{"product_id":"pain-genetics-9781118398845","title":"Pain Genetics","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003ci\u003ePain Genetics: Basic to Translational Science\u003c\/i\u003eis a timely synthesis of the key areas of research informing our understanding of the genetic basis of pain. The book opens with foundational information on basic genetic mechanisms underlying pain perception and progresses recently discovered complex concepts facing the field. The coverage is wide-ranging and will serves as an excellent entry point into understating the genetics of pain as well as providing a single resource for established researchers looking for a better understanding of the diverse strands of research going on in the area.\u003cbr\u003e \u003cbr\u003e With contributors painstakingly selected to provide a broad range of perspectives and research,\u003ci\u003ePain Genetics\u003c\/i\u003ewill be a valuable resource for geneticists, neuroscientists, and biomedical professionals alike.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eEditors’ Biographies xi\u003c\/p\u003e \u003cp\u003eContributors xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 How Do Pain Genes Affect Pain Experience? 1\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMarshall Devor\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 2\u003c\/p\u003e \u003cp\u003eHeritability of Pain: Historical Roots 2\u003c\/p\u003e \u003cp\u003eWhy is Pain Genetics Interesting and Potentially Useful? 4\u003c\/p\u003e \u003cp\u003eWhat Are Pain Genes? 8\u003c\/p\u003e \u003cp\u003eHow Do Pain Genes Affect Pain Experience? 9\u003c\/p\u003e \u003cp\u003eDisease Susceptibility Genes Versus Pain Susceptibility Genes 12\u003c\/p\u003e \u003cp\u003ePerspective 13\u003c\/p\u003e \u003cp\u003eAcknowledgments 13\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Conservation of Pain Genes Across Evolution 15\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eThang Manh Khuong and G. Greg Neely\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 15\u003c\/p\u003e \u003cp\u003eAnatomical Organization of Nociception Apparatus in Mammals and Drosophila 16\u003c\/p\u003e \u003cp\u003eAcute Heat Pain in Mammals 16\u003c\/p\u003e \u003cp\u003eAcute Heat Nociception in Drosophila 18\u003c\/p\u003e \u003cp\u003eMechanical Pain in Mammals 19\u003c\/p\u003e \u003cp\u003eMechanical Nociception in Drosophila 19\u003c\/p\u003e \u003cp\u003eChemical Nociception in Mammals 21\u003c\/p\u003e \u003cp\u003eChemical Nociception in Drosophila 21\u003c\/p\u003e \u003cp\u003eInflammatory Pain in Mammals 22\u003c\/p\u003e \u003cp\u003ePersistent Pain in Drosophila 22\u003c\/p\u003e \u003cp\u003eNeuropathic Pain in Mammals 25\u003c\/p\u003e \u003cp\u003eStructural Reorganizations of Nerve Fibers in Neuropathic Pain 25\u003c\/p\u003e \u003cp\u003eMammalian Neuropathic Pain Genes That Are Conserved in Drosophila 25\u003c\/p\u003e \u003cp\u003eLong-Term Potentiation and Long-Term Depression in Neuropathic Pain in Mammals 28\u003c\/p\u003e \u003cp\u003eNeuropathic Pain in Drosophila 30\u003c\/p\u003e \u003cp\u003eConclusions 30\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Defining Human Pain Phenotypes for Genetic Association Studies 37\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eChristopher Sivert Nielsen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 37\u003c\/p\u003e \u003cp\u003eWhat is a Pain Phenotype? 