003e \u003cp\u003e2.10 State-Space Analysis, 40\u003c\/p\u003e \u003cp\u003e2.11 Computer Analysis and Simulation: MATLAB and SIMULINK, 43\u003c\/p\u003e \u003cp\u003eProblems, 49\u003c\/p\u003e \u003cp\u003eBibliography, 53\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Static Analysis of Physiological Systems 55\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction, 55\u003c\/p\u003e \u003cp\u003e3.2 Open-Loop Versus Closed-Loop Systems, 56\u003c\/p\u003e \u003cp\u003e3.3 Determination of the Steady-State Operating Point, 59\u003c\/p\u003e \u003cp\u003e3.4 Steady-State Analysis Using SIMULINK, 63\u003c\/p\u003e \u003cp\u003e3.5 Regulation of Cardiac Output, 66\u003c\/p\u003e \u003cp\u003e3.5.1 The Cardiac Output Curve, 67\u003c\/p\u003e \u003cp\u003e3.5.2 The Venous Return Curve, 69\u003c\/p\u003e \u003cp\u003e3.5.3 Closed-Loop Analysis: Heart and Systemic Circulation Combined, 73\u003c\/p\u003e \u003cp\u003e3.6 Regulation of Glucose Insulin, 74\u003c\/p\u003e \u003cp\u003e3.7 Chemical Regulation of Ventilation, 78\u003c\/p\u003e \u003cp\u003e3.7.1 The Gas Exchanger, 80\u003c\/p\u003e \u003cp\u003e3.7.2 The Respiratory Controller, 82\u003c\/p\u003e \u003cp\u003e3.7.3 Closed-Loop Analysis: Lungs and Controller Combined, 82\u003c\/p\u003e \u003cp\u003eProblems, 86\u003c\/p\u003e \u003cp\u003eBibliography, 91\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Time-Domain Analysis of Linear Control Systems 93\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Linearized Respiratory Mechanics: Open-Loop Versus Closed-Loop, 93\u003c\/p\u003e \u003cp\u003e4.2 Open-Loop Versus Closed-Loop Transient Responses: First-Order Model, 96\u003c\/p\u003e \u003cp\u003e4.2.1 Impulse Response, 96\u003c\/p\u003e \u003cp\u003e4.2.2 Step Response, 97\u003c\/p\u003e \u003cp\u003e4.3 Open-Loop Versus Closed-Loop Transient Responses: Second-Order Model, 98\u003c\/p\u003e \u003cp\u003e4.3.1 Impulse Responses, 98\u003c\/p\u003e \u003cp\u003e4.3.2 Step Responses, 103\u003c\/p\u003e \u003cp\u003e4.4 Descriptors of Impulse and Step Responses, 107\u003c\/p\u003e \u003cp\u003e4.4.1 Generalized Second-Order Dynamics, 107\u003c\/p\u003e \u003cp\u003e4.4.2 Transient Response Descriptors, 111\u003c\/p\u003e \u003cp\u003e4.5 Open-Loop Versus Closed-Loop Dynamics: Other Considerations, 114\u003c\/p\u003e \u003cp\u003e4.5.1 Reduction of the Effects of External Disturbances, 114\u003c\/p\u003e \u003cp\u003e4.5.2 Reduction of the Effects of Parameter Variations, 115\u003c\/p\u003e \u003cp\u003e4.5.3 Integral Control, 116\u003c\/p\u003e \u003cp\u003e4.5.4 Derivative Feedback, 118\u003c\/p\u003e \u003cp\u003e4.5.5 Minimizing Effect of External Disturbances by Feedforward Gain, 119\u003c\/p\u003e \u003cp\u003e4.6 Transient Response Analysis Using MATLAB, 121\u003c\/p\u003e \u003cp\u003e4.7 SIMULINK Application 1: Dynamics of Neuromuscular Reflex Motion, 122\u003c\/p\u003e \u003cp\u003e4.7.1 A Model of Neuromuscular Reflex Motion, 122\u003c\/p\u003e \u003cp\u003e4.7.2 SIMULINK Implementation, 126\u003c\/p\u003e \u003cp\u003e4.8 SIMULINK Application 2: Dynamics of Glucose–Insulin Regulation, 127\u003c\/p\u003e \u003cp\u003e4.8.1 The Model, 127\u003c\/p\u003e \u003cp\u003e4.8.2 Simulations with the Model, 131\u003c\/p\u003e \u003cp\u003eProblems, 131\u003c\/p\u003e \u003cp\u003eBibliography, 