{"product_id":"physical-chemistry-for-the-biological-sciences-9781118859001","title":"Physical Chemistry for the Biological Sciences","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eThis book provides an introduction to physical chemistry that is directed toward applications to the biological sciences. Advanced mathematics is not required. This book can be used for either a one semester or two semester course, and as a reference volume by students and faculty in the biological sciences.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003ePreface to First Edition xv\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePreface to Second Edition xvii\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eTHERMODYNAMICS 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1. Heat, Work, and Energy 3\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 3\u003c\/p\u003e \u003cp\u003e1.2 Temperature 4\u003c\/p\u003e \u003cp\u003e1.3 Heat 5\u003c\/p\u003e \u003cp\u003e1.4 Work 6\u003c\/p\u003e \u003cp\u003e1.5 Definition of Energy 9\u003c\/p\u003e \u003cp\u003e1.6 Enthalpy 11\u003c\/p\u003e \u003cp\u003e1.7 Standard States 12\u003c\/p\u003e \u003cp\u003e1.8 Calorimetry 13\u003c\/p\u003e \u003cp\u003e1.9 Reaction Enthalpies 16\u003c\/p\u003e \u003cp\u003e1.10 Temperature Dependence of the Reaction Enthalpy 18\u003c\/p\u003e \u003cp\u003eReferences 19\u003c\/p\u003e \u003cp\u003eProblems 20\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2. Entropy and Gibbs Energy 23\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 23\u003c\/p\u003e \u003cp\u003e2.2 Statement of the Second Law 24\u003c\/p\u003e \u003cp\u003e2.3 Calculation of the Entropy 26\u003c\/p\u003e \u003cp\u003e2.4 Third Law of Thermodynamics 28\u003c\/p\u003e \u003cp\u003e2.5 Molecular Interpretation of Entropy 29\u003c\/p\u003e \u003cp\u003e2.6 Gibbs Energy 30\u003c\/p\u003e \u003cp\u003e2.7 Chemical Equilibria 32\u003c\/p\u003e \u003cp\u003e2.8 Pressure and Temperature Dependence of the Gibbs Energy 35\u003c\/p\u003e \u003cp\u003e2.9 Phase Changes 36\u003c\/p\u003e \u003cp\u003e2.10 Additions to the Gibbs Energy 39\u003c\/p\u003e \u003cp\u003eProblems 40\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3. Applications of Thermodynamics to Biological Systems 43\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Biochemical Reactions 43\u003c\/p\u003e \u003cp\u003e3.2 Metabolic Cycles 45\u003c\/p\u003e \u003cp\u003e3.3 Direct Synthesis of ATP 49\u003c\/p\u003e \u003cp\u003e3.4 Establishment of Membrane Ion Gradients by Chemical Reactions 51\u003c\/p\u003e \u003cp\u003e3.5 Protein Structure 52\u003c\/p\u003e \u003cp\u003e3.6 Protein Folding 60\u003c\/p\u003e \u003cp\u003e3.7 Nucleic Acid Structures 63\u003c\/p\u003e \u003cp\u003e3.8 DNA Melting 67\u003c\/p\u003e \u003cp\u003e3.9 RNA 71\u003c\/p\u003e \u003cp\u003eReferences 72\u003c\/p\u003e \u003cp\u003eProblems 73\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4. Thermodynamics Revisited 77\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 77\u003c\/p\u003e \u003cp\u003e4.2 Mathematical Tools 77\u003c\/p\u003e \u003cp\u003e4.3 Maxwell Relations 78\u003c\/p\u003e \u003cp\u003e4.4 Chemical Potential 80\u003c\/p\u003e \u003cp\u003e4.5 Partial Molar Quantities 83\u003c\/p\u003e \u003cp\u003e4.6 Osmotic Pressure 85\u003c\/p\u003e \u003cp\u003e4.7 Chemical Equilibria 87\u003c\/p\u003e \u003cp\u003e4.8 Ionic Solutions 89\u003c\/p\u003e \u003cp\u003eReferences 93\u003c\/p\u003e \u003cp\u003eProblems 93\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCHEMICAL KINETICS 95\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5. Principles of Chemical Kinetics 97\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 97\u003c\/p\u003e \u003cp\u003e5.2 Reaction Rates 99\u003c\/p\u003e \u003cp\u003e5.3 Determination of Rate Laws 101\u003c\/p\u003e \u003cp\u003e5.4 Radioactive Decay 104\u003c\/p\u003e \u003cp\u003e5.5 Reaction Mechanisms 105\u003c\/p\u003e \u003cp\u003e5.6 Temperature Dependence of Rate Constants 108\u003c\/p\u003e \u003cp\u003e5.7 Relationship Between Thermodynamics and Kinetics 112\u003c\/p\u003e \u003cp\u003e5.8 Reaction Rates Near Equilibrium 114\u003c\/p\u003e \u003cp\u003e5.9 Single Molecule Kinetics 116\u003c\/p\u003e \u003cp\u003eReferences 118\u003c\/p\u003e \u003cp\u003eProblems 118\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6. Applications of Kinetics to Biological Systems 121\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 121\u003c\/p\u003e \u003cp\u003e6.2 Enzyme Catalysis: The Michaelis–Menten Mechanism 121\u003c\/p\u003e \u003cp\u003e6.3 \u003ci\u003eα\u003c\/i\u003e-Chymotrypsin 126\u003c\/p\u003e \u003cp\u003e6.4 Protein Tyrosine Phosphatase 133\u003c\/p\u003e \u003cp\u003e6.5 Ribozymes 137\u003c\/p\u003e \u003cp\u003e6.6 DNA Melting and Renaturation 142\u003c\/p\u003e \u003cp\u003eReferences 148\u003c\/p\u003e \u003cp\u003eProblems 149\u003c\/p\u003e \u003cp\u003e\u003cb\u003eQUANTUM MECHANICS 153\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7. Fundamentals of Quantum Mechanics 155\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 155\u003c\/p\u003e \u003cp\u003e7.2 Schrödinger Equation 158\u003c\/p\u003e \u003cp\u003e7.3 Particle in a Box 159\u003c\/p\u003e \u003cp\u003e7.4 Vibrational Motions 162\u003c\/p\u003e \u003cp\u003e7.5 Tunneling 165\u003c\/p\u003e \u003cp\u003e7.6 Rotational Motions 167\u003c\/p\u003e \u003cp\u003e7.7 Basics of Spectroscopy 169\u003c\/p\u003e \u003cp\u003eReferences 173\u003c\/p\u003e \u003cp\u003eProblems 174\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8. Electronic Structure of Atoms and Molecules 177\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 177\u003c\/p\u003e \u003cp\u003e8.2 Hydrogenic Atoms 177\u003c\/p\u003e \u003cp\u003e8.3 Many-Electron Atoms 181\u003c\/p\u003e \u003cp\u003e8.4 Born–Oppenheimer Approximation 184\u003c\/p\u003e \u003cp\u003e8.5 Molecular Orbital Theory 186\u003c\/p\u003e \u003cp\u003e8.6 Hartree–Fock Theory and Beyond 190\u003c\/p\u003e \u003cp\u003e8.7 Density Functional Theory 193\u003c\/p\u003e \u003cp\u003e8.8 Quantum Chemistry of Biological Systems 194\u003c\/p\u003e \u003cp\u003eReferences 200\u003c\/p\u003e \u003cp\u003eProblems 201\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSPECTROSCOPY 203\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9. X-ray Crystallography 205\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 205\u003c\/p\u003e \u003cp\u003e9.2 Scattering of X-Rays by a Crystal 206\u003c\/p\u003e \u003cp\u003e9.3 Structure Determination 208\u003c\/p\u003e \u003cp\u003e9.4 Neutron Diffraction 212\u003c\/p\u003e \u003cp\u003e9.5 