38\u003c\/p\u003e \u003cp\u003ePain Scaling 39\u003c\/p\u003e \u003cp\u003eHeritability 40\u003c\/p\u003e \u003cp\u003eGenotype–Phenotype Matching 41\u003c\/p\u003e \u003cp\u003eReliability and Temporal Stability 41\u003c\/p\u003e \u003cp\u003eClinical Phenotypes 43\u003c\/p\u003e \u003cp\u003eDesigning Clinical Pain Genetic Studies 43\u003c\/p\u003e \u003cp\u003eThe Heritability of Specific Clinical Pain Conditions 45\u003c\/p\u003e \u003cp\u003eExperimental Phenotypes 45\u003c\/p\u003e \u003cp\u003eThe Heritability of Experimental Phenotypes 46\u003c\/p\u003e \u003cp\u003eExtended Phenotypes 47\u003c\/p\u003e \u003cp\u003ePractical Concerns 47\u003c\/p\u003e \u003cp\u003eConclusions 48\u003c\/p\u003e \u003cp\u003eConflict of Interest Statement 48\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Genetic Contributions to Pain and Analgesia: Interactions with Sex and Stress 51\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eRoger B. Fillingim and Jeffrey S. Mogil\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 51\u003c\/p\u003e \u003cp\u003eBrief Overview of Sex and Gender Differences in Pain and Analgesia 52\u003c\/p\u003e \u003cp\u003eBrief Overview of Stress and Pain\/Analgesia 52\u003c\/p\u003e \u003cp\u003eSex X Gene Interactions in Pain and Analgesia 53\u003c\/p\u003e \u003cp\u003eSummary 57\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Abnormal Pain Conditions in Humans Related to Genetic Mutations 61\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eChristopher Geoffrey Woods\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction to SCN9A, NTRK1, and NGF and the Roles They Play in Pain 61\u003c\/p\u003e \u003cp\u003eIntroduction to SCN9A and Its Omnipotent Role in Pain Sensing 62\u003c\/p\u003e \u003cp\u003eIntroduction to NTRK1 and Its Role in Development and Function in the Pain and Sympathetic Nervous Systems 69\u003c\/p\u003e \u003cp\u003eIntroduction to NGF, the First Nerve Growth Factor to Be Found and Studied 72\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Alternative Pre-mRNA Splicing of Mu Opioid Receptor Gene: Molecular Mechanisms Underlying the Complex Actions of Mu Opioids 79\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eYing-Xian Pan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 79\u003c\/p\u003e \u003cp\u003eEvolution of OPRM1 Gene 80\u003c\/p\u003e \u003cp\u003eOPRM1 Gene: Chromosomal Location and Gene Structure 82\u003c\/p\u003e \u003cp\u003eAlternative Promoters 82\u003c\/p\u003e \u003cp\u003eAlternative Pre-mRNA Splicing of the OPRM1 Gene 83\u003c\/p\u003e \u003cp\u003eExpression and Function of the OPRM1 Splice Variants 90\u003c\/p\u003e \u003cp\u003eConclusion 94\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Discovering Multilocus Associations with Complex Pain Phenotypes 99\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eChia-Ling Kuo, Luda Diatchenko, and Dmitri Zaykin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 99\u003c\/p\u003e \u003cp\u003eApproaches Based on Testing Individual Genetic Variants Within a Region 100\u003c\/p\u003e \u003cp\u003eApproaches That Combine Association Signals Across Genetic Variants 101\u003c\/p\u003e \u003cp\u003eMethods for Testing Joint Effects of Multiple Genetic Variants 102\u003c\/p\u003e \u003cp\u003eMultilocus Analysis of Mu Opioid Receptor Haplotypes 103\u003c\/p\u003e \u003cp\u003eTwo-Stage Multilocus Association Analysis: Collapsing SNPs with Adjustment for Effect Directions 104\u003c\/p\u003e \u003cp\u003eTwo-Stage Approach: Simulations 107\u003c\/p\u003e \u003cp\u003eTwo-Stage Approach: Results 108\u003c\/p\u003e \u003cp\u003eDiscussion 111\u003c\/p\u003e \u003cp\u003eAcknowledgments 113\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Overlapping Phenotypes: Genetic Contribution to Nausea and Pain 115\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eCharles C. Horn\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 115\u003c\/p\u003e \u003cp\u003eWhat is the Functional Role of Nausea and Vomiting? 