{"product_id":"nmr-data-interpretation-explained-9781118370223","title":"NMR Data Interpretation Explained","description":"\u003cb\u003eBook Synopsis\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eThrough numerous examples, the principles of the relationship between chemical structure and the NMR spectrum are developed in a logical, step-by-step fashion\u003c\/p\u003e \u003cul\u003e \u003cli\u003eIncludes examples and exercises based on real NMR data including full 600 MHz one- and two-dimensional datasets of sugars, peptides, steroids and natural products\u003c\/li\u003e \u003cli\u003eIncludes detailed solutions and explanations in the text for the numerous examples and problems and also provides large, very detailed and annotated sets of NMR data for use in understanding the material\u003c\/li\u003e \u003cli\u003eDescribes both simple aspects of solution-state NMR of small molecules as well as more complex topics not usually covered in NMR books such ascomplex splitting patterns, weak long-range couplings, spreadsheet analysis of strong coupling patterns and resonance structure analysis for prediction of chemical shifts\u003c\/li\u003e \u003cli\u003eAdvanced topics include all of the common two-dimensional experiments (COSY, ROESY, NOESY, TOCSY, HSQC, HMBC) covered \u003cbr\u003e\u003cbr\u003e\u003cb\u003eTable of Contents\u003c\/b\u003e\u003cbr\u003e\u003cp\u003eExamples xi\u003c\/p\u003e \u003cp\u003ePreface xiii\u003c\/p\u003e \u003cp\u003eAcknowledgments xv\u003c\/p\u003e \u003cp\u003eAbout the Companion Website xvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 1 Spectroscopy and the Proton NMR Experiment 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 What is the Structure of a Molecule? 1\u003c\/p\u003e \u003cp\u003e2 Mass Spectrometry 3\u003c\/p\u003e \u003cp\u003e2.1 Ionization Methods and Molecular Ions 4\u003c\/p\u003e \u003cp\u003e2.1.1 Electron Impact (EI) 4\u003c\/p\u003e \u003cp\u003e2.1.2 Soft Ionization 5\u003c\/p\u003e \u003cp\u003e2.2 High-Resolution Mass Spectrometry and Exact Mass 5\u003c\/p\u003e \u003cp\u003e2.3 Isotope Patterns and the Halogens Br and Cl 7\u003c\/p\u003e \u003cp\u003e3 Infrared (IR) Spectroscopy 9\u003c\/p\u003e \u003cp\u003e4 Ultraviolet (UV) and Visible Spectroscopy 10\u003c\/p\u003e \u003cp\u003e5 A Highly Simplified View of the NMR Experiment 13\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 2 Chemical Shifts and Splitting Patterns 17\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Chemical Shifts in the Proton Spectrum 17\u003c\/p\u003e \u003cp\u003e2 Splitting: The Effect of One Neighbor: A Doublet 21\u003c\/p\u003e \u003cp\u003e3 Splitting: The Effect of Two Neighbors: A Triplet 23\u003c\/p\u003e \u003cp\u003e4 Splitting: The Effect of Three Neighbors: A Quartet 25\u003c\/p\u003e \u003cp\u003e5 Splitting: The Effect of “n” Neighbors: A Multiplet 30\u003c\/p\u003e \u003cp\u003e6 Using Splitting Patterns to Choose from a Group of Isomers 34\u003c\/p\u003e \u003cp\u003e7 Peak Intensities (Peak Areas) and the Number of Protons in a Peak 37\u003c\/p\u003e \u003cp\u003e8 Publication Format for Proton NMR Data 39\u003c\/p\u003e \u003cp\u003e9 Recognizing Common Structure Fragments 41\u003c\/p\u003e \u003cp\u003e10 