Nucleic Acid Structure 213\u003c\/p\u003e \u003cp\u003e9.6 Protein Structure 216\u003c\/p\u003e \u003cp\u003e9.7 Enzyme Catalysis 219\u003c\/p\u003e \u003cp\u003eReferences 222\u003c\/p\u003e \u003cp\u003eProblems 223\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10. Electronic Spectra 225\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 225\u003c\/p\u003e \u003cp\u003e10.2 Absorption Spectra 226\u003c\/p\u003e \u003cp\u003e10.3 Ultraviolet Spectra of Proteins 228\u003c\/p\u003e \u003cp\u003e10.4 Nucleic Acid Spectra 230\u003c\/p\u003e \u003cp\u003e10.5 Prosthetic Groups 231\u003c\/p\u003e \u003cp\u003e10.6 Difference Spectroscopy 233\u003c\/p\u003e \u003cp\u003e10.7 X-Ray Absorption Spectroscopy 236\u003c\/p\u003e \u003cp\u003e10.8 Fluorescence and Phosphorescence 236\u003c\/p\u003e \u003cp\u003e10.9 RecBCD: Helicase Activity Monitored by Fluorescence 240\u003c\/p\u003e \u003cp\u003e10.10 Fluorescence Energy Transfer: A Molecular Ruler 241\u003c\/p\u003e \u003cp\u003e10.11 Application of Energy Transfer to Biological Systems 243\u003c\/p\u003e \u003cp\u003e10.12 Dihydrofolate Reductase 245\u003c\/p\u003e \u003cp\u003eReferences 247\u003c\/p\u003e \u003cp\u003eProblems 248\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11. Circular Dichroism, Optical Rotary Dispersion, and Fluorescence Polarization 253\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 253\u003c\/p\u003e \u003cp\u003e11.2 Optical Rotary Dispersion 254\u003c\/p\u003e \u003cp\u003e11.3 Circular Dichroism 256\u003c\/p\u003e \u003cp\u003e11.4 Optical Rotary Dispersion and Circular Dichroism of Proteins 257\u003c\/p\u003e \u003cp\u003e11.5 Optical Rotation and Circular Dichroism of Nucleic Acids 259\u003c\/p\u003e \u003cp\u003e11.6 Small Molecule Binding to DNA 260\u003c\/p\u003e \u003cp\u003e11.7 Protein Folding 263\u003c\/p\u003e \u003cp\u003e11.8 Interaction of DNA with Zinc Finger Proteins 266\u003c\/p\u003e \u003cp\u003e11.9 Fluorescence Polarization 267\u003c\/p\u003e \u003cp\u003e11.10 Integration of HIV Genome Into Host Genome 269\u003c\/p\u003e \u003cp\u003e11.11 \u003ci\u003eα\u003c\/i\u003e-Ketoglutarate Dehydrogenase 270\u003c\/p\u003e \u003cp\u003eReferences 272\u003c\/p\u003e \u003cp\u003eProblems 273\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12. Vibrations in Macromolecules 277\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 277\u003c\/p\u003e \u003cp\u003e12.2 Infrared Spectroscopy 278\u003c\/p\u003e \u003cp\u003e12.3 Raman Spectroscopy 279\u003c\/p\u003e \u003cp\u003e12.4 Structure Determination with Vibrational Spectroscopy 281\u003c\/p\u003e \u003cp\u003e12.5 Resonance Raman Spectroscopy 283\u003c\/p\u003e \u003cp\u003e12.6 Structure of Enzyme–Substrate Complexes 286\u003c\/p\u003e \u003cp\u003e12.7 Conclusion 287\u003c\/p\u003e \u003cp\u003eReferences 287\u003c\/p\u003e \u003cp\u003eProblems 288\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13. Principles of Nuclear Magnetic Resonance and Electron Spin Resonance 289\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 289\u003c\/p\u003e \u003cp\u003e13.2 NMR Spectrometers 292\u003c\/p\u003e \u003cp\u003e13.3 Chemical Shifts 293\u003c\/p\u003e \u003cp\u003e13.4 Spin–Spin Splitting 296\u003c\/p\u003e \u003cp\u003e13.5 Relaxation Times 298\u003c\/p\u003e \u003cp\u003e13.6 