117\u003c\/p\u003e \u003cp\u003ePain Syndromes with Significant Nausea 118\u003c\/p\u003e \u003cp\u003eThe Neuropharmacology of Nausea and Emesis 119\u003c\/p\u003e \u003cp\u003eEmetic and Antiemetic Action of Opioids 121\u003c\/p\u003e \u003cp\u003ePreclinical Studies of Nausea and Vomiting 122\u003c\/p\u003e \u003cp\u003eHeritability of Nausea and Vomiting Phenotypes 123\u003c\/p\u003e \u003cp\u003eHuman Genetic Sequence Variants Associated with Nausea and Vomiting 124\u003c\/p\u003e \u003cp\u003eSummary and Future Directions 125\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 A Counterpart to Pain: Itch 131\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eAdam P. Kardon and Sarah E. Ross\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 131\u003c\/p\u003e \u003cp\u003eWhy Do We Scratch? 132\u003c\/p\u003e \u003cp\u003eThe Basics of Itch 132\u003c\/p\u003e \u003cp\u003eSo How is Itch Coded? 133\u003c\/p\u003e \u003cp\u003eMeasuring Itch in Mice 134\u003c\/p\u003e \u003cp\u003eGenetic Models of Itch 135\u003c\/p\u003e \u003cp\u003eA Key Role for the Skin in Itch 141\u003c\/p\u003e \u003cp\u003eA Shift in the Balance of Pain and Itch 141\u003c\/p\u003e \u003cp\u003eGenetic Variation and Itch in Humans – Challenges for the Future 143\u003c\/p\u003e \u003cp\u003eAcknowledgments 143\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Translating Genetic Knowledge into Clinical Practice for Musculoskeletal Pain Conditions 147\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eLuda Diatchenko, Shad B. Smith, and William Maixner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 147\u003c\/p\u003e \u003cp\u003eResults of Human Association Studies 148\u003c\/p\u003e \u003cp\u003eGene Sequencing 150\u003c\/p\u003e \u003cp\u003eDevelopment of New Therapeutics 150\u003c\/p\u003e \u003cp\u003eUnderstanding of Interactions 155\u003c\/p\u003e \u003cp\u003eIn Summary 156\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 The Human Chronic Pain Phenome: Mapping Nongenetic Modifiers of the Heritable Risk 161\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eZe’ev Seltzer, Scott R. Diehl, Hance Clarke, and Joel Katz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eThe Current Crisis in Pain Medicine 162\u003c\/p\u003e \u003cp\u003eThe Importance of Estimating Risk of Chronic Neuropathic Pain (CNP) 162\u003c\/p\u003e \u003cp\u003eModification of the Heritable Risk for CNP 163\u003c\/p\u003e \u003cp\u003eThe Natural History of CNP 165\u003c\/p\u003e \u003cp\u003eModification of Heritable Risk for CNP In Utero 166\u003c\/p\u003e \u003cp\u003eModifications of the Heritable Risk for CNP Across Generations 167\u003c\/p\u003e \u003cp\u003ePostnatal Modifications of the Heritable Risk for CNP 168\u003c\/p\u003e \u003cp\u003eModifications of the Heritable Risk for CNP by Childhood Adverse Experiences 168\u003c\/p\u003e \u003cp\u003eModifications of the Heritable Risk for CNP by Prior Chronic Pain Epochs 169\u003c\/p\u003e \u003cp\u003eModification of the Heritable Risk for CNP by Certain Personality Traits 172\u003c\/p\u003e \u003cp\u003eModification of the Heritable Risk for CNP by Social Factors 172\u003c\/p\u003e \u003cp\u003eModification of the Heritable Risk for CNP by Diet, Medications, Smoking, and Alcohol Intake Consumed Preoperatively 174\u003c\/p\u003e \u003cp\u003eModification of the Heritable Risk for CNP by Climate 175\u003c\/p\u003e \u003cp\u003eModification of the Heritable Risk for CNP by Lifestyle 175\u003c\/p\u003e \u003cp\u003eModifications of the Heritable Risk for Chronic Pain by Other Diseases 176\u003c\/p\u003e \u003cp\u003eModifications of the Heritable Risk for CNP by Nongenetic Factors Occurring Just Prior and During the Inciting Event 176\u003c\/p\u003e \u003cp\u003eSummary 177\u003c\/p\u003e \u003cp\u003eAppendix: List of Abbreviations 183\u003c\/p\u003e \u003cp\u003eIndex 185\u003c\/p\u003e \u003cp\u003eColor insert found between pages 114 and 115\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49406864490839,"sku":"9781118398845","price":132.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118398845.jpg?v=1730497377","url":"https:\/\/bookcurl.com\/products\/pain-genetics-9781118398845","provider":"Book Curl","version":"1.0","type":"link"}