{"product_id":"nmr-spectroscopy-explained-9780471730965","title":"NMR Spectroscopy Explained","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eNMR Spectroscopy Explained : Simplified Theory, Applications and Examples for Organic Chemistry and Structural Biology\u003c\/i\u003e provides a fresh, practical guide to NMR for both students and practitioners, in a clearly written and non-mathematical format. It gives the reader an intermediate level theoretical basis for understanding laboratory applications, developing concepts gradually within the context of examples and useful experiments.  \u003cul\u003e \u003cli\u003eIntroduces students to modern NMR as applied to analysis of organic compounds.\u003c\/li\u003e \u003cli\u003ePresents material in a clear, conversational style that is appealing to students.\u003c\/li\u003e \u003cli\u003eContains comprehensive coverage of how NMR experiments actually work.\u003c\/li\u003e \u003cli\u003eCombines basic ideas with practical implementation of the spectrometer.\u003c\/li\u003e \u003cli\u003eProvides an intermediate level theoretical basis for understanding laboratory experiments.\u003c\/li\u003e \u003cli\u003eDevelops concepts gradually within the context of examples and useful experiments.\u003c\/li\u003e \u003cli\u003eIntroduces the pr\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTrade Review\u003c\/b\u003e\u003cbr\u003e\"The uses of the many modern multiple NMW techniques are explained and demonstrated quite well.\" (\u003ci\u003eCHOICE\u003c\/i\u003e, September 2008)\u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003eAcknowledgments xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Fundamentalsof NMR Spectroscopy in Liquids 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction to NMR Spectroscopy 1\u003c\/p\u003e \u003cp\u003e1.2 Examples: NMR Spectroscopy of Oligosaccharides and Terpenoids 12\u003c\/p\u003e \u003cp\u003e1.3 Typical Values of Chemical Shifts and Coupling Constants 27\u003c\/p\u003e \u003cp\u003e1.4 Fundamental Concepts of NMR Spectroscopy 30\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Interpretation of Proton (1 H) NMR Spectra 39\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Assignment 39\u003c\/p\u003e \u003cp\u003e2.2 Effect of B o Field Strength on the Spectrum 40\u003c\/p\u003e \u003cp\u003e2.3 First-Order Splitting Patterns 45\u003c\/p\u003e \u003cp\u003e2.4 The Use of 1 H– 1 H Coupling Constants to Determine Stereochemistry and Conformation 52\u003c\/p\u003e \u003cp\u003e2.5 Symmetry and Chirality in NMR 54\u003c\/p\u003e \u003cp\u003e2.6 The Origin of the Chemical Shift 56\u003c\/p\u003e \u003cp\u003e2.7 J Coupling to Other NMR-Active Nuclei 61\u003c\/p\u003e \u003cp\u003e2.8 Non-First-Order Splitting Patterns: Strong Coupling 63\u003c\/p\u003e \u003cp\u003e2.9 Magnetic Equivalence 71\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 NMR Hardware and Software 74\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Sample Preparation 75\u003c\/p\u003e \u003cp\u003e3.2 Sample Insertion 77\u003c\/p\u003e \u003cp\u003e3.3 The Deuterium Lock Feedback Loop 78\u003c\/p\u003e \u003cp\u003e3.4 The Shim System 81\u003c\/p\u003e \u003cp\u003e3.5 Tuning and Matching the Probe 88\u003c\/p\u003e \u003cp\u003e3.6 NMR Data Acquisition and