Multidimensional NMR 300\u003c\/p\u003e \u003cp\u003e13.7 Magnetic Resonance Imaging 306\u003c\/p\u003e \u003cp\u003e13.8 Electron Spin Resonance 306\u003c\/p\u003e \u003cp\u003eReferences 310\u003c\/p\u003e \u003cp\u003eProblems 310\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14. Applications of Magnetic Resonance to Biology 315\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 315\u003c\/p\u003e \u003cp\u003e14.2 Regulation of DNA Transcription 315\u003c\/p\u003e \u003cp\u003e14.3 Protein–DNA Interactions 318\u003c\/p\u003e \u003cp\u003e14.4 Dynamics of Protein Folding 320\u003c\/p\u003e \u003cp\u003e14.5 RNA Folding 322\u003c\/p\u003e \u003cp\u003e14.6 Lactose Permease 325\u003c\/p\u003e \u003cp\u003e14.7 Proteasome Structure and Function 328\u003c\/p\u003e \u003cp\u003e14.8 Conclusion 329\u003c\/p\u003e \u003cp\u003eReferences 329\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSTATISTICAL MECHANICS 331\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15. Fundamentals of Statistical Mechanics 333\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction 333\u003c\/p\u003e \u003cp\u003e15.2 Kinetic Model of Gases 333\u003c\/p\u003e \u003cp\u003e15.3 Boltzmann Distribution 338\u003c\/p\u003e \u003cp\u003e15.4 Molecular Partition Function 343\u003c\/p\u003e \u003cp\u003e15.5 Ensembles 346\u003c\/p\u003e \u003cp\u003e15.6 Statistical Entropy 349\u003c\/p\u003e \u003cp\u003e15.7 Helix-Coil Transition 350\u003c\/p\u003e \u003cp\u003eReferences 353\u003c\/p\u003e \u003cp\u003eProblems 354\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16. Molecular Simulations 357\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction 357\u003c\/p\u003e \u003cp\u003e16.2 Potential Energy Surfaces 358\u003c\/p\u003e \u003cp\u003e16.3 Molecular Mechanics and Docking 364\u003c\/p\u003e \u003cp\u003e16.4 Large-Scale Simulations 365\u003c\/p\u003e \u003cp\u003e16.5 Molecular Dynamics 367\u003c\/p\u003e \u003cp\u003e16.6 Monte Carlo 373\u003c\/p\u003e \u003cp\u003e16.7 Hybrid Quantum\/Classical Methods 373\u003c\/p\u003e \u003cp\u003e16.8 Helmholtz and Gibbs Energy Calculations 375\u003c\/p\u003e \u003cp\u003e16.9 Simulations of Enzyme Reactions 376\u003c\/p\u003e \u003cp\u003eReferences 379\u003c\/p\u003e \u003cp\u003eProblems 379\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSPECIAL TOPICS 383\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17. Ligand Binding to Macromolecules 385\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e17.1 Introduction 385\u003c\/p\u003e \u003cp\u003e17.2 Binding of Small Molecules to Multiple Identical Binding Sites 385\u003c\/p\u003e \u003cp\u003e17.3 Macroscopic and Microscopic Equilibrium Constants 387\u003c\/p\u003e \u003cp\u003e17.4 Statistical Effects in Ligand Binding to Macromolecules 389\u003c\/p\u003e \u003cp\u003e17.5 Experimental Determination of Ligand Binding Isotherms 392\u003c\/p\u003e \u003cp\u003e17.6 Binding of Cro Repressor Protein to DNA 395\u003c\/p\u003e \u003cp\u003e17.7 Cooperativity in Ligand Binding 397\u003c\/p\u003e \u003cp\u003e17.8 Models for Cooperativity 402\u003c\/p\u003e \u003cp\u003e17.9 Kinetic Studies of Cooperative Binding 406\u003c\/p\u003e \u003cp\u003e17.10 Allosterism 408\u003c\/p\u003e \u003cp\u003eReferences 412\u003c\/p\u003e \u003cp\u003eProblems 