Overlap in Proton NMR Spectra. Example: 1-Methoxyhexane 45\u003c\/p\u003e \u003cp\u003e11 Protons Bound to Oxygen: OH Groups. Example: 2-Ethyl-1-Butanol 48\u003c\/p\u003e \u003cp\u003e12 Summary of Chemical Shifts and Splitting Patterns 50\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 3 Proton ( \u003csup\u003e1\u003c\/sup\u003eH) NMR of Aromatic Compounds 51\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Benzene: The Aromatic Ring Current and the Shielding Cone 51\u003c\/p\u003e \u003cp\u003e2 Monsubstituted Benzene: X-C\u003csub\u003e6\u003c\/sub\u003eH\u003csub\u003e5\u003c\/sub\u003e 52\u003c\/p\u003e \u003cp\u003e2.1 Toluene 52\u003c\/p\u003e \u003cp\u003e2.2 Aromatic Chemical Shifts: Resonance Structures 54\u003c\/p\u003e \u003cp\u003e2.3 Nitrobenzene 55\u003c\/p\u003e \u003cp\u003e2.4 Anisole 56\u003c\/p\u003e \u003cp\u003e2.5 Substituent Effects on Aromatic Chemical Shifts 58\u003c\/p\u003e \u003cp\u003e2.6 Long-Range \u003ci\u003eJ \u003c\/i\u003eCouplings in Aromatic Rings: Protons 4 Bonds Apart 59\u003c\/p\u003e \u003cp\u003e3 Disubstituted Benzene: X-C\u003csub\u003e6\u003c\/sub\u003eH\u003csub\u003e4\u003c\/sub\u003e-Y 62\u003c\/p\u003e \u003cp\u003e3.1 Symmetrical Disubstituted Benzene: X-C\u003csub\u003e6\u003c\/sub\u003eH\u003csub\u003e4\u003c\/sub\u003e-X 62\u003c\/p\u003e \u003cp\u003e3.2 Unsymmetrical Disubstituted Benzene, X-C\u003csub\u003e6\u003c\/sub\u003eH\u003csub\u003e4\u003c\/sub\u003e-Y 72\u003c\/p\u003e \u003cp\u003e3.2.1 \u003ci\u003epara \u003c\/i\u003e(1,4) Disubstituted Benzene: \u003ci\u003ep\u003c\/i\u003e-X-C\u003csub\u003e6\u003c\/sub\u003eH\u003csub\u003e4\u003c\/sub\u003e-Y 73\u003c\/p\u003e \u003cp\u003e3.2.2 \u003ci\u003emeta \u003c\/i\u003e(1,3) Disubstituted Benzene: \u003ci\u003em\u003c\/i\u003e-X-C\u003csub\u003e6\u003c\/sub\u003eH\u003csub\u003e4\u003c\/sub\u003e-Y 78\u003c\/p\u003e \u003cp\u003e3.2.3 \u003ci\u003eortho \u003c\/i\u003e(1,2) Disubstituted Benzene: \u003ci\u003eo\u003c\/i\u003e-X-C\u003csub\u003e6\u003c\/sub\u003eH\u003csub\u003e4\u003c\/sub\u003e-Y 87\u003c\/p\u003e \u003cp\u003e4 Coupling Between Aromatic Ring Protons and Substitutent Protons; Homonuclear Decoupling 100\u003c\/p\u003e \u003cp\u003e4.1 The Methyl Group (CH\u003csub\u003e3\u003c\/sub\u003e) 100\u003c\/p\u003e \u003cp\u003e4.2 The Methoxy Substituent (OCH\u003csub\u003e3\u003c\/sub\u003e) 102\u003c\/p\u003e \u003cp\u003e4.3 The Formyl (H-C=O) Substituent 103\u003c\/p\u003e \u003cp\u003e5 Trisubstituted Aromatic Rings: The AB\u003csub\u003e2\u003c\/sub\u003e System 106\u003c\/p\u003e \u003cp\u003e6 Other Aromatic Ring Systems: Heteroaromatics, Five-Membered Rings and Fused Rings 110\u003c\/p\u003e \u003cp\u003e6.1 Pyridine (C\u003csub\u003e5\u003c\/sub\u003eH\u003csub\u003e5\u003c\/sub\u003eN) 111\u003c\/p\u003e \u003cp\u003e6.2 Pyrrole (C\u003csub\u003e4\u003c\/sub\u003eH\u003csub\u003e5\u003c\/sub\u003eN) 112\u003c\/p\u003e \u003cp\u003e6.3 Furan (C\u003csub\u003e4\u003c\/sub\u003eH\u003csub\u003e4\u003c\/sub\u003eO) 113\u003c\/p\u003e \u003cp\u003e6.4 Naphthalene (C\u003csub\u003e10\u003c\/sub\u003eH\u003csub\u003e8\u003c\/sub\u003e) 115\u003c\/p\u003e \u003cp\u003e6.5 Indole (C\u003csub\u003e8\u003c\/sub\u003eH\u003csub\u003e7\u003c\/sub\u003eN) 