{"product_id":"nonclinical-vascular-infusion-technology-volume-i-9781439874493","title":"NonClinical Vascular Infusion Technology Volume I","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eIntravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. For the first time, the collective sciences involved in the understanding of this mode of drug delivery are brought together in one publication.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eNon-Clinical Vascular Infusion Technology, Volume I: The Science\u003c\/b\u003e covers the scientific principles behind the delivery systems, from both physical and physiological standpoints. The book addresses body fluid dynamics, describes the scientific processes necessary to understand the various aspects of the physico-chemical issues relating to vascular infusion delivery, and discusses vascular infusion dynamics. It also considers all the essential elements of the preparation of a formulation intended for vascula\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\"Good science and good welfare go hand in hand. Innovative science and technology can be used to improve animal welfare. Equally, the 3Rs (replacement, refinement and reduction of animals in research) can provide fresh insight and novel approaches to advance science. By sharing data, knowledge and experience on the science behind infusion models and the refinement of the techniques used, there is the potential to have a significant impact on the 3Rs. \u003cbr\u003e\u003cbr\u003eOwen Green and Guy Healing have shown the importance of the 3Rs in infusion technology at international meetings and in producing this book. The book will enhance uptake of the latest science behind vascular delivery systems to get better data and help influence decisions around the most appropriate model. It will also contribute to preventing repetition of method development and optimising experiments to answer specific scientific questions with the least impact on animals. \u003cbr\u003e\u003cbr\u003eAs in other areas of science, the field of infusion technology is constantly evolving. This edition of \u003ci\u003eNon-Clinical Vascular Infusion Technology \u003c\/i\u003ereviews current developments in the field that will support scientists in putting the 3Rs into practice.\"\u003cbr\u003e\u003cbr\u003e—From the Foreword by Kathryn Chapman, Head of Innovation and Translation, the National Centre for the Replacement, Refinement and Reduction of Animals in Research\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eBody Fluid Dynamics. \u003c\/strong\u003eIntroduction. Composition and units of measurement. Compartmentalization and Distribution. Movement between Compartments\/Exchange. Body Fluid Homeostasis. Summary. References. \u003cstrong\u003ePhysico-Chemical Factors\u003c\/strong\u003e\u003cb\u003e. \u003c\/b\u003eIntroduction. Osmolality. Acid-Base Balance. Viscosity. Surface Tension. Diffusion. Summary of Infusion Forces. References. \u003cstrong\u003eVascular Infusion Dynamics\u003c\/strong\u003e\u003cb\u003e. \u003c\/b\u003eEssential physiology. Intravenous Delivery Rates and Volumes. References. \u003cstrong\u003eFormulation \u003c\/strong\u003e\u003cb\u003eConsiderations. \u003c\/b\u003eIntroduction. Formulation selection strategy. Study design and species\/strain. The properties of the compound. Strategies for dealing with poor solubility. Unwanted formulation effects. Excipient toxicity. Strategies for dealing with injection site reactions and haemolysis. Strategies for dealing with poor stability. Sterility. Conclusion. References. \u003cb\u003ePrestudy analytical assessments: Equipment compatibility\u003c\/b\u003e. Stability of the formulation with the formulation storage vessel. Compatibility. Choice of material. References. Haemocompatibility\u003ci\u003e. \u003c\/i\u003eIntroduction. Objectives. Methods of assessing haemocompatibility. Discussion. Conclusion. References. \u003cb\u003eAnnex: Common excipients and vehicles.\u003c\/b\u003e\u003c\/p\u003e","brand":"Taylor \u0026 Francis Inc","offers":[{"title":"Default Title","offer_id":49408299532631,"sku":"9781439874493","price":99.75,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781439874493.jpg?v=1730502341","url":"https:\/\/bookcurl.com\/products\/nonclinical-vascular-infusion-technology-volume-i-9781439874493","provider":"Book Curl","version":"1.0","type":"link"}