Acquisition Parameters 90\u003c\/p\u003e \u003cp\u003e3.7 Noise and Dynamic Range 108\u003c\/p\u003e \u003cp\u003e3.8 Special Topic: Oversampling and Digital Filtering 110\u003c\/p\u003e \u003cp\u003e3.9 NMR Data Processing—Overview 118\u003c\/p\u003e \u003cp\u003e3.10 The Fourier Transform 119\u003c\/p\u003e \u003cp\u003e3.11 Data Manipulation Before the Fourier Transform 122\u003c\/p\u003e \u003cp\u003e3.12 Data Manipulation After the Fourier Transform 126\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Carbon-13 (13 C) NMR Spectroscopy 135\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Sensitivity of 13 C 135\u003c\/p\u003e \u003cp\u003e4.2 Splitting of 13 C Signals 135\u003c\/p\u003e \u003cp\u003e4.3 Decoupling 138\u003c\/p\u003e \u003cp\u003e4.4 Heteronuclear Decoupling: 1 H Decoupled 13 C Spectra 139\u003c\/p\u003e \u003cp\u003e4.5 Decoupling Hardware 145\u003c\/p\u003e \u003cp\u003e4.6 Decoupling Software: Parameters 149\u003c\/p\u003e \u003cp\u003e4.7 The Nuclear Overhauser Effect (NOE) 150\u003c\/p\u003e \u003cp\u003e4.8 Heteronuclear Decoupler Modes 152\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 NMR Relaxation—Inversion-Recovery and the Nuclear Overhauser Effect (NOE) 155\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 The Vector Model 155\u003c\/p\u003e \u003cp\u003e5.2 One Spin in a Magnetic Field 155\u003c\/p\u003e \u003cp\u003e5.3 A Large Population of Identical Spins: Net Magnetization 157\u003c\/p\u003e \u003cp\u003e5.4 Coherence: Net Magnetization in the x–y Plane 161\u003c\/p\u003e \u003cp\u003e5.5 Relaxation 162\u003c\/p\u003e \u003cp\u003e5.6 Summary of the Vector Model 168\u003c\/p\u003e \u003cp\u003e5.7 Molecular Tumbling and NMR Relaxation 170\u003c\/p\u003e \u003cp\u003e5.8 Inversion-Recovery: Measurement of T 1 Values 176\u003c\/p\u003e \u003cp\u003e5.9 Continuous-Wave Low-Power Irradiation of One Resonance 181\u003c\/p\u003e \u003cp\u003e5.10 Homonuclear Decoupling 182\u003c\/p\u003e \u003cp\u003e5.11 Presaturation of Solvent Resonance 185\u003c\/p\u003e \u003cp\u003e5.12 The Homonuclear Nuclear Overhauser Effect (NOE) 187\u003c\/p\u003e \u003cp\u003e5.13 Summary of the Nuclear Overhauser Effect 198\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 The Spin Echo and the Attached Proton Test (APT) 200\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 The Rotating Frame of Reference 201\u003c\/p\u003e \u003cp\u003e6.2 The Radio Frequency (RF) Pulse 203\u003c\/p\u003e \u003cp\u003e6.3 The Effect of RF Pulses 206\u003c\/p\u003e \u003cp\u003e6.4 Quadrature Detection Phase Cycling and the Receiver Phase 209\u003c\/p\u003e \u003cp\u003e6.5 Chemical Shift Evolution 212\u003c\/p\u003e \u003cp\u003e6.6 Scalar (J) Coupling Evolution 213\u003c\/p\u003e \u003cp\u003e6.7 Examples of J-coupling and Chemical Shift Evolution 216\u003c\/p\u003e \u003cp\u003e6.8 The Attached Proton Test (APT) 220\u003c\/p\u003e \u003cp\u003e6.9 The Spin Echo 226\u003c\/p\u003e \u003cp\u003e6.10 The Heteronuclear Spin Echo: Controlling J-Coupling Evolution and Chemical Shift Evolution 232\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Coherence Transfer: INEPT and DEPT 238\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Net Magnetization 238\u003c\/p\u003e \u003cp\u003e7.2 Magnetization Transfer 241\u003c\/p\u003e \u003cp\u003e7.3 The Product Operator Formalism: Introduction 242\u003c\/p\u003e \u003cp\u003e7.4 Single Spin Product Operators: Chemical Shift Evolution 244\u003c\/p\u003e \u003cp\u003e7.5 Two-Spin Operators: J-coupling Evolution and Antiphase Coherence 247\u003c\/p\u003e \u003cp\u003e7.6 The Effect of RF Pulses on Product Operators 251\u003c\/p\u003e \u003cp\u003e7.7 INEPT and the Transfer of Magnetization from 1 Hto 13 C 253\u003c\/p\u003e \u003cp\u003e7.8 Selective Population Transfer (SPT) as a Way of Understanding INEPT Coherence Transfer 257\u003c\/p\u003e \u003cp\u003e7.9 Phase Cycling in INEPT 263\u003c\/p\u003e \u003cp\u003e7.10 Intermediate States in Coherence Transfer 265\u003c\/p\u003e \u003cp\u003e7.11 Zero- and Double-Quantum Operators 267\u003c\/p\u003e \u003cp\u003e7.12 Summary of Two-Spin Operators 269\u003c\/p\u003e \u003cp\u003e7.13 Refocused INEPT: Adding Spectral Editing 270\u003c\/p\u003e \u003cp\u003e7.14 DEPT: Distortionless Enhancement by Polarization Transfer 276\u003c\/p\u003e \u003cp\u003e7.15 Product Operator Analysis of the DEPT Experiment 283\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Shaped Pulses Pulsed Field Gradients and Spin Locks: Selective 1D NOE and 1D TOCSY 289\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introducing Three New Pulse Sequence Tools 289\u003c\/p\u003e \u003cp\u003e8.2 The Effect of Off-Resonance Pulses on Net Magnetization 291\u003c\/p\u003e \u003cp\u003e8.3 The Excitation Profile for Rectangular Pulses 297\u003c\/p\u003e \u003cp\u003e8.4 Selective Pulses and Shaped Pulses 299\u003c\/p\u003e \u003cp\u003e8.5 Pulsed Field Gradients 301\u003c\/p\u003e \u003cp\u003e8.6 Combining Shaped Pulses and Pulsed Field Gradients: “Excitation Sculpting” 308\u003c\/p\u003e \u003cp\u003e8.7 Coherence Order: Using Gradients to Select a Coherence Pathway 316\u003c\/p\u003e \u003cp\u003e8.8 Practical Aspects of Pulsed Field Gradients and Shaped Pulses 319\u003c\/p\u003e \u003cp\u003e8.9 1D Transient NOE using DPFGSE 321\u003c\/p\u003e \u003cp\u003e8.10 The Spin Lock 333\u003c\/p\u003e \u003cp\u003e8.11 Selective 1D ROESY and 1D TOCSY 338\u003c\/p\u003e \u003cp\u003e8.12 Selective 1D TOCSY using DPFGSE 343\u003c\/p\u003e \u003cp\u003e8.13 RF Power Levels for Shaped Pulses and Spin Locks 348\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Two-Dimensional NMR Spectroscopy: HETCOR COSY and TOCSY 353\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction to Two-Dimensional NMR 353\u003c\/p\u003e \u003cp\u003e9.2 HETCOR: A 2D Experiment Created from the 1D INEPT Experiment 354\u003c\/p\u003e \u003cp\u003e9.3 A General Overview of 2D NMR Experiments 364\u003c\/p\u003e \u003cp\u003e9.4 2D Correlation Spectroscopy (COSY) 370\u003c\/p\u003e \u003cp\u003e9.5 Understanding COSY with Product Operators 386\u003c\/p\u003e \u003cp\u003e9.6 2D TOCSY (Total Correlation Spectroscopy) 393\u003c\/p\u003e \u003cp\u003e9.7 Data Sampling in t 1 and the 2D Spectral Window 398\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Advanced NMR Theory: NOESY and DQF-COSY 408\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Spin Kinetics: Derivation of the Rate Equation for Cross-Relaxation 409\u003c\/p\u003e \u003cp\u003e10.2 Dynamic Processes and Chemical Exchange in NMR 414\u003c\/p\u003e \u003cp\u003e10.3 