117\u003c\/p\u003e \u003cp\u003e6.6 Quinoline and Isoquinoline (C\u003csub\u003e9\u003c\/sub\u003eH\u003csub\u003e7\u003c\/sub\u003eN) 118\u003c\/p\u003e \u003cp\u003e7 Summary of New Concepts: Proton NMR of Aromatic Compounds 120\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 4 Carbon-13 (\u003csup\u003e13\u003c\/sup\u003eC) NMR 125\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Natural Abundance and Sensitivity of \u003csup\u003e13\u003c\/sup\u003eC 125\u003c\/p\u003e \u003cp\u003e2 Proton Decoupling—Removing the Splitting Effect of Nearby Protons 126\u003c\/p\u003e \u003cp\u003e3 Intensity of \u003csup\u003e13\u003c\/sup\u003eC Peaks—Symmetry and Relaxation 126\u003c\/p\u003e \u003cp\u003e4 Chemical Shifts of Carbon-13 (\u003csup\u003e13\u003c\/sup\u003eC) Nuclei 129\u003c\/p\u003e \u003cp\u003e4.1 \u003csup\u003e13\u003c\/sup\u003eC Frequency and Chemical Shift Reference 129\u003c\/p\u003e \u003cp\u003e4.2 General Regions of the \u003csup\u003e13\u003c\/sup\u003eC Chemical Shift Scale 130\u003c\/p\u003e \u003cp\u003e4.3 Correlations between \u003csup\u003e1\u003c\/sup\u003eH and \u003csup\u003e13\u003c\/sup\u003eC Chemical Shift for a C-H Pair 132\u003c\/p\u003e \u003cp\u003e4.4 Quantitation of the Steric Effect for \u003csup\u003e13\u003c\/sup\u003eC Chemical Shifts 135\u003c\/p\u003e \u003cp\u003e4.5 Example of Steric Effects on \u003csup\u003e13\u003c\/sup\u003eC Chemical Shifts: The “Crowded CH” in Steroids 141\u003c\/p\u003e \u003cp\u003e4.6 The \u003ci\u003eγ-gauche \u003c\/i\u003eEffect: Steric Shifts That Give Stereochemical Information 143\u003c\/p\u003e \u003cp\u003e4.7 Inductive Effects in \u003csup\u003e13\u003c\/sup\u003eC Chemical Shifts: Electronegative Atoms 147\u003c\/p\u003e \u003cp\u003e4.8 The Effect of Ring Strain on \u003csup\u003e13\u003c\/sup\u003eC Chemical Shift of sp\u003csup\u003e3\u003c\/sup\u003e-Hybridized Carbons 150\u003c\/p\u003e \u003cp\u003e5 Quaternary Carbons: the Carbonyl Group 151\u003c\/p\u003e \u003cp\u003e6 Simple Aromatic Compounds: Substituent Effects on \u003csup\u003e13\u003c\/sup\u003eC Chemical Shifts 156\u003c\/p\u003e \u003cp\u003e7 Highly Oxygenated Benzene Rings and Coumarin 161\u003c\/p\u003e \u003cp\u003e8 Fused Rings and Heteroaromatic Compounds 165\u003c\/p\u003e \u003cp\u003e8.1 Pyridine (C\u003csub\u003e5\u003c\/sub\u003eH\u003csub\u003e5\u003c\/sub\u003eN) 165\u003c\/p\u003e \u003cp\u003e8.2 Pyrrole (C\u003csub\u003e4\u003c\/sub\u003eH\u003csub\u003e5\u003c\/sub\u003eN) 167\u003c\/p\u003e \u003cp\u003e8.3 Furan (C\u003csub\u003e4\u003c\/sub\u003eH\u003csub\u003e4\u003c\/sub\u003eO) 168\u003c\/p\u003e \u003cp\u003e8.4 Naphthalene (C\u003csub\u003e10\u003c\/sub\u003eH\u003csub\u003e8\u003c\/sub\u003e) 168\u003c\/p\u003e \u003cp\u003e8.5 Indole (C\u003csub\u003e8\u003c\/sub\u003eH\u003csub\u003e7\u003c\/sub\u003eN) 170\u003c\/p\u003e \u003cp\u003e8.6 Quinoline and Isoquinoline (C\u003csub\u003e9\u003c\/sub\u003eH\u003csub\u003e7\u003c\/sub\u003eN) 173\u003c\/p\u003e \u003cp\u003e9 Edited \u003csup\u003e13\u003c\/sup\u003eC Spectra: DEPT 174\u003c\/p\u003e \u003cp\u003e9.1 Non-decoupled \u003csup\u003e13\u003c\/sup\u003eC Spectra 175\u003c\/p\u003e \u003cp\u003e9.2 Edited \u003csup\u003e13\u003c\/sup\u003eC