{"product_id":"origins-and-directions-of-inflammatory-bowel-disease-early-studies-of-the-nonspecific-inflammatory-bowel-diseases-9789401038744","title":"Origins and Directions of Inflammatory Bowel Disease: Early Studies of the “Nonspecific” Inflammatory Bowel Diseases","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003eFew human illnesses today are so challenging, medically,  scientifically, and socio-economically, as the \"nonspecific\"  inflammatory bowel diseases (IBD): ulcerative colitis and Crohn's  disease. Originating several centuries ago but essentially diseases of  the 20th century, often attacking children and young adults, involving  all bodily systems as well as the gastrointestinal tract, ulcerative  colitis and Crohn's disease have emerged in recent decades as among  the more \"glamorous\" unsolved diseases, presenting unusual  opportunities for insightful clinical and investigative study. Many of  the prevailing concepts originated during the early and mid 20th  century. The purpose of \u003cem\u003eOrigins and Directions of Inflammatory  Bowel\u003c\/em\u003e \u003cem\u003eDisease\u003c\/em\u003e is to review these earlier studies and their  evolution \"from the mystical to the molecular,\" and guide  investigators and physicians through the challenging clinical and  scientific maze of IBD.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eUlcerative colitis.- Early IBD-related events.- Beginnings.- Increasing clinical recognition.- Initial pathology of ulcerative colitis and its pathogenic implications.- Pathology — electron microscopy — ulcerative colitis.- “Natural” and experimental ulcerative colitis.- References.- Crohn’s disease.- Origins.- Early clinical recognition.- Animal and experimental Crohn’s disease.- Abdominal trauma.- The early Mt. Sinai (New York) experience.- More early 20th century reports (CD).- Crohn’s disease of the colon — delayed recognition.- Early pathology of Crohn’s disease.- Electron microscopy — Crohn’s disease.- Origin of eponym of Crohn’s disease.- References.- Etiology of pathogenesis of IBD — origins and directions.- Epidemiology.- Psychogenic aspects (UC, CD).- Microbial aspects — ulcerative colitis.- Microbial aspects — Crohn’s disease.- Immune mechanisms.- M cell.- Epithelial permeability.- Inflammation (cytokines, lymphokines).- Genetic aspects of inflammatory bowel disease — early observations.- Concluding commentary.- References.- The early treatment of inflammatory bowel disease.- References.- References.- Additional early publications on inflammatory bowel disease.","brand":"Springer","offers":[{"title":"Default Title","offer_id":51743199953239,"sku":"9789401038744","price":42.74,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9789401038744.jpg?v=1758389438","url":"https:\/\/bookcurl.com\/products\/origins-and-directions-of-inflammatory-bowel-disease-early-studies-of-the-nonspecific-inflammatory-bowel-diseases-9789401038744","provider":"Book Curl","version":"1.0","type":"link"}