2D NOESY and 2D ROESY 425\u003c\/p\u003e \u003cp\u003e10.4 Expanding Our View of Coherence: Quantum Mechanics and Spherical Operators 439\u003c\/p\u003e \u003cp\u003e10.5 Double-Quantum Filtered COSY (DQF-COSY) 447\u003c\/p\u003e \u003cp\u003e10.6 Coherence Pathway Selection in NMR Experiments 450\u003c\/p\u003e \u003cp\u003e10.7 The Density Matrix Representation of Spin States 469\u003c\/p\u003e \u003cp\u003e10.8 The Hamiltonian Matrix: Strong Coupling and Ideal Isotropic (TOCSY) Mixing 478\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Inverse Heteronuclear 2D Experiments: HSQC HMQC and HMBC 489\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Inverse Experiments: 1 H Observe with 13 C Decoupling 490\u003c\/p\u003e \u003cp\u003e11.2 General Appearance of Inverse 2D Spectra 498\u003c\/p\u003e \u003cp\u003e11.3 Examples of One-Bond Inverse Correlation (HMQC and HSQC) Without 13 C Decoupling 501\u003c\/p\u003e \u003cp\u003e11.4 Examples of Edited 13 C-Decoupled HSQC Spectra 504\u003c\/p\u003e \u003cp\u003e11.5 Examples of HMBC Spectra 509\u003c\/p\u003e \u003cp\u003e11.6 Structure Determination Using HSQC and HMBC 517\u003c\/p\u003e \u003cp\u003e11.7 Understanding the HSQC Pulse Sequence 522\u003c\/p\u003e \u003cp\u003e11.8 Understanding the HMQC Pulse Sequence 533\u003c\/p\u003e \u003cp\u003e11.9 Understanding the Heteronuclear Multiple-Bond Correlation (HMBC) Pulse Sequence 535\u003c\/p\u003e \u003cp\u003e11.10 Structure Determination by NMR—An Example 538\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Biological NMR Spectroscopy 551\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Applications of NMR in Biology 551\u003c\/p\u003e \u003cp\u003e12.2 Size Limitations in Solution-State NMR 553\u003c\/p\u003e \u003cp\u003e12.3 Hardware Requirements for Biological NMR 558\u003c\/p\u003e \u003cp\u003e12.4 Sample Preparation and Water Suppression 564\u003c\/p\u003e \u003cp\u003e12.5 1 H Chemical Shifts of Peptides and Proteins 570\u003c\/p\u003e \u003cp\u003e12.6 NOE Interactions Between One Residue and the Next Residue in the Sequence 577\u003c\/p\u003e \u003cp\u003e12.7 Sequence-Specific Assignment Using Homonuclear 2D Spectra 580\u003c\/p\u003e \u003cp\u003e12.8 Medium and Long-Range NOE Correlations 586\u003c\/p\u003e \u003cp\u003e12.9 Calculation of 3D Structure Using NMR Restraints 590\u003c\/p\u003e \u003cp\u003e12.10 15 N-Labeling and 3D NMR 596\u003c\/p\u003e \u003cp\u003e12.11 Three-Dimensional NMR Pulse Sequences: 3D HSQC–TOCSY and 3D TOCSY–HSQC 601\u003c\/p\u003e \u003cp\u003e12.12 Triple-Resonance NMR on Doubly-Labeled (15 N 13 C) Proteins 610\u003c\/p\u003e \u003cp\u003e12.13 New Techniques for Protein NMR: Residual Dipolar Couplings and Transverse Relaxation Optimized Spectroscopy (TROSY) 621\u003c\/p\u003e \u003cp\u003eAppendix A: A Pictorial Key to NMR Spin States 627\u003c\/p\u003e \u003cp\u003eAppendix B: A Survey of Two-Dimensional NMR Experiments 634\u003c\/p\u003e \u003cp\u003eIndex 643\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":51037070819671,"sku":"9780471730965","price":140.35,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9780471730965.jpg?v=1750934254","url":"https:\/\/bookcurl.com\/products\/nmr-spectroscopy-explained-9780471730965","provider":"Book Curl","version":"1.0","type":"link"}