Spectra 176\u003c\/p\u003e \u003cp\u003e9.3 Practical Details of the DEPT Experiment 181\u003c\/p\u003e \u003cp\u003e9.3.1 Sensitivity 181\u003c\/p\u003e \u003cp\u003e9.3.2 Pulse Calibration 181\u003c\/p\u003e \u003cp\u003e9.3.3 \u003ci\u003eJ \u003c\/i\u003eValue Setting 182\u003c\/p\u003e \u003cp\u003e9.3.4 Phase Correction 185\u003c\/p\u003e \u003cp\u003e10 The Effect of Other Magnetic Nuclei on the \u003csup\u003e13\u003c\/sup\u003eC Spectrum: \u003csup\u003e31\u003c\/sup\u003eP, \u003csup\u003e19\u003c\/sup\u003eF, \u003csup\u003e2\u003c\/sup\u003eH and \u003csup\u003e14\u003c\/sup\u003eN 185\u003c\/p\u003e \u003cp\u003e10.1 Splitting of \u003csup\u003e13\u003c\/sup\u003eC Peaks by Deuterium (\u003csup\u003e2\u003c\/sup\u003eH) 185\u003c\/p\u003e \u003cp\u003e10.2 Splitting of \u003csup\u003e13\u003c\/sup\u003eC Peaks by Phosphorus (\u003csup\u003e31\u003c\/sup\u003eP) 186\u003c\/p\u003e \u003cp\u003e10.3 Splitting of \u003csup\u003e13\u003c\/sup\u003eC Peaks by Fluorine (\u003csup\u003e19\u003c\/sup\u003eF) 188\u003c\/p\u003e \u003cp\u003e10.4 Splitting and Broadening of \u003csup\u003e13\u003c\/sup\u003eC Peaks by Nitrogen (\u003csup\u003e14\u003c\/sup\u003eN) 189\u003c\/p\u003e \u003cp\u003e11 Direct Observation of Nuclei Other Than Proton (\u003csup\u003e1\u003c\/sup\u003eH) and Carbon (\u003csup\u003e13\u003c\/sup\u003eC) 190\u003c\/p\u003e \u003cp\u003e11.1 Phosphorus-31 (\u003csup\u003e31\u003c\/sup\u003eP) NMR 192\u003c\/p\u003e \u003cp\u003e11.2 Fluorine-19 (\u003csup\u003e19\u003c\/sup\u003eF) NMR 194\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 5 Alkenes (Olefins) 198\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Proton Chemical Shifts of Simple Olefins 199\u003c\/p\u003e \u003cp\u003e2 Short-Range (Two and Three Bond) Coupling Constants ( \u003ci\u003eJ \u003c\/i\u003eValues) in Olefins 202\u003c\/p\u003e \u003cp\u003e3 The Allylic Coupling: A Long-Range (Four-Bond) \u003ci\u003eJ \u003c\/i\u003eCoupling 205\u003c\/p\u003e \u003cp\u003e4 Long-Range Olefin Couplings in Cholesterol: The \u003ci\u003ebis\u003c\/i\u003e-Allylic Coupling (\u003csup\u003e5\u003c\/sup\u003eJ) 209\u003c\/p\u003e \u003cp\u003e5 Carbon-13 Chemical Shifts of Hydrocarbon Olefins (Alkenes) 210\u003c\/p\u003e \u003cp\u003e6 Resonance Effects on Olefinic \u003csup\u003e13\u003c\/sup\u003eC Chemical Shifts 214\u003c\/p\u003e \u003cp\u003e7 Alkynes 225\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 6 Chirality and Stereochemistry: Natural Products 227\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 The Molecules of Nature 227\u003c\/p\u003e \u003cp\u003e2 Chirality, Chiral Centers, Chiral Molecules, and the Chiral Environment 230\u003c\/p\u003e \u003cp\u003e3 The AB System 232\u003c\/p\u003e \u003cp\u003e4 Detailed Analysis of the AB Spectrum: Calculating the Chemical Shifts 234\u003c\/p\u003e \u003cp\u003e5 The ABX System 237\u003c\/p\u003e \u003cp\u003e6 Variations on the ABX Theme: ABX\u003csub\u003e3\u003c\/sub\u003e, ABX\u003csub\u003e2\u003c\/sub\u003e and ABXY 245\u003c\/p\u003e \u003cp\u003e7 The Effect of Chirality on \u003csup\u003e13\u003c\/sup\u003eC Spectra. Diastereotopic Carbons 249\u003c\/p\u003e \u003cp\u003e8 A Closer Look at Chemical Shift Equivalence