412\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18. Hydrodynamics of Macromolecules 415\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e18.1 Introduction 415\u003c\/p\u003e \u003cp\u003e18.2 Frictional Coefficient 415\u003c\/p\u003e \u003cp\u003e18.3 Diffusion 418\u003c\/p\u003e \u003cp\u003e18.4 Centrifugation 421\u003c\/p\u003e \u003cp\u003e18.5 Velocity Sedimentation 422\u003c\/p\u003e \u003cp\u003e18.6 Equilibrium Centrifugation 424\u003c\/p\u003e \u003cp\u003e18.7 Preparative Centrifugation 425\u003c\/p\u003e \u003cp\u003e18.8 Density Centrifugation 427\u003c\/p\u003e \u003cp\u003e18.9 Viscosity 428\u003c\/p\u003e \u003cp\u003e18.10 Electrophoresis 429\u003c\/p\u003e \u003cp\u003e18.11 Peptide-Induced Conformational Change of a Major Histocompatibility Complex Protein 432\u003c\/p\u003e \u003cp\u003e18.12 Ultracentrifuge Analysis of Protein–DNA Interactions 434\u003c\/p\u003e \u003cp\u003eReferences 435\u003c\/p\u003e \u003cp\u003eProblems 435\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19. Mass Spectrometry 441\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e19.1 Introduction 441\u003c\/p\u003e \u003cp\u003e19.2 Mass Analysis 441\u003c\/p\u003e \u003cp\u003e19.3 Tandem Mass Spectrometry (MS\/MS) 445\u003c\/p\u003e \u003cp\u003e19.4 Ion Detectors 445\u003c\/p\u003e \u003cp\u003e19.5 Ionization of the Sample 446\u003c\/p\u003e \u003cp\u003e19.6 Sample Preparation\/Analysis 449\u003c\/p\u003e \u003cp\u003e19.7 Proteins and Peptides 450\u003c\/p\u003e \u003cp\u003e19.8 Protein Folding 452\u003c\/p\u003e \u003cp\u003e19.9 Other Biomolecules 455\u003c\/p\u003e \u003cp\u003eReferences 455\u003c\/p\u003e \u003cp\u003eProblems 456\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAPPENDICES 457\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix 1. Useful Constants and Conversion Factors 459\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix 2. Structures of the Common Amino Acids at Neutral pH 461\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix 3. Common Nucleic Acid Components 463\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix 4. Standard Gibbs Energies and Enthalpies of Formation at 298 K, 1 atm, pH 7, and 0.25 M Ionic Strength 465\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix 5. Standard Gibbs Energy and Enthalpy Changes for Biochemical Reactions at 298 K, 1 atm, pH 7.0, pMg 3.0, and 0.25M Ionic Strength 467\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix 6. Introduction to Electrochemistry 469\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eA6-1 Introduction 469\u003c\/p\u003e \u003cp\u003eA6-2 Galvanic Cells 469\u003c\/p\u003e \u003cp\u003eA6-3 Standard Electrochmical Potentials 471\u003c\/p\u003e \u003cp\u003eA6-4 Concentration Dependence of the Electrochemical Potential 472\u003c\/p\u003e \u003cp\u003eA6-5 Biochemical Redox Reactions 473\u003c\/p\u003e \u003cp\u003eReferences 473\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex 475\u003c\/b\u003e\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":51039263686999,"sku":"9781118859001","price":132.26,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118859001.jpg?v=1750943094","url":"https:\/\/bookcurl.com\/products\/physical-chemistry-for-the-biological-sciences-9781118859001","provider":"Book Curl","version":"1.0","type":"link"}