{"product_id":"parkinson-disease-contemporary-neurology-series-9780190843014","title":"Parkinson Disease CONTEMPORARY NEUROLOGY SERIES","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eParkinson Disease is a comprehensive introduction to the biology and clinical features of Parkinson disease (PD). Topics covered include nosology of PD, PD epidemiology, pathology and pathophysiology of PD, and theories of PD pathogenesis. This book intends to be a useful overview, bridging the gap between general textbooks and specific topical reviews.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eChapter 1: Definition, History, Nosology, and Classification Introduction and Definition      Brief History of PD Nosology and Classification Scheme  Classification Level 1 Classification Level 2 Ambiguities and Future Directions Conclusion  Chapter 2: Epidemiology Introduction Prevalence Incidence Mortality Risk Factors Implications for Understanding Etiopathogenesis and the Future Burden of PD  Chapter 3: Pathology Introduction The Aging Brain Gross Pathology, Lewy Pathology, and a-Synucleinopathy  Substantia Nigra Pars Compacta Pathology Idiopathic Lewy Body Disease (iLBD)  The Braak et al. Staging System Synucleinopathy Outside the Brain Non-Synuclein Pathologies  Chapter 4: Pathophysiology I - Basal Ganglia Architecture and the Standard Model Introduction Basic Basal Ganglia Architecture The \"Standard\" Model of Basal Ganglia Pathophysiology  Complexities of Basal Ganglia Architecture Conclusion  Chapter 5: Pathophysiology II - Neurotransmitter System Dysfunctions Introduction Nigrostriatal Dopamine Signaling Functions  Habit Formation and Chunking Cholinergic Projection System Dysfunctions  Serotoninergic System Dysfunctions  Conclusions and Future Challenges  Chapter 6: Genetics of Parkinson Disease Introduction Dominant Forms of PD  Recessive Forms of PD GBA PD Genetic Risk Factors  Implications of PD Genetic Research  Chapter 7: Pathogenesis Neuronal Vulnerability Alpha-Synuclein The Prion-Like Hypothesis Mitochondrial Dysfunction Oxidative Stress Endolysosomal Dysfunction  Neuroinflammation Neuroprotection Trials Conclusions  Chapter 8: Prodromal Parkinson Disease Introduction REM Sleep Behavior Disorder  Observational Studies REM Sleep Behavior Disorder Cohort Studies  Genetic Cohort Studies Autonomic Failure Future Directions  Chapter 9: Clinical Features I - Initial Evaluation Presentation Features Nature of Diagnosis and Diagnostic Criteria  History and Examination  Differential Diagnosis Treatment Responsiveness  Diagnostic Accuracy  Chapter 10: Clinical Features II - Non-Motor Features Introduction Cognitive Impairments Neuropsychiatric Disorders  Sleep Disorders Pain Fatigue Autonomic Disorders  Visual Disorders Oral Health Conclusion  Chapter 11: Clinical Features III - Natural History  Introduction Assessing PD Progression PD Progression - Clinically Salient Features Subgroups Natural History Summary  Continuing Care End of Life Care  Chapter 12: Pharmacology I - L-Dopa Pharmacokinetics and Pharmacodynamics Introduction Dopaminergic Neurotransmission   L-Dopa Pharmacokinetics L-Dopa Pharmacodynamics Peak Dose Dyskinesias Interactions of L-Dopa Pharmacokinetics, Pharmacodynamics, and Disease Progression Summary and Future Directions  Chapter 13: Pharmacology II - Treating Parkinson Disease Introduction Using L-Dopa When the Honeymoon Is Over L-Dopa Adjuncts Dopamine Agonists  Cholinergic Agents Other Symptomatic Therapies Future Directions  Chapter 14: Surgery Introduction Deep Brain Stimulation: Rationale and Possible Mechanisms  Deep Brain Stimulation: Procedures Deep Brain Stimulation: STN DBS Benefits Deep Brain Stimulation: GPi DBS Benefits and STN vs GPi DBS Deep Brain Stimulation: Adverse Events Lesional Procedures Cell-Based and Gene Therapies Future Directions  Coda: Looking Ahead","brand":"Oxford University Press Inc","offers":[{"title":"Default Title","offer_id":48732543517015,"sku":"9780190843014","price":132.5,"currency_code":"GBP","in_stock":false}],"url":"https:\/\/bookcurl.com\/products\/parkinson-disease-contemporary-neurology-series-9780190843014","provider":"Book Curl","version":"1.0","type":"link"}