in an Asymmetric Environment 251\u003c\/p\u003e \u003cp\u003e8.1 Chemical Shift Equivalence of CH\u003csub\u003e3\u003c\/sub\u003e Group Protons 251\u003c\/p\u003e \u003cp\u003e8.2 Non-Equivalence of CH\u003csub\u003e2\u003c\/sub\u003e Group Protons 252\u003c\/p\u003e \u003cp\u003e8.3 Chemical Shift Equivalence by Symmetry 252\u003c\/p\u003e \u003cp\u003e9 J Couplings and Chemical Shifts in the Rigid Cyclohexane Chair System 255\u003c\/p\u003e \u003cp\u003e9.1 Cyclohexene and Cyclohexenone 262\u003c\/p\u003e \u003cp\u003e10 A Detailed Look at the Dependence of \u003csup\u003e3\u003c\/sup\u003e\u003ci\u003ej\u003c\/i\u003e\u003csub\u003eHH\u003c\/sub\u003e on Dihedral Angle: The Karplus Relation 266\u003c\/p\u003e \u003cp\u003e11 Magnetic Non-Equivalence. The X-CH\u003csub\u003e2\u003c\/sub\u003e-CH\u003csub\u003e2\u003c\/sub\u003e-Y Spin System: A\u003csub\u003e2\u003c\/sub\u003eB\u003csub\u003e2\u003c\/sub\u003e and AA’BB’ Patterns 276\u003c\/p\u003e \u003cp\u003e12 Bicyclic Compounds and Small Rings (Three- and Four-Membered) 286\u003c\/p\u003e \u003cp\u003e12.1 The Bicyclo[2.2.1] Ring System 286\u003c\/p\u003e \u003cp\u003e12.2 The Bicyclo[3.1.0] Ring System 291\u003c\/p\u003e \u003cp\u003e12.3 The Bicyclo[3.1.1] Ring System 294\u003c\/p\u003e \u003cp\u003eReference 298\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 7 Selective Proton Experiments: Biological Molecules 299\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Sugars: Monosaccharides and Oligosaccharides 299\u003c\/p\u003e \u003cp\u003e2 Slowing of OH Exchange in Polar Aprotic Solvents Like DMSO 305\u003c\/p\u003e \u003cp\u003e3 Selective TOCSY Applied to the Assignment of the \u003csup\u003e1\u003c\/sup\u003eH Spectra of Sugars 307\u003c\/p\u003e \u003cp\u003e4 The Selective NOE (Nuclear Overhauser Effect) Experiment 319\u003c\/p\u003e \u003cp\u003e4.1 Recognizing Artifacts in Selective NOE Spectra 320\u003c\/p\u003e \u003cp\u003e4.2 The Relationship Between NOE Intensity and Distance 320\u003c\/p\u003e \u003cp\u003e4.3 Magnetization Transfer in the Selective TOCSY and Selective NOE Experiments 321\u003c\/p\u003e \u003cp\u003e5 Amino Acids and Peptides 331\u003c\/p\u003e \u003cp\u003e6 Nucleic Acids 348\u003c\/p\u003e \u003cp\u003e7 Parameter Settings for NMR Experiment Setup and NMR Data Processing 357\u003c\/p\u003e \u003cp\u003eBibliography 358\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 8 Homonuclear Two-Dimensional NMR: Correlation of One Hydrogen (\u003csup\u003e1\u003c\/sup\u003eH) to Another 359\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Selective TOCSY Experiments Displayed as a Stacked Plot 359\u003c\/p\u003e \u003cp\u003e2 The Two-Dimensional COSY Experiment 365\u003c\/p\u003e \u003cp\u003e3 Shape and Fine Structure of COSY Crosspeaks; Contour Plots 370\u003c\/p\u003e \u003cp\u003e4 2D-COSY Spectra of Sugars 376\u003c\/p\u003e \u003cp\u003e5 2D-COSY Spectra of Aromatic Compounds 391\u003c\/p\u003e \u003cp\u003e6 Parameter Settings in the 2D COSY Experiment; The DQF-COSY Experiment 397\u003c\/p\u003e \u003cp\u003e7 COSY Spectra of Peptides 399\u003c\/p\u003e \u003cp\u003e8 COSY Spectra of Natural Products 405\u003c\/p\u003e \u003cp\u003e9 Two-Dimensional (2D) TOCSY (Total Correlation