135\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Frequency-Domain Analysis of Linear Control Systems 137\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Steady-State Responses to Sinusoidal Inputs, 137\u003c\/p\u003e \u003cp\u003e5.1.1 Open-Loop Frequency Response, 137\u003c\/p\u003e \u003cp\u003e5.1.2 Closed-Loop Frequency Response, 141\u003c\/p\u003e \u003cp\u003e5.1.3 Relationship between Transient and Frequency Responses, 143\u003c\/p\u003e \u003cp\u003e5.2 Graphical Representations of Frequency Response, 145\u003c\/p\u003e \u003cp\u003e5.2.1 Bode Plot Representation, 145\u003c\/p\u003e \u003cp\u003e5.2.2 Nichols Charts, 147\u003c\/p\u003e \u003cp\u003e5.2.3 Nyquist Plots, 148\u003c\/p\u003e \u003cp\u003e5.3 Frequency-Domain Analysis Using MATLAB and SIMULINK, 152\u003c\/p\u003e \u003cp\u003e5.3.1 Using MATLAB, 152\u003c\/p\u003e \u003cp\u003e5.3.2 Using SIMULINK, 154\u003c\/p\u003e \u003cp\u003e5.4 Estimation of Frequency Response from Input–Output Data, 156\u003c\/p\u003e \u003cp\u003e5.4.1 Underlying Principles, 156\u003c\/p\u003e \u003cp\u003e5.4.2 Physiological Application: Forced Oscillation Technique in Respiratory Mechanics, 157\u003c\/p\u003e \u003cp\u003e5.5 Frequency Response of a Model of Circulatory Control, 159\u003c\/p\u003e \u003cp\u003e5.5.1 The Model, 159\u003c\/p\u003e \u003cp\u003e5.5.2 Simulations with the Model, 160\u003c\/p\u003e \u003cp\u003e5.5.3 Frequency Response of the Model, 162\u003c\/p\u003e \u003cp\u003eProblems, 164\u003c\/p\u003e \u003cp\u003eBibliography, 165\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Stability Analysis: Linear Approaches 167\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Stability and Transient Response, 167\u003c\/p\u003e \u003cp\u003e6.2 Root Locus Plots, 170\u003c\/p\u003e \u003cp\u003e6.3 Routh–Hurwitz Stability Criterion, 174\u003c\/p\u003e \u003cp\u003e6.4 Nyquist Criterion for Stability, 176\u003c\/p\u003e \u003cp\u003e6.5 Relative Stability, 181\u003c\/p\u003e \u003cp\u003e6.6 Stability Analysis of the Pupillary Light Reflex, 184\u003c\/p\u003e \u003cp\u003e6.6.1 Routh–Hurwitz Analysis, 186\u003c\/p\u003e \u003cp\u003e6.6.2 Nyquist Analysis, 187\u003c\/p\u003e \u003cp\u003e6.7 Model of Cheyne–Stokes Breathing, 190\u003c\/p\u003e \u003cp\u003e6.7.1 CO\u003csub\u003e2\u003c\/sub\u003e Exchange in the Lungs, 190\u003c\/p\u003e \u003cp\u003e6.7.2 Transport Delays, 192\u003c\/p\u003e \u003cp\u003e6.7.3 Controller Responses, 193\u003c\/p\u003e \u003cp\u003e6.7.4 Loop Transfer Functions, 193\u003c\/p\u003e \u003cp\u003e6.7.5 Nyquist Stability Analysis Using MATLAB, 194\u003c\/p\u003e \u003cp\u003eProblems, 196\u003c\/p\u003e \u003cp\u003eBibliography, 198\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Digital Simulation of Continuous-Time Systems 199\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Preliminary Considerations: Sampling and the Z-Transform, 199\u003c\/p\u003e \u003cp\u003e7.2 Methods for Continuous-Time to Discrete-Time Conversion, 202\u003c\/p\u003e \u003cp\u003e7.2.1 Impulse Invariance, 202\u003c\/p\u003e \u003cp\u003e7.2.2 Forward Difference, 203\u003c\/p\u003e \u003cp\u003e7.2.3 Backward Difference, 204\u003c\/p\u003e \u003cp\u003e7.2.4 Bilinear Transformation, 205\u003c\/p\u003e \u003cp\u003e7.3 Sampling, 207\u003c\/p\u003e \u003cp\u003e7.4 Digital Simulation: Stability and Performance Considerations, 211\u003c\/p\u003e \u003cp\u003e7.5 Physiological Application: The Integral Pulse Frequency Modulation Model, 216\u003c\/p\u003e \u003cp\u003eProblems, 221\u003c\/p\u003e \u003cp\u003eBibliography, 224\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Model Identification and Parameter Estimation 225\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Basic Problems in Physiological System Analysis, 225\u003c\/p\u003e \u003cp\u003e8.2 Nonparametric and Parametric Identification Methods, 228\u003c\/p\u003e \u003cp\u003e8.2.1 Numerical Deconvolution, 228\u003c\/p\u003e \u003cp\u003e8.2.2 Least-Squares Estimation, 230\u003c\/p\u003e \u003cp\u003e8.2.3 Estimation Using Correlation Functions, 233\u003c\/p\u003e \u003cp\u003e8.2.4 Estimation in the Frequency Domain, 235\u003c\/p\u003e \u003cp\u003e8.2.5 Optimization Techniques, 237\u003c\/p\u003e \u003cp\u003e8.3 Problems in Parameter Estimation: Identifiability and Input Design, 243\u003c\/p\u003e \u003cp\u003e8.3.1 Structural Identifiability, 243\u003c\/p\u003e \u003cp\u003e8.3.2 Sensitivity Analysis, 244\u003c\/p\u003e \u003cp\u003e8.3.3 Input Design, 248\u003c\/p\u003e \u003cp\u003e8.4 Identification of Closed-Loop Systems: “Opening the Loop”, 252\u003c\/p\u003e \u003cp\u003e8.4.1 The Starling Heart–Lung Preparation, 253\u003c\/p\u003e \u003cp\u003e8.4.2 Kao’s Cross-Circulation Experiments, 253\u003c\/p\u003e \u003cp\u003e8.4.3 Artificial Brain Perfusion for Partitioning Central and Peripheral Chemoreflexes, 255\u003c\/p\u003e \u003cp\u003e8.4.4 The Voltage Clamp, 256\u003c\/p\u003e \u003cp\u003e8.4.5 Opening the Pupillary Reflex Loop, 257\u003c\/p\u003e \u003cp\u003e8.4.6 Read Rebreathing Technique, 259\u003c\/p\u003e \u003cp\u003e8.5 Identification Under Closed-Loop Conditions: Case Studies, 260\u003c\/p\u003e \u003cp\u003e8.5.1 Minimal Model of Blood Glucose Regulation, 262\u003c\/p\u003e \u003cp\u003e8.5.2 Closed-Loop Identification of the Respiratory Control System, 267\u003c\/p\u003e \u003cp\u003e8.5.3 Closed-Loop Identification of Autonomic Control Using Multivariate ARX Models, 273\u003c\/p\u003e \u003cp\u003e8.6 Identification of Physiological Systems Using Basis Functions, 276\u003c\/p\u003e \u003cp\u003e8.6.1 Reducing Variance in the Parameter Estimates, 276\u003c\/p\u003e \u003cp\u003e8.6.2 Use of Basis Functions, 277\u003c\/p\u003e \u003cp\u003e8.6.3 Baroreflex and Respiratory Modulation of Heart Rate Variability, 279\u003c\/p\u003e \u003cp\u003eProblems, 283\u003c\/p\u003e \u003cp\u003eBibliography, 285\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Estimation and Control of Time-Varying Systems 289\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Modeling Time-Varying Systems: Key Concepts, 289\u003c\/p\u003e \u003cp\u003e9.2 Estimation of Models with Time-Varying Parameters, 293\u003c\/p\u003e \u003cp\u003e9.2.1 Optimal Estimation: The Wiener Filter, 293\u003c\/p\u003e \u003cp\u003e9.2.2 Adaptive Estimation: The LMS Algorithm, 294\u003c\/p\u003e \u003cp\u003e9.2.3 Adaptive Estimation: The RLS Algorithm, 296\u003c\/p\u003e \u003cp\u003e9.3 Estimation of Time-Varying Physiological Models, 300\u003c\/p\u003e \u003cp\u003e9.3.1 Extending Adaptive Estimation Algorithms to Other Model Structures, 300\u003c\/p\u003e \u003cp\u003e9.3.2 Adaptive Estimation of Pulmonary Gas Exchange, 300\u003c\/p\u003e \u003cp\u003e9.3.3 Quantifying Transient Changes