{"product_id":"phenotyping-of-human-ipscderived-neurons-9780128222775","title":"Phenotyping of Human iPSCderived Neurons","description":"\u003cbr\u003e\u003cbr\u003eTable of Contents\u003cbr\u003eSection I: Best practices and considerations when designing a new project 1. iPSC culture: best practices from sample procurement to reprogramming and differentiation 2. Phenotypic assay development with iPSC-derived neurons: technical 3. Derivation of cortical interneurons from human pluripotent stem cells to model neurodevelopmental disorders 4. Development of transcription factor-based strategies for neuronal differentiation from pluripotent stem cells 5. Differentiation of Purkinje cells from pluripotent stem cells for disease phenotyping in vitro 6. Brain organoids: models of cell type diversity, connectivity, and disease phenotypes   Section II: The use of iPSC-derived neurons to study neurological disorders 7. Human models as new tools for drug development and precision medicine 8. Use of cerebral organoids to model environmental and gene x environment interactions in the developing fetus and neurodegenerative disorders 9. iPSC-derived models of autism: Tools for patient phenotyping and assay-based drug discovery 10. Probing the electrophysiological properties of patient-derived neurons across neurodevelopmental disorders 11. Advantages and limitations of hiPSC-derived neurons for the study of neurodegeneration   Section III: New technology, industry perspective, and transitioning to the clinic 12. Developing clinically translatable screens using iPSC-derived neural cells 13. Gene editing hPSCs for modeling neurological disorders 14. Cell therapy and biomanufacturing using hiPSC-derived neurons 15. Ethical considerations for the use of stem cell-derived therapies","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":51618731458903,"sku":"9780128222775","price":86.25,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780128222775.jpg?v=1756903044","url":"https:\/\/bookcurl.com\/products\/phenotyping-of-human-ipscderived-neurons-9780128222775","provider":"Book Curl","version":"1.0","type":"link"}