Spectroscopy) 412\u003c\/p\u003e \u003cp\u003e10 Two-Dimensional (2D) NOESY (Nuclear Overhauser Effect Spectroscopy) 423\u003c\/p\u003e \u003cp\u003eParameter Settings Used for 2D Spectra in this Chapter 429\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 9 Heteronuclear Two-Dimensional NMR: Correlation of One Hydrogen (\u003csup\u003e1\u003c\/sup\u003eH) to One Carbon (\u003csup\u003e13\u003c\/sup\u003eC) 430\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 3-Heptanone: A Thought Experiment 430\u003c\/p\u003e \u003cp\u003e2 Edited HSQC: Making the CH\u003csub\u003e2\u003c\/sub\u003e Protons Stand Out 436\u003c\/p\u003e \u003cp\u003e3 The 2D-HSQC Spectrum of Cholesterol 443\u003c\/p\u003e \u003cp\u003e4 A Detailed Look at the HSQC Experiment 455\u003c\/p\u003e \u003cp\u003e5 Parameters and Settings for the 2D-HSQC Experiment 458\u003c\/p\u003e \u003cp\u003e5.1 Spectral Window 458\u003c\/p\u003e \u003cp\u003e5.2 Acquisition Time 458\u003c\/p\u003e \u003cp\u003e5.3 One-Bond \u003ci\u003eJ \u003c\/i\u003eCoupling Value 459\u003c\/p\u003e \u003cp\u003e5.4 Number of 1D Spectra Acquired: \u003ci\u003eF\u003c\/i\u003e\u003csub\u003e1\u003c\/sub\u003e Resolution 460\u003c\/p\u003e \u003cp\u003e5.5 Number of Scans: Sensitivity 460\u003c\/p\u003e \u003cp\u003e6 Data Processing: Phase Correction in Two Dimensions 460\u003c\/p\u003e \u003cp\u003e7 Long-Range Couplings between \u003csup\u003e1\u003c\/sup\u003eH and \u003csup\u003e13\u003c\/sup\u003eC 463\u003c\/p\u003e \u003cp\u003e8 2D-HMBC (Heteronuclear Multiple-Bond Correlation) 465\u003c\/p\u003e \u003cp\u003e8.1 2D-HMBC Spectra of Aromatic Compounds 467\u003c\/p\u003e \u003cp\u003e8.2 HMBC Spectra of Natural Products: Using the Methyl Correlations 475\u003c\/p\u003e \u003cp\u003e8.3 HMBC Spectra of Sugars 491\u003c\/p\u003e \u003cp\u003e9 Parameters and Settings for the 2D-HMBC Experiment 495\u003c\/p\u003e \u003cp\u003e9.1 Spectral Window 495\u003c\/p\u003e \u003cp\u003e9.2 Acquisition Time 496\u003c\/p\u003e \u003cp\u003e9.3 One-Bond and Long-Range \u003ci\u003eJCH \u003c\/i\u003eCoupling Values 496\u003c\/p\u003e \u003cp\u003e9.4 Number of Scans 496\u003c\/p\u003e \u003cp\u003e10 Comparison of HSQC and HMBC 496\u003c\/p\u003e \u003cp\u003e11 HMBC Variants 497\u003c\/p\u003e \u003cp\u003eParameter Settings Used for 2D Spectra in this Chapter 497\u003c\/p\u003e \u003cp\u003eReferences 498\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 10 Structure Elucidation Using 2D NMR 499\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Literature Structure Problems 500\u003c\/p\u003e \u003cp\u003e2 Sesquiterpenoids 501\u003c\/p\u003e \u003cp\u003e3 Steroids 522\u003c\/p\u003e \u003cp\u003e4 Oligosaccharides 552\u003c\/p\u003e \u003cp\u003e5 Alkaloids 574\u003c\/p\u003e \u003cp\u003e6 Triterpenes 597\u003c\/p\u003e \u003cp\u003eReference 615\u003c\/p\u003e \u003cp\u003eIndex 617\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":49406860755287,"sku":"9781118370223","price":114.26,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/1739\/5799\/files\/9781118370223.jpg?v=1730497365","url":"https:\/\/bookcurl.com\/products\/nmr-data-interpretation-explained-9781118370223","provider":"Book Curl","version":"1.0","type":"link"}