in Autonomic Cardiovascular Control, 304\u003c\/p\u003e \u003cp\u003e9.4 Adaptive Control of Physiological Systems, 307\u003c\/p\u003e \u003cp\u003e9.4.1 General Considerations, 307\u003c\/p\u003e \u003cp\u003e9.4.2 Adaptive Buffering of Fluctuations in Arterial PCO\u003csub\u003e2\u003c\/sub\u003e, 308\u003c\/p\u003e \u003cp\u003eProblems, 313\u003c\/p\u003e \u003cp\u003eBibliography, 314\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Nonlinear Analysis of Physiological Control Systems 317\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Nonlinear Versus Linear Closed-Loop Systems, 317\u003c\/p\u003e \u003cp\u003e10.2 Phase-Plane Analysis, 320\u003c\/p\u003e \u003cp\u003e10.2.1 Local Stability: Singular Points, 322\u003c\/p\u003e \u003cp\u003e10.2.2 Method of Isoclines, 325\u003c\/p\u003e \u003cp\u003e10.3 Nonlinear Oscillators, 329\u003c\/p\u003e \u003cp\u003e10.3.1 Limit Cycles, 329\u003c\/p\u003e \u003cp\u003e10.3.2 The van der Pol Oscillator, 329\u003c\/p\u003e \u003cp\u003e10.3.3 Modeling Cardiac Dysrhythmias, 336\u003c\/p\u003e \u003cp\u003e10.4 The Describing Function Method, 342\u003c\/p\u003e \u003cp\u003e10.4.1 Methodology, 342\u003c\/p\u003e \u003cp\u003e10.4.2 Application: Periodic Breathing with Apnea, 345\u003c\/p\u003e \u003cp\u003e10.5 Models of Neuronal Dynamics, 348\u003c\/p\u003e \u003cp\u003e10.5.1 The Hodgkin–Huxley Model, 349\u003c\/p\u003e \u003cp\u003e10.5.2 The Bonhoeffer–van der Pol Model, 352\u003c\/p\u003e \u003cp\u003e10.6 Nonparametric Identification of Nonlinear Systems, 359\u003c\/p\u003e \u003cp\u003e10.6.1 Volterra–Wiener Kernel Approach, 360\u003c\/p\u003e \u003cp\u003e10.6.2 Nonlinear Model of Baroreflex and Respiratory Modulated Heart Rate, 364\u003c\/p\u003e \u003cp\u003e10.6.3 Interpretations of Kernels, 367\u003c\/p\u003e \u003cp\u003e10.6.4 Higher Order Nonlinearities and Block-Structured Models, 369\u003c\/p\u003e \u003cp\u003eProblems, 370\u003c\/p\u003e \u003cp\u003eBibliography, 374\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Complex Dynamics in Physiological Control Systems 377\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Spontaneous Variability, 377\u003c\/p\u003e \u003cp\u003e11.2 Nonlinear Control Systems with Delayed Feedback, 380\u003c\/p\u003e \u003cp\u003e11.2.1 The Logistic Equation, 380\u003c\/p\u003e \u003cp\u003e11.2.2 Regulation of Neutrophil Density, 384\u003c\/p\u003e \u003cp\u003e11.2.3 Model of Cardiovascular Variability, 387\u003c\/p\u003e \u003cp\u003e11.3 Coupled Nonlinear Oscillators: Model of Circadian Rhythms, 397\u003c\/p\u003e \u003cp\u003e11.4 Time-Varying Physiological Closed-Loop Systems: Sleep Apnea Model, 401\u003c\/p\u003e \u003cp\u003e11.5 Propagation of System Noise in Feedback Loops, 409\u003c\/p\u003e \u003cp\u003eProblems, 415\u003c\/p\u003e \u003cp\u003eBibliography, 416\u003c\/p\u003e \u003cp\u003eAppendix A Commonly Used Laplace Transform Pairs 419\u003c\/p\u003e \u003cp\u003eAppendix B List of MATLAB and SIMULINK Programs 421\u003c\/p\u003e \u003cp\u003eIndex 425\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49406975279447,"sku":"9781119055334","price":98.96,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781119055334.jpg?v=1730497755","url":"https:\/\/bookcurl.com\/products\/physiological-control-systems-9781119055334","provider":"Book Curl","version":"1.0","type":"link"}