{"product_id":"oral-wound-healing-9780813804811","title":"Oral Wound Healing","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eOral Wound Healing: Cell Biology and Clinical Management\u003c\/i\u003e brings experts from around the world together to provide an authoritative reference on the processes, principles and clinical management of wound healing in the oral mucosa. Promoting a thorough understanding of current research on the topic, this new resource draws together thinking on the basic biological processes of wound healing in the oral environment, as well as providing more detailed information and discussion on processes such as inflammation, reepithelialization and angiogenesis. Beyond this, the book goes on to examine topics pertinent to the effective clinical management of oral wound healing, bringing together chapters on large dento-facial defects, dental implants, periodontal regeneration, and pulp healing.An essential synthesis of current research and clinical applications, \u003ci\u003eOral Wound Healing\u003c\/i\u003e will be an indispensable resource for dental specialists, oral and maxillofacial surgeons as well as researc\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003eContributors xiii  \u003cp\u003ePreface xvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Oral Wound Healing: An Overview 1\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eHannu Larjava\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eClotting and inflammation (chapters 2, 3 and 4) 1\u003c\/p\u003e \u003cp\u003eRe-epithelialization and granulation tissue formation (chapters 5 and 6) 2\u003c\/p\u003e \u003cp\u003eAngiogenesis (chapter 7) 3\u003c\/p\u003e \u003cp\u003eHealing of extraction sockets (chapter 8) 4\u003c\/p\u003e \u003cp\u003eFlap design for periodontal wound healing (chapter 9) 4\u003c\/p\u003e \u003cp\u003eRegeneration of periodontal tissues (chapters 10 and 11) 5\u003c\/p\u003e \u003cp\u003eOsteointegration and soft tissue healing around dental implants (chapter 12) 6\u003c\/p\u003e \u003cp\u003eThe pulp healing process (chapter 13) 7\u003c\/p\u003e \u003cp\u003eDermal wound healing and burn wounds (chapter 14) 7\u003c\/p\u003e \u003cp\u003eHealing of large dentofacial defects (chapter 15) 8\u003c\/p\u003e \u003cp\u003eReferences 9\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Hemostasis, Coagulation and Complications 11\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eCarol Oakley and Hannu Larjava\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 11\u003c\/p\u003e \u003cp\u003ePrimary hemostasis 12\u003c\/p\u003e \u003cp\u003eSecondary hemostasis and the coagulation system 13\u003c\/p\u003e \u003cp\u003eTertiary hemostasis 16\u003c\/p\u003e \u003cp\u003eTissue factor 16\u003c\/p\u003e \u003cp\u003eVon willebrand factor 17\u003c\/p\u003e \u003cp\u003eOther coagulation factors 17\u003c\/p\u003e \u003cp\u003eCell-centric model of hemostasis: from initiation to propagation 18\u003c\/p\u003e \u003cp\u003eThe procoagulant membrane 20\u003c\/p\u003e \u003cp\u003eMembrane particles 22\u003c\/p\u003e \u003cp\u003eEndothelium and hemostasis 22\u003c\/p\u003e \u003cp\u003ePro- and anticoagulant functions 22\u003c\/p\u003e \u003cp\u003ePlatelets 24\u003c\/p\u003e \u003cp\u003eCoagulation and wound healing 26\u003c\/p\u003e \u003cp\u003eLimitations of the waterfall cascade model and screening laboratory tests 26\u003c\/p\u003e \u003cp\u003eImplications for laboratory tests 27\u003c\/p\u003e \u003cp\u003ePre-surgical evaluation to prevent bleeding problems 27\u003c\/p\u003e \u003cp\u003eConclusions 32\u003c\/p\u003e \u003cp\u003eReferences 32\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Inflammation and Wound Healing 39\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAnna Turabelidze and Luisa Ann DiPietro\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 39\u003c\/p\u003e \u003cp\u003eThe innate immune response in wounds 39\u003c\/p\u003e \u003cp\u003eInflammatory cell infiltration into wounds 40\u003c\/p\u003e \u003cp\u003eInflammatory cell function in wounds 41\u003c\/p\u003e \u003cp\u003eCytokines and chemokines in wounds 44\u003c\/p\u003e \u003cp\u003eInflammation in oral mucosal wounds 47\u003c\/p\u003e \u003cp\u003eInflammation in fetal wounds 48\u003c\/p\u003e \u003cp\u003eRole of inflammation in keloids 49\u003c\/p\u003e \u003cp\u003eInflammation and diabetic wounds 49\u003c\/p\u003e \u003cp\u003eConclusions 50\u003c\/p\u003e \u003cp\u003eReferences 50\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Specialized Pro-resolving Lipid Derived Fatty Acid Mediators: Wiring the Circuitry of Effector Immune Homeostasis 57\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eGabrielle Fredman and Charles N. Serhan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eInflammation: the cardinal signs 57\u003c\/p\u003e \u003cp\u003eComplete resolution and tissue homeostasis is the ideal outcome of acute inflammation 58\u003c\/p\u003e \u003cp\u003eLipoxins, resolvins, protectins and maresins: semper vigilantes of anti-inflammation and pro-resolution 60\u003c\/p\u003e \u003cp\u003eResolution of inflammation is an actively regulated process \u003ci\u003ein vivo\u003c\/i\u003e 66\u003c\/p\u003e \u003cp\u003eResolvins and protectins are protective in experimental models of inflammatory diseases 67\u003c\/p\u003e \u003cp\u003eSpecialized pro-resolving lipid mediators in oral medicine: restoration of tissue homeostasis in experimental periodontitis 70\u003c\/p\u003e \u003cp\u003eResolution and wound healing 72\u003c\/p\u003e \u003cp\u003eAnti-inflammation vs. Pro-resolution 72\u003c\/p\u003e \u003cp\u003eClinical implications and the development of stable analogs 74\u003c\/p\u003e \u003cp\u003eConclusions 74\u003c\/p\u003e \u003cp\u003eAcknowledgments 75\u003c\/p\u003e \u003cp\u003eReferences 75\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Re-epithelialization of Wounds 81\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eLeeni Koivisto, Lari Häkkinen and Hannu Larjava\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 81\u003c\/p\u003e \u003cp\u003eKeratinocytes form a protective barrier between an organism and its environment 81\u003c\/p\u003e \u003cp\u003eKeratinocytes are activated rapidly to restore the epithelial barrier after wounding 82\u003c\/p\u003e \u003cp\u003eMany different factors contribute to re-epithelialization 84\u003c\/p\u003e \u003cp\u003eFinal stages of re-epithelialization 106\u003c\/p\u003e \u003cp\u003eFailure to re-epithelialize: chronic wounds 107\u003c\/p\u003e \u003cp\u003eConclusions 107\u003c\/p\u003e \u003cp\u003eReferences 108\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Granulation Tissue Formation and Remodeling 125\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eLari Häkkinen, Hannu Larjava and Leeni Koivisto\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 125\u003c\/p\u003e \u003cp\u003eOverview of connective tissue response to wounding 126\u003c\/p\u003e \u003cp\u003eWound healing stages 129\u003c\/p\u003e \u003cp\u003eOrigin and identity of wound fibroblasts 129\u003c\/p\u003e \u003cp\u003eGranulation tissue formation 134\u003c\/p\u003e \u003cp\u003eConnective tissue remodeling 151\u003c\/p\u003e \u003cp\u003eRe-emergence of quiescent fibroblast phenotype 156\u003c\/p\u003e \u003cp\u003eSpecific features of oral mucosal wound healing 157\u003c\/p\u003e \u003cp\u003eConclusions 159\u003c\/p\u003e \u003cp\u003eAcknowledgments 159\u003c\/p\u003e \u003cp\u003eReferences 159\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Angiogenesis and Wound Healing: Basic Discoveries, Clinical Implications and Therapeutic Opportunities 175\u003cbr\u003e \u003c\/b\u003e\u003ci\u003ePeter J. Polverini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 175\u003c\/p\u003e \u003cp\u003eHow blood vessels develop 175\u003c\/p\u003e \u003cp\u003eEarly mechanistic insights into the angiogenic response: from solid tumors to chronic inflammation and wound healing 177\u003c\/p\u003e \u003cp\u003eThe role of other inflammatory cells in angiogenesis 179\u003c\/p\u003e \u003cp\u003eMatrix molecules 180\u003c\/p\u003e \u003cp\u003eVascular endothelial growth factor and the modern era of angiogenesis research 181\u003c\/p\u003e \u003cp\u003eSignaling networks of potential importance in wound neovascularization 182\u003c\/p\u003e \u003cp\u003eInhibitors of angiogenesis: important counterweights in wound neovascularization 184\u003c\/p\u003e \u003cp\u003eThe role of aberrant wound angiogenesis in the pathogenesis of diabetes mellitus 186\u003c\/p\u003e \u003cp\u003eConclusions 187\u003c\/p\u003e \u003cp\u003eReferences 188\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Wound Healing of Extraction Sockets 195\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eRoberto Farina and Leonardo Trombelli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eHealing of extraction sockets 195\u003c\/p\u003e \u003cp\u003eFactors influencing the healing of extraction sockets 202\u003c\/p\u003e \u003cp\u003eHealing of extraction sockets following immediate implant placement 203\u003c\/p\u003e \u003cp\u003eDoes the use of reconstructive technologies alter the healing of extraction sockets? 211\u003c\/p\u003e \u003cp\u003eConclusions 223\u003c\/p\u003e \u003cp\u003eReferences 223\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Flap Designs for Periodontal Healing 229\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eLeonardo Trombelli and Roberto Farina\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eFlap management, wound stability and periodontal regeneration 229\u003c\/p\u003e \u003cp\u003eFlap designs to achieve primary closure 230\u003c\/p\u003e \u003cp\u003eSurgical treatment of periodontal intraosseous defects: technical hints 237\u003c\/p\u003e \u003cp\u003eConclusions 240\u003c\/p\u003e \u003cp\u003eReferences 241\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Periodontal Regeneration: Experimental Observations – Clinical Consequences 243\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eUlf M.E. Wikesjö, Cristiano Susin, Jaebum Lee, Douglas P. Dickinson and Giuseppe Polimeni\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 243\u003c\/p\u003e \u003cp\u003eWound healing 244\u003c\/p\u003e \u003cp\u003ePeriodontal wound healing 245\u003c\/p\u003e \u003cp\u003ePeriodontal regeneration – new attachment 247\u003c\/p\u003e \u003cp\u003eWound stability 248\u003c\/p\u003e \u003cp\u003eSpace provision 251\u003c\/p\u003e \u003cp\u003eWound closure for primary intention healing 256\u003c\/p\u003e \u003cp\u003eConclusions 256\u003c\/p\u003e \u003cp\u003eAcknowledgment 257\u003c\/p\u003e \u003cp\u003eReferences 257\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Biological Agents and Cell Therapies in Periodontal Regeneration 261\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eHannu Larjava, Yi Yang, Edward Putnins, Jyrki Heino and Lari Häkkinen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 261\u003c\/p\u003e \u003cp\u003eAdjunct growth factors in periodontal wound repair 261\u003c\/p\u003e \u003cp\u003ePDGF and IGF-1 in periodontal regeneration 262\u003c\/p\u003e \u003cp\u003ePlatelet-rich plasma in periodontal therapy 265\u003c\/p\u003e \u003cp\u003eFGF-2 in periodontal regeneration 265\u003c\/p\u003e \u003cp\u003eGrowth and differentiation factor-5 in periodontal regeneration 266\u003c\/p\u003e \u003cp\u003eOther growth factors in periodontal regeneration 267\u003c\/p\u003e \u003cp\u003eBioactive collagen-derived peptide in periodontal regeneration (PepGen P-15®) 267\u003c\/p\u003e \u003cp\u003eEnamel matrix proteins in periodontal regeneration and wound healing 269\u003c\/p\u003e \u003cp\u003eStem cells in periodontal wound healing 273\u003c\/p\u003e \u003cp\u003eConclusions 275\u003c\/p\u003e \u003cp\u003eReferences 275\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Wound Healing Around Dental Implants 287\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eCristina Cunha Villar, Guy Huynh-Ba, Michael P. Mills and David L. Cochran\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eIntroduction 287\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eHistorical development 287\u003c\/p\u003e \u003cp\u003eTitanium – the metal of choice 290\u003c\/p\u003e \u003cp\u003eHealing following implant placement 291\u003c\/p\u003e \u003cp\u003ePeri-implant soft tissue healing 291\u003c\/p\u003e \u003cp\u003eImplant\/peri-implant mucosa interface 292\u003c\/p\u003e \u003cp\u003ePeri-implant hard tissue healing 294\u003c\/p\u003e \u003cp\u003eFrom healing to clinical application 296\u003c\/p\u003e \u003cp\u003eImplant stability testing 297\u003c\/p\u003e \u003cp\u003eWound healing and loading protocols 302\u003c\/p\u003e \u003cp\u003eConclusions 303\u003c\/p\u003e \u003cp\u003eReferences 304\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 The Pulp Healing Process: From Generation to Regeneration 313\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eStéphane Simon, Anthony J. Smith, Philip J. Lumley, Paul R. Cooper, and Ariane Berdal\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eFrom generation to regeneration 313\u003c\/p\u003e \u003cp\u003eAt the molecular level 323\u003c\/p\u003e \u003cp\u003eConclusion 328\u003c\/p\u003e \u003cp\u003eReferences 328\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Dermal Wound Healing and Burn Wounds 333\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAnthony Papp\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 333\u003c\/p\u003e \u003cp\u003eBurn injury 333\u003c\/p\u003e \u003cp\u003eSkin anatomy 334\u003c\/p\u003e \u003cp\u003eBurn depth 336\u003c\/p\u003e \u003cp\u003eWound healing 338\u003c\/p\u003e \u003cp\u003eTreatment 340\u003c\/p\u003e \u003cp\u003eSpecial features in perioral burns 342\u003c\/p\u003e \u003cp\u003eConclusions 343\u003c\/p\u003e \u003cp\u003eReferences 344\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Healing of Large Dentofacial Defects 347\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eGeorge K.B. Sándor, Robert P. Carmichael, Leena P. Ylikontiola, Ahmed Jan, Marc G. DuVal and Cameron M.L. Clokie\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 347\u003c\/p\u003e \u003cp\u003eThe need for bone 349\u003c\/p\u003e \u003cp\u003eBone healing 349\u003c\/p\u003e \u003cp\u003eSurgical maneuvers to induce and promote healing of large defects 355\u003c\/p\u003e \u003cp\u003eSpecifically difficult wounds 383\u003c\/p\u003e \u003cp\u003eConclusions 391\u003c\/p\u003e \u003cp\u003eReferences 392\u003c\/p\u003e \u003cp\u003eIndex 397\u003c\/p\u003e","brand":"John Wiley and Sons Ltd","offers":[{"title":"Default Title","offer_id":49527931044183,"sku":"9780813804811","price":134.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780813804811.jpg?v=1731869773","url":"https:\/\/bookcurl.com\/products\/oral-wound-healing-9780813804811","provider":"Book Curl